Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer patients with anaemia: A systematic review and network meta‐analysis
Appendices
Appendix 1. MEDLINE search strategies
MEDLINE/Ovid (included Epub Ahead of Print, In‐Process & Other Non‐Indexed Citations)
Search Strategy:
| # | Searches |
| 1 | exp ANEMIA/dt, th [Drug Therapy, Therapy] |
| 2 | anaemia$.tw,kf,ot. |
| 3 | anemia$.tw,kf,ot. |
| 4 | ((anemi$ or anaemi$) adj3 cancer).tw,kf,ot. |
| 5 | or/1‐4 |
| 6 | ANEMIA, IRON‐DEFICIENCY/ |
| 7 | Iron/ |
| 8 | IRON COMPOUNDS/ |
| 9 | exp FERRIC COMPOUNDS/ |
| 10 | FERROUS COMPOUNDS/ |
| 11 | iron$.tw,kf,ot. |
| 12 | iron$.sh. |
| 13 | ferri$.tw,kf,ot. |
| 14 | (ferro$ adj2 (compound$ or compund$)).tw,kf,ot. |
| 15 | hemosider$.tw,kf,ot. |
| 16 | sideros$.tw,kf,ot. |
| 17 | transferrin$.tw,kf,ot. |
| 18 | or/6‐17 |
| 19 | 5 or 18 |
| 20 | exp NEOPLASMS BY HISTOLOGIC TYPE/ |
| 21 | exp NEOPLASMS BY SITE/ |
| 22 | neoplas$.tw,kf,ot. |
| 23 | tumo?r$.tw,kf,ot. |
| 24 | (Krebs$ or cancer$).tw,kf,ot. |
| 25 | malignan$.tw,kf,ot. |
| 26 | (carcino$ or karzino$).tw,kf,ot. |
| 27 | karzinom$.tw,kf,ot. |
| 28 | sarcom$.tw,kf,ot. |
| 29 | leuk#?m$.tw,kf,ot. |
| 30 | lymphom$.tw,kf,ot. |
| 31 | melano$.tw,kf,ot. |
| 32 | metastas$.tw,kf,ot. |
| 33 | (mesothelio$ or mesotelio$).tw,kf,ot. |
| 34 | carcinomatos$.tw,kf,ot. |
| 35 | (gliom$ or glioblastom$).tw,kf,ot. |
| 36 | osteo?sarcom$.tw,kf,ot. |
| 37 | (blastom$ or neuroblastom$).tw,kf,ot. |
| 38 | oncol$.tw. |
| 39 | myelodysplas$.tw. |
| 40 | or/20‐39 |
| 41 | chemotherapy.mp. |
| 42 | exp ANTINEOPLASTIC AGENTS/ |
| 43 | REMISSION INDUCTION/ |
| 44 | exp ANTINEOPLASTIC PROTOCOLS/ |
| 45 | ((consolidat$ or induct$ or maintenance or conditioning$) and (therap$ or treat$ or regimen$ or patient$)).tw,kf,ot. |
| 46 | ((anticancer$ or cancer$) adj2 (therap$ or treat$)).tw,kf,ot. |
| 47 | (remission$ adj2 therap$).tw,kf,ot. |
| 48 | (remission$ adj2 induction$).tw,kf,ot. |
| 49 | (chemotherap$ or chemo‐therap$).tw,kf,ot. |
| 50 | (Antineoplast$ or anti‐neoplast$).tw,kf,ot. |
| 51 | ((cytosta$ or cytotox$) adj2 (therap$ or treat$ or regimen$)).tw,kf,ot. |
| 52 | or/41‐51 |
| 53 | randomized controlled trial.pt. |
| 54 | controlled clinical trial.pt. |
| 55 | randomi?ed.ab. |
| 56 | placebo.ab. |
| 57 | clinical trials as topic.sh. |
| 58 | randomly.ab. |
| 59 | trial.ti. |
| 60 | or/53‐59 |
| 61 | humans.sh. |
| 62 | 60 and 61 |
| 63 | 40 or 52 |
| 64 | 19 and 63 |
| 65 | 64 and 62 |
| 66 | limit 65 to ed=20151116‐20170107 |
MEDLINE/Ovid Search Strategy:
| # | Searches |
| 1 | exp ERYTHROPOIETIN/ |
| 2 | erythropoietin.mp. |
| 3 | erythropoiesis.mp. |
| 4 | exp EPOETIN ALFA/ |
| 5 | epoetin.mp. |
| 6 | epo.mp. |
| 7 | epoetin alfa.mp. |
| 8 | epoetin beta.mp. |
| 9 | eprex.mp. |
| 10 | neorecormon.mp. |
| 11 | aranesp.mp. |
| 12 | procrit.mp. |
| 13 | recombinant erythropoietin.mp. |
| 14 | darbepoetin alfa.mp. |
| 15 | darbepoetin.mp. |
| 16 | RECEPTORS, ERYTHROPOIETIN/ |
| 17 | CERA.mp. |
| 18 | epoetin theta.mp. |
| 19 | epoetin zeta.mp. |
