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Cochrane Database of Systematic Reviews

Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults

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Información

DOI:
https://doi.org/10.1002/14651858.CD007577.pub2Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 05 octubre 2011see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:
  1. Grupo Cochrane de Infecciones respiratorias agudas

Copyright:
  1. Copyright © 2012 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Autores

  • Richard Pugh

    Correspondencia a: Department of Anaesthetics, Glan Clwyd Hospital, Rhyl, UK

    [email protected]

  • Chris Grant

    Department of Critical Care, University Hospital Aintree, Liverpool, UK

  • Richard PD Cooke

    Department of Microbiology, University Hospital Aintree, Liverpool, UK

  • Ged Dempsey

    Department of Critical Care, University Hospital Aintree, Liverpool, UK

Contributions of authors

Ged Dempsey (GD) conceived the idea for the systematic review.
Richard Pugh (RP), Chris Grant (CG), Richard Cooke (RC) and GD contributed to the drafting of the protocol and final review.
RP and CG were responsible for study selection, quality assessment and data extraction.
GD assisted in resolution of any disagreement over study selection and quality assessment.
RC and GD provided content expertise.

Sources of support

Internal sources

  • No sources of support supplied

External sources

  • Cochrane Acute Respiratory Infections Group, Australia.

    Development and conduct of literature search, and editorial support.

Declarations of interest

None.

Acknowledgements

We would like to thank Julio Medina, Julio Pontet and Daiana Stolz for making available additional study data, and to thank the following authors for their assistance: Marcel Hochreiter, Stefan Schröder, Vandack Nobre and Jerome Pugin. We are very grateful to the Cochrane Acute Respiratory Infections Group editorial staff for their help with the conduct of the review, in particular to Elizabeth Dooley, and to Sarah Thorning for her assistance with design and conduct of our searches. We also wish to thank the follow for commenting on the draft review: SM Shariful Islam, Despoina Koulenti, Jonathan Li, Guy W. Soo Hoo, Nelcy Rodriguez and Allen Cheng.

Version history

Published

Title

Stage

Authors

Version

2015 Aug 24

Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults

Review

Richard Pugh, Chris Grant, Richard PD Cooke, Ged Dempsey

https://doi.org/10.1002/14651858.CD007577.pub3

2011 Oct 05

Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults

Review

Richard Pugh, Chris Grant, Richard PD Cooke, Ged Dempsey

https://doi.org/10.1002/14651858.CD007577.pub2

2009 Jan 21

Short course versus prolonged course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults

Protocol

Richard Pugh, Chris Grant, Richard PD Cooke, Ged Dempsey

https://doi.org/10.1002/14651858.CD007577

Differences between protocol and review

Between publication of the review protocol in January 2009 and writing the review, it had become evident that promising approaches to reducing unnecessary antibiotic administration in HAP other than comparing two fixed durations of therapy were being investigated, including procalcitonin‐guided therapy. For this reason we broadened the inclusion criteria from "RCTs comparing fixed durations of antibiotic therapy..." to also include: "or comparing a protocol intended to reduce duration of antibiotic therapy with standard care." Since this would involve studies with variable durations of therapy, it was felt important to include "Duration of antibiotic therapy" as a further outcome measure.

Our original intention was to exclude trials enrolling patients with haematological malignancy, chemically‐induced immune‐suppression or HIV/AIDS; this was subsequently revised to: "We intended to exclude data from patients with haematological malignancy, chemically‐induced immune‐suppression or HIV/AIDS where possible."

Lastly, anticipating potential variation in outcome reporting, other modifications to outcome measures included: separation of non‐resolution and recurrence outcomes and the addition of ICU mortality and duration of mechanical ventilation.

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.