Scolaris Content Display Scolaris Content Display

Comparison 1 Occurrence of dyskinesias, Outcome 1 At one year.
Figures and Tables -
Analysis 1.1

Comparison 1 Occurrence of dyskinesias, Outcome 1 At one year.

Comparison 1 Occurrence of dyskinesias, Outcome 2 At two years.
Figures and Tables -
Analysis 1.2

Comparison 1 Occurrence of dyskinesias, Outcome 2 At two years.

Comparison 1 Occurrence of dyskinesias, Outcome 3 At three years.
Figures and Tables -
Analysis 1.3

Comparison 1 Occurrence of dyskinesias, Outcome 3 At three years.

Comparison 1 Occurrence of dyskinesias, Outcome 4 At four years.
Figures and Tables -
Analysis 1.4

Comparison 1 Occurrence of dyskinesias, Outcome 4 At four years.

Comparison 1 Occurrence of dyskinesias, Outcome 5 At five years.
Figures and Tables -
Analysis 1.5

Comparison 1 Occurrence of dyskinesias, Outcome 5 At five years.

Comparison 2 Occurrence of dystonia, Outcome 1 At one year.
Figures and Tables -
Analysis 2.1

Comparison 2 Occurrence of dystonia, Outcome 1 At one year.

Comparison 2 Occurrence of dystonia, Outcome 2 At two years.
Figures and Tables -
Analysis 2.2

Comparison 2 Occurrence of dystonia, Outcome 2 At two years.

Comparison 2 Occurrence of dystonia, Outcome 3 At three years.
Figures and Tables -
Analysis 2.3

Comparison 2 Occurrence of dystonia, Outcome 3 At three years.

Comparison 2 Occurrence of dystonia, Outcome 4 At four years.
Figures and Tables -
Analysis 2.4

Comparison 2 Occurrence of dystonia, Outcome 4 At four years.

Comparison 2 Occurrence of dystonia, Outcome 5 At five years.
Figures and Tables -
Analysis 2.5

Comparison 2 Occurrence of dystonia, Outcome 5 At five years.

Comparison 3 Occurrence of on/off‐fluctuations, Outcome 3 At three years.
Figures and Tables -
Analysis 3.3

Comparison 3 Occurrence of on/off‐fluctuations, Outcome 3 At three years.

Comparison 3 Occurrence of on/off‐fluctuations, Outcome 5 At five years.
Figures and Tables -
Analysis 3.5

Comparison 3 Occurrence of on/off‐fluctuations, Outcome 5 At five years.

Comparison 4 Occurrence of wearing‐off, Outcome 1 At one year.
Figures and Tables -
Analysis 4.1

Comparison 4 Occurrence of wearing‐off, Outcome 1 At one year.

Comparison 4 Occurrence of wearing‐off, Outcome 2 At two years.
Figures and Tables -
Analysis 4.2

Comparison 4 Occurrence of wearing‐off, Outcome 2 At two years.

Comparison 4 Occurrence of wearing‐off, Outcome 3 At three years.
Figures and Tables -
Analysis 4.3

Comparison 4 Occurrence of wearing‐off, Outcome 3 At three years.

Comparison 4 Occurrence of wearing‐off, Outcome 4 At four years.
Figures and Tables -
Analysis 4.4

Comparison 4 Occurrence of wearing‐off, Outcome 4 At four years.

Comparison 4 Occurrence of wearing‐off, Outcome 5 At five years.
Figures and Tables -
Analysis 4.5

Comparison 4 Occurrence of wearing‐off, Outcome 5 At five years.

Comparison 5 Withdrawal rate, Outcome 1 All causes.
Figures and Tables -
Analysis 5.1

Comparison 5 Withdrawal rate, Outcome 1 All causes.

Comparison 5 Withdrawal rate, Outcome 2 Lost to follow up.
Figures and Tables -
Analysis 5.2

Comparison 5 Withdrawal rate, Outcome 2 Lost to follow up.

Comparison 5 Withdrawal rate, Outcome 3 Poor compliance.
Figures and Tables -
Analysis 5.3

Comparison 5 Withdrawal rate, Outcome 3 Poor compliance.

Comparison 5 Withdrawal rate, Outcome 4 Protocol violation.
Figures and Tables -
Analysis 5.4

Comparison 5 Withdrawal rate, Outcome 4 Protocol violation.

Comparison 5 Withdrawal rate, Outcome 5 Lack of response.
Figures and Tables -
Analysis 5.5

Comparison 5 Withdrawal rate, Outcome 5 Lack of response.

Comparison 5 Withdrawal rate, Outcome 6 Deterioration.
Figures and Tables -
Analysis 5.6

Comparison 5 Withdrawal rate, Outcome 6 Deterioration.

Comparison 5 Withdrawal rate, Outcome 7 Adverse reaction.
Figures and Tables -
Analysis 5.7

Comparison 5 Withdrawal rate, Outcome 7 Adverse reaction.

Comparison 5 Withdrawal rate, Outcome 8 Revised diagnosis.
Figures and Tables -
Analysis 5.8

Comparison 5 Withdrawal rate, Outcome 8 Revised diagnosis.

Comparison 1. Occurrence of dyskinesias

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 At one year Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

2 At two years Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3 At three years Show forest plot

3

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4 At four years Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5 At five years Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

Figures and Tables -
Comparison 1. Occurrence of dyskinesias
Comparison 2. Occurrence of dystonia

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 At one year Show forest plot

3

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

2 At two years Show forest plot

3

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3 At three years Show forest plot

3

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4 At four years Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5 At five years Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

Figures and Tables -
Comparison 2. Occurrence of dystonia
Comparison 3. Occurrence of on/off‐fluctuations

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 At one year

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

2 At two years

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3 At three years Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4 At four years

0

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5 At five years Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

Figures and Tables -
Comparison 3. Occurrence of on/off‐fluctuations
Comparison 4. Occurrence of wearing‐off

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 At one year Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

2 At two years Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3 At three years Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4 At four years Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5 At five years Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

Figures and Tables -
Comparison 4. Occurrence of wearing‐off
Comparison 5. Withdrawal rate

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 All causes Show forest plot

5

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

2 Lost to follow up Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

3 Poor compliance Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

4 Protocol violation Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5 Lack of response Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

6 Deterioration Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

7 Adverse reaction Show forest plot

4

Peto Odds Ratio (Peto, Fixed, 95% CI)

Totals not selected

7.1 Hallucinations/confusion

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.2 Nausea

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.3 Orthostase

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.4 Other/unclear

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Revised diagnosis Show forest plot

1

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

Figures and Tables -
Comparison 5. Withdrawal rate