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Cochrane Database of Systematic Reviews

Monoterapia con ribavirina para la hepatitis C crónica

Información

DOI:
https://doi.org/10.1002/14651858.CD005527.pub2Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 07 octubre 2009see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:

  1. Grupo Cochrane de Hepatobiliar

Copyright:
  1. Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Contraer

Autores

  • Jesper Brok

    Correspondencia a: Cochrane Hepato‐Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

    [email protected]

    [email protected]

  • Lise Lotte Gluud

    Cochrane Hepato‐Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

  • Christian Gluud

    Cochrane Hepato‐Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Contributions of authors

JB performed the searches and drafted the updated review. JB and LLG performed the trial selection, data extraction, and data analyses. LLG, JB, and CG performed the statistical analyses. LLG and CG revised the updated review.

Sources of support

Internal sources

  • The Copenhagen Trial Unit, Copenhagen Hospital Corporation, Denmark.

External sources

  • The Danish Medical Research Council, Denmark.

  • The 1991 Pharmacy Foundation, Denmark.

  • Danish Institute for Health Technology Assessment, Denmark.

  • Department of Health Incentive Scheme for Updating Cochrane Reviews, UK.

Declarations of interest

The authors have no financial, personal, or academic affiliations, which may be construed as a conflict of interest.

Acknowledgements

We primarily extend our acknowledgement to the patients who took part in and the researchers who designed and performed the reviewed trials. We are also indebted to Dimitrinka Nikolova, Sarah Louise Klingenberg, and Nader Salas for their expert assistance in the identification of trials and to Ninna Frydendall and Bitten Hansen for secretarial assistance.

Peer Reviewers: Flavio Lirussi, Italy; Fabio Farinati, Italy.
Contact Editors: Ronald L Koretz, USA.

Version history

Published

Title

Stage

Authors

Version

2009 Oct 07

Ribavirin monotherapy for chronic hepatitis C

Review

Jesper Brok, Lise Lotte Gluud, Christian Gluud

https://doi.org/10.1002/14651858.CD005527.pub2

2009 Jul 08

Ribavirin monotherapy for chronic hepatitis C

Review

Jesper Brok, Lise Lotte Gluud, Christian Gluud

https://doi.org/10.1002/14651858.CD005527

Differences between protocol and review

We now assess our data from the cumulative meta‐analyses by trial sequential analyses by trial sequential analysis in order to estimate how far from a realistic size we are, and in order to reduce spurious significant findings due to random errors and multiplicity from repetitive testing (Wetterslev 2008).

Notes

This is the second update of the Cochrane review originally entitled 'Ribavirin with or without alpha interferon versus no intervention, placebo or alpha interferon for chronic hepatitis C', first published in The Cochrane Library 2002, Issue 1. Due to an additional large number of included trials, the review was, at the first update, split into two reviews entitled 'Ribavirin monotherapy for chronic hepatitis C' and 'Ribavirin plus interferon versus interferon for chronic hepatitis C'. The latter is published for the first time in Issue 3, 2005.

In the last updated review from 2005 changes have been made in:

Background
This section is updated and written according to the recommendations of RevMan 5 (RevMan 2008).

Electronic searches
We also search the Science Citation Index Expanded and searched for ongoing trial and unpublished trials in clinical trial databases: (http://controlled‐trials.com, http://clinicaltrials.gov, and http://centerwatch.com). The updated search revealed one new trial (Sostegni 1998), and we identified a full publication of a previously included abstract (Pawlotsky 2004).

Statistical analyses
The occurrence of events in the primary outcomes was nil in a number of trials. We, therefore, decided in the updated review to analyse data with risk difference (RD) as this analyses includes trials with no events in the overall analysis.

Bias assessment
Bias assessment of each trial now includes assessment of incomplete outcome data, baseline imbalance, early stopping, and source of funding bias according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions (Higgins 2008).

Conclusion
The overall conclusion has not been changed.