| 20 | silapo*.tw,kf,nm,ot. |
| 21 | retacrit*.tw,kf,nm,ot. |
| 22 | biopoin*.tw,kf,nm,ot. |
| 23 | eporatio*.tw,kf,nm,ot. |
| 24 | or/1‐23 |
| 25 | anaemia.mp. |
| 26 | anemia.mp. |
| 27 | (anemi* adj3 cancer).mp. |
| 28 | (anaemi* adj3 cancer).mp. |
| 29 | or/25‐28 |
| 30 | ANEMIA, IRON‐DEFICIENCY/ |
| 31 | IRON/ |
| 32 | IRON COMPOUNDS/ |
| 33 | iron*.sh. |
| 34 | iron*.tw,kf,ot. |
| 35 | ferri*.tw,kf,ot. |
| 36 | (ferro* adj2 (compound* or compund*)).tw,kf,ot. |
| 37 | hemosider*.tw,kf,ot. |
| 38 | sideros*.tw,kf,ot. |
| 39 | transferrin*.tw,kf,ot. |
| 40 | or/30‐39 |
| 41 | exp NEOPLASMS/ |
| 42 | malignan*.mp. |
| 43 | cancer*.mp. |
| 44 | oncolog*.tw. |
| 45 | myelodysplas*.tw. |
| 46 | chemotherapy.mp. |
| 47 | tumo?r*.mp. |
| 48 | carcinom*.mp. |
| 49 | or/41‐48 |
| 50 | exp ANTINEOPLASTIC AGENTS/ |
| 51 | REMISSION INDUCTION/ |
| 52 | exp ANTINEOPLASTIC PROTOCOLS/ |
| 53 | ((consolidat* or induct* or maintenance or conditioning*) and (therap* or treat* or regimen* or patient*)).tw,kf,ot. |
| 54 | ((anticancer* or cancer*) adj2 (therap* or treat*)).tw,kf,ot. |
| 55 | (remission* adj2 therap*).tw,kf,ot. |
| 56 | (remission* adj2 induction*).tw,kf,ot. |
| 57 | (chemotherap* or chemo‐therap*).tw,kf,ot. |
| 58 | (Antineoplast* or anti‐neoplast*).tw,kf,ot. |
| 59 | ((cytosta* or cytotox*) adj2 (therap* or treat* or regimen*)).tw,kf,ot. |
| 60 | or/50‐59 |
| 61 | randomized controlled trial.pt. |
| 62 | controlled clinical trial.pt. |
| 63 | randomi?ed.ab. |
| 64 | placebo.ab. |
| 65 | drug therapy.fs. |
| 66 | randomly.ab. |
| 67 | trial.ab. |
| 68 | groups.ab. |
| 69 | or/61‐68 |
| 70 | humans.sh. |
| 71 | 69 and 70 |
| 72 | 60 and 71 |
| 73 | 24 and 29 and 40 |
| 74 | 73 and 49 |
| 75 | 73 and 60 |
| 76 | 74 or 75 |
| 77 | 76 and 71 |
Appendix 2. CENTRAL search strategies
Cochrane Central Register of Controlled Trials
#1 MESH DESCRIPTOR ANEMIA EXPLODE ALL TREES
#2 anaemia:TI,AB,KY
#3 anemia:TI,AB,KY
#4 (((anemi* or anaemi*) adj3 cancer)):TI,AB,KY
#5 #1 OR #2 OR #3 OR #4
#6 MESH DESCRIPTOR Anemia, Iron‐Deficiency EXPLODE ALL TREES
#7 MESH DESCRIPTOR Iron EXPLODE ALL TREES
#8 MESH DESCRIPTOR Iron Compounds EXPLODE ALL TREES
#9 MESH DESCRIPTOR Ferric Compounds EXPLODE ALL TREES
#10 MESH DESCRIPTOR Ferrous Compounds EXPLODE ALL TREES
#11 iron*:TI,AB,KY
#12 ferri*:TI,AB,KY
#13 ((ferro* adj2 (compound* or compund*))):TI,AB,KY
#14 hemosider*:TI,AB,KY
#15 sideros*:TI,AB,KY
#16 transferrin*:TI,AB,KY
#17 #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16
#18 #5 OR #17
#19 MESH DESCRIPTOR NEOPLASMS BY HISTOLOGIC TYPE EXPLODE ALL TREES
#20 MESH DESCRIPTOR NEOPLASMS BY SITE EXPLODE ALL TREES
#21 neoplas*:TI,AB,KY
#22 ((tumor* OR tumour*)):TI,AB,KY
#23 ((Krebs* or cancer*)):TI,AB,KY
#24 malignan*:TI,AB,KY
#25 ((carcino* or karzino*)):TI,AB,KY
#26 karzinom*:TI,AB,KY
#27 sarcom*:TI,AB,KY
#28 (leukem* OR leukaemi* OR leucem*):TI,AB,KY
#29 lymphom*:TI,AB,KY
#30 melano*:TI,AB,KY
#31 metastas*:TI,AB,KY
#32 (mesothelio* OR mesotelio*):TI,AB,KY
#33 carcinomatos*:TI,AB,KY
