Effects and safety of preventive oral iron or iron+folic acid supplementation for women during pregnancy
Información
- DOI:
- https://doi.org/10.1002/14651858.CD004736.pub3Copiar DOI
- Base de datos:
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- Cochrane Database of Systematic Reviews
- Versión publicada:
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- 07 octubre 2009see what's new
- Tipo:
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- Intervention
- Etapa:
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- Review
- Grupo Editorial Cochrane:
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Grupo Cochrane de Embarazo y parto
- Copyright:
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- Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Cifras del artículo
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Autores
Contributions of authors
Juan Pablo Pena‐Rosas and Fernando Viteri co‐wrote the protocol, the review and the update. Juan Pablo Pena‐Rosas abstracted the trial data and carried out the analysis with the technical support and guidance of Fernando Viteri. Both took primary responsibility in producing the final manuscript.
Disclaimer: Juan Pablo Pena‐Rosas is currently a staff member of the World Health Organization. The authors alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions, policy or views of the World Health Organization.
Sources of support
Internal sources
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Children's Hospital and Oakland Research Institute (CHORI), USA.
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International Micronutrient Malnutrition Prevention and Control Program (IMMPaCt) ‐ U.S. Centers for Disease Control and Prevention (CDC), USA.
External sources
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Department of Reproductive Health and Research, World Health Organization (WHO), Switzerland.
Declarations of interest
We certify that we have no affiliations with or involvement