Objective

Intervention

Control

Are higher doses more effective (0.5 mg/kg or 30 mg primaquine/day for 14 days), in all areas, or only in areas where they are standard treatment (Asia, Pacific)?

Blood‐stage antimalarial drug with primaquine 0.5 mg/kg (30 mg) per day for 14 days (total dose 420 mg)

Both intervention and control groups must have received the same treatment: either CQ or ACT for the blood‐borne stage of infection.

Blood‐stage antimalarial drug with primaquine 0.25 mg/kg (15 mg) per day for 14 days (total dose 210 mg)

Both intervention and control groups must have received the same treatment: either CQ or ACT for the blood‐borne stage of infection.

Are shorter, higher dose regimes of primaquine over 7 days as effective as treatment over 14 days (is the total dose rather than the length of treatment the important factor)?

Blood‐stage antimalarial drug with primaquine 0.5 mg/kg (30 mg) per day for 7 days (total dose 210 mg)

Both intervention and control groups must have received the same treatment: either CQ or ACT for the blood‐borne stage of infection.

Are weekly dosing regimens (0.75 mg/kg or 45 mg/week for 8 weeks) as effective?

Blood‐stage antimalarial drug with primaquine 0.75/kg (45 mg) per week for 8 weeks (total dose 360 mg)