Antibioticoterapia de corta duración versus ciclo prolongado para la neumonía adquirida en el hospital en adultos graves
Información
- DOI:
- https://doi.org/10.1002/14651858.CD007577.pub2Copiar DOI
- Base de datos:
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- Cochrane Database of Systematic Reviews
- Versión publicada:
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- 05 octubre 2011see what's new
- Tipo:
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- Intervention
- Etapa:
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- Review
- Grupo Editorial Cochrane:
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Grupo Cochrane de Infecciones respiratorias agudas
- Copyright:
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- Copyright © 2012 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Cifras del artículo
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Autores
Contributions of authors
Ged Dempsey (GD) conceived the idea for the systematic review.
Richard Pugh (RP), Chris Grant (CG), Richard Cooke (RC) and GD contributed to the drafting of the protocol and final review.
RP and CG were responsible for study selection, quality assessment and data extraction.
GD assisted in resolution of any disagreement over study selection and quality assessment.
RC and GD provided content expertise.
Sources of support
Internal sources
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No sources of support supplied
External sources
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Cochrane Acute Respiratory Infections Group, Australia.
Development and conduct of literature search, and editorial support.
Declarations of interest
None.
Acknowledgements
We would like to thank Julio Medina, Julio Pontet and Daiana Stolz for making available additional study data, and to thank the following authors for their assistance: Marcel Hochreiter, Stefan Schröder, Vandack Nobre and Jerome Pugin. We are very grateful to the Cochrane Acute Respiratory Infections Group editorial staff for their help with the conduct of the review, in particular to Elizabeth Dooley, and to Sarah Thorning for her assistance with design and conduct of our searches. We also wish to thank the follow for commenting on the draft review: SM Shariful Islam, Despoina Koulenti, Jonathan Li, Guy W. Soo Hoo, Nelcy Rodriguez and Allen Cheng.
Version history
| Published | Title | Stage | Authors | Version |
| 2015 Aug 24 | Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults | Review | Richard Pugh, Chris Grant, Richard PD Cooke, Ged Dempsey | |
| 2011 Oct 05 | Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults | Review | Richard Pugh, Chris Grant, Richard PD Cooke, Ged Dempsey | |
| 2009 Jan 21 | Short course versus prolonged course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults | Protocol | Richard Pugh, Chris Grant, Richard PD Cooke, Ged Dempsey | |
Differences between protocol and review
Between publication of the review protocol in January 2009 and writing the review, it had become evident that promising approaches to reducing unnecessary antibiotic administration in HAP other than comparing two fixed durations of therapy were being investigated, including procalcitonin‐guided therapy. For this reason we broadened the inclusion criteria from "RCTs comparing fixed durations of antibiotic therapy..." to also include: "or comparing a protocol intended to reduce duration of antibiotic therapy with standard care." Since this would involve studies with variable durations of therapy, it was felt important to include "Duration of antibiotic therapy" as a further outcome measure.
Our original intention was to exclude trials enrolling patients with haematological malignancy, chemically‐induced immune‐suppression or HIV/AIDS; this was subsequently revised to: "We intended to exclude data from patients with haematological malignancy, chemically‐induced immune‐suppression or HIV/AIDS where possible."
Lastly, anticipating potential variation in outcome reporting, other modifications to outcome measures included: separation of non‐resolution and recurrence outcomes and the addition of ICU mortality and duration of mechanical ventilation.