#34 ((gliom* or glioblastom*)):TI,AB,KY
#35 osteo*sarcom*:TI,AB,KY
#36 ((blastom* or neuroblastom*)):TI,AB,KY
#37 oncol*:TI,AB,KY
#38 myelodysplas*:TI,AB,KY
#39 #19 OR #20 OR #21 OR #22 OR #23 OR #24 OR #25 OR #26 OR #27 OR #28 OR #29 OR #30 OR #31 OR #32 OR #33 OR #34 OR #35 OR #36 OR #37 OR #38
#40 MESH DESCRIPTOR Antineoplastic Agents EXPLODE ALL TREES
#41 MESH DESCRIPTOR Remission Induction EXPLODE ALL TREES
#42 MESH DESCRIPTOR antineoplastic protocols EXPLODE ALL TREES
#43 ((((consolidat* or induct* or maintenance or conditioning*) and (therap* or treat* or regimen* or patient*)))):TI,AB,KY
#44 ((((anticancer* or cancer*) adj2 (therap* or treat*)))):TI,AB,KY
#45 (((remission* adj2 therap*))):TI,AB,KY
#46 (((remission* adj2 induction*))):TI,AB,KY
#47 (((chemotherap* or chemo‐therap*))):TI,AB,KY
#48 (((Antineoplast* or anti‐neoplast*))):TI,AB,KY
#49 ((((cytosta* or cytotox*) adj2 (therap* or treat* or regimen*)))):TI,AB,KY
#50 #40 or #41 or #42 or #43 or #44 or #45 or #46 or #47 or #48 or #49
#51 #39 or #50
#52 #18 and #51
Cochrane Central Register of Controlled Trials Search Strategy
ID Search
#1 MeSH descriptor: [Erythropoietin] explode all trees
#2 erythropoietin
#3 erythropoiesis
#4 MeSH descriptor: [Epoetin Alfa] explode all trees
#5 epoetin
#6 epo
#7 epoetin alfa
#8 epoetin beta
#9 eprex
#10 neorecormon
#11 aranesp
#12 procrit
#13 recombinant erythropoietin
#14 darbepoetin alfa
#15 darbepoetin
#16 MeSH descriptor: [Receptors, Erythropoietin] explode all trees
#17 CERA
#18 epoetin theta
#19 epoetin zeta
#20 silapo*
#21 retacrit*
#22 biopoin*
#23 eporatio*
#24 #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23
#25 anaemia
#26 anemia
#27 (anemi* near/3 cancer)
#28 (anaemi* near/3 cancer)
#29 #25 or #26 or #27 or #28
#30 MeSH descriptor: [Anemia, Iron‐Deficiency] explode all trees
#31 MeSH descriptor: [Iron] explode all trees
#32 MeSH descriptor: [Iron Compounds] explode all trees
#33 iron*
#34 ferri*
#35 (ferro* near/2 (compound* or compund*))
#36 hemosider*
#37 sideros*
#38 transferrin*
#39 #30 or #31 or #32 or #33 or #34 or #35 or #36 or #37 or #38
#40 MeSH descriptor: [Neoplasms] explode all trees
#41 malignan*
#42 cancer*
#43 oncolog*
#44 myelodysplas*
#45 chemotherapy
#46 tumor* or tumour*
#47 carcinom*
#48 #40 or #41 or #42 or #43 or #44 or #45 or #46 or #47
#49 MeSH descriptor: [Antineoplastic Agents] explode all trees
#50 MeSH descriptor: [Remission Induction] explode all trees
#51 MeSH descriptor: [Antineoplastic Protocols] explode all trees
#52 ((consolidat* or induct* or maintenance or conditioning*) and (therap* or treat* or regimen* or patient*))
#53 ((anticancer* or cancer*) near/2 (therap* or treat*))
#54 (remission* near/2 therap*)
#55 (remission* near/2 induction*)
#56 (chemotherap* or chemo‐therap*)
#57 (Antineoplast* or anti‐neoplast*)
#58 ((cytosta* or cytotox*) near/2 (therap* or treat* or regimen*))
#59 #49 or #50 or #51 or #52 or #53 or #54 or #55 or #56 or #57 or #58
#60 #24 and #29 and #39
#61 #60 and #48
#62 #60 and #59
#63 #61 or #62, in Trials
