Bromocriptine versus levodopa in early Parkinson's disease

van Hilten; Claudia C Ramaker; Rebecca Stowe; Natalie Ives

doi:10.1002/14651858.CD002258.pub2

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Analysis 1.1

Comparison 1 Occurrence of dyskinesias, Outcome 1 At one year.

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Analysis 1.2

Comparison 1 Occurrence of dyskinesias, Outcome 2 At two years.

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Analysis 1.3

Comparison 1 Occurrence of dyskinesias, Outcome 3 At three years.

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Analysis 1.4

Comparison 1 Occurrence of dyskinesias, Outcome 4 At four years.

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Analysis 1.5

Comparison 1 Occurrence of dyskinesias, Outcome 5 At five years.

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Analysis 2.1

Comparison 2 Occurrence of dystonia, Outcome 1 At one year.

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Analysis 2.2

Comparison 2 Occurrence of dystonia, Outcome 2 At two years.

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Analysis 2.3

Comparison 2 Occurrence of dystonia, Outcome 3 At three years.

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Analysis 2.4

Comparison 2 Occurrence of dystonia, Outcome 4 At four years.

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Analysis 2.5

Comparison 2 Occurrence of dystonia, Outcome 5 At five years.

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Analysis 3.3

Comparison 3 Occurrence of on/off‐fluctuations, Outcome 3 At three years.

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Analysis 3.5

Comparison 3 Occurrence of on/off‐fluctuations, Outcome 5 At five years.

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Analysis 4.1

Comparison 4 Occurrence of wearing‐off, Outcome 1 At one year.

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Analysis 4.2

Comparison 4 Occurrence of wearing‐off, Outcome 2 At two years.

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Analysis 4.3

Comparison 4 Occurrence of wearing‐off, Outcome 3 At three years.

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Analysis 4.4

Comparison 4 Occurrence of wearing‐off, Outcome 4 At four years.

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Analysis 4.5

Comparison 4 Occurrence of wearing‐off, Outcome 5 At five years.

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Analysis 5.1

Comparison 5 Withdrawal rate, Outcome 1 All causes.

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Analysis 5.2

Comparison 5 Withdrawal rate, Outcome 2 Lost to follow up.

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Analysis 5.3

Comparison 5 Withdrawal rate, Outcome 3 Poor compliance.

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Analysis 5.4

Comparison 5 Withdrawal rate, Outcome 4 Protocol violation.

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Analysis 5.5

Comparison 5 Withdrawal rate, Outcome 5 Lack of response.

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Analysis 5.6

Comparison 5 Withdrawal rate, Outcome 6 Deterioration.

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Analysis 5.7

Comparison 5 Withdrawal rate, Outcome 7 Adverse reaction.

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Analysis 5.8

Comparison 5 Withdrawal rate, Outcome 8 Revised diagnosis.

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Comparison 1. Occurrence of dyskinesias

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 At one year Show forest plot	2		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

2 At two years Show forest plot	2		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

3 At three years Show forest plot	3		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

4 At four years Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

5 At five years Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

Comparison 1. Occurrence of dyskinesias

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Comparison 2. Occurrence of dystonia

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 At one year Show forest plot	3		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

2 At two years Show forest plot	3		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

3 At three years Show forest plot	3		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

4 At four years Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

5 At five years Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

Comparison 2. Occurrence of dystonia

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Comparison 3. Occurrence of on/off‐fluctuations

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 At one year	0		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
2 At two years	0		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
3 At three years Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

4 At four years	0		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
5 At five years Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

Comparison 3. Occurrence of on/off‐fluctuations

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Comparison 4. Occurrence of wearing‐off

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 At one year Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

2 At two years Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

3 At three years Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

4 At four years Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

5 At five years Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

Comparison 4. Occurrence of wearing‐off

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Comparison 5. Withdrawal rate

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All causes Show forest plot	5		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

2 Lost to follow up Show forest plot	2		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

3 Poor compliance Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

4 Protocol violation Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

5 Lack of response Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

6 Deterioration Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

7 Adverse reaction Show forest plot	4		Peto Odds Ratio (Peto, Fixed, 95% CI)	Totals not selected

7.1 Hallucinations/confusion	2		Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
7.2 Nausea	2		Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
7.3 Orthostase	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
7.4 Other/unclear	2		Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
8 Revised diagnosis Show forest plot	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only

Comparison 5. Withdrawal rate

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