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Induced hypertension for preventing complications of delayed cerebral ischaemia in aneurysmal subarachnoid haemorrhage

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Versión publicada: 14 noviembre 2017 Historial de versiones

https://doi.org/10.1002/14651858.CD012842

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Table 1. 'Summary of findings' table template

Induced hypertension versus no induced hypertension in people with aneurysmal subarachnoid haemorrhage (SAH)

Participants: people with aneurysmal subarachnoid haemorrhage documented by CT scan, who underwent treatment of the aneurysm (either surgical clipping or intraluminal coiling) and entered the trial within 2 weeks after the SAH

Setting: hospital

Intervention: induced hypertension

Comparison: without induced hypertension

Outcomes

Absolute risk

Comparative risk (95% CI)

Relative effect (95% CI)

Number of participants

(studies)

Quality of the evidence

(GRADE)

Comments

Unfavourable outcome1 (90 days)

Death (any cause) at 90 days; in the intensive care unit; in hospital

Unfavourable outcome1 (6 months)

Incidence of DCI and vasospasm‐related complications within 3 weeks of the SAH

Cerebral infarction2

Re‐bleeding3

Complications of intervention4

Physiological outcome measures5

Abbreviations: CT scan: computed tomography scan; MRI scan: magnetic resonance imaging scan; SAH: subarachnoid haemorrhage; DCI: delayed cerebral ischaemia; CI: confidence interval; RR: risk ratio; GRADE: Grading of Recommendations Assessment, Development and Evaluation; MAP: mean arterial blood pressure.

1Unfavourable outcome: death, persistent vegetative state, or severe disability (modified Rankin Scale (mRS) score 4 to 6, Extended Glasgow Outcome Scale (GOSE) 4 to 6 or equivalent) at 90 days after SAH.
2Established cerebral infarction at any time within 90 days after SAH, confirmed radiologically by CT or MRI scan.
3Recurrent haemorrhage during the intervention or within 24 hours after the intervention.
4Complications of intervention, defined as a clinical deterioration observed during the intervention or within 24 hours after the intervention. These complications include arrhythmias, cardiac ischaemia, mesenteric ischaemia, digital ischaemia, and haemorrhagic stroke unrelated to the primary disease.
5Physiological outcome measures during the intervention or within 24 hours after the intervention. These include cerebral blood flow (CBF), cerebral perfusion pressure, cerebral tissue oxygenation, cerebral microdialysis, cardiac output and mean arterial blood pressure (MAP).

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Table 1. 'Summary of findings' table template
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