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Base de datos Cochrane de Revisiones Sistemáticas Protocolo - Intervención

Intermittent versus continuous systemic therapy as treatment for unresectable metastatic colorectal cancer

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Versión publicada: 21 diciembre 2016 Historial de versiones

https://doi.org/10.1002/14651858.CD012440

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Study flow diagram.
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Study flow diagram.

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Non‐inferiority interpretation of meta‐analysis findings
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Non‐inferiority interpretation of meta‐analysis findings

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Planned subgroup analysis
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Planned subgroup analysis

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Table 1. Table 1

Table 1. Examples of intermittent versus continuous treatment schemes

1.

Intermittent: FOLFOX17, 12 weeks; sLV5‐FU22, 24 weeks; FOLFOX7, 12 weeks

Continuous: FOLFOX4 every 2 weeks until progression of disease (PD) (Tournigand 2004)

2.

Intermittent: FOLFIRI3, 12 weeks; chemotherapy‐Free‐Interval (CFI); restart FOLFIRI at PD

Continuous: FOLFIRI, 24 weeks (Alexopoulos 2006)

3.

Intermittent: Bevacizumab + capecitabine/oxaliplatin, 18 weeks; CFI; restart Bevacizumab+ capecitabine/oxaliplatin at PD

Continuous: Bevacizumab + capecitabine/oxaliplatin, 18 weeks; bevacizumab+capecitabine, restart bevacizumab+capecitabine/oxaliplatin at PD (Simkens 2015)

1 FOLFOX: FOL: folinic acid; F: fluorouracil (5‐FU); OX: oxaliplatin.
2 sLV5‐FU2: simplified leucovorin plus bolus and infusional fluorouracil.
3 FOLFIRI: FOL: folinic acid; F: fluorouracil (5‐FU); IRI: irinotecan.

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Table 1. Table 1
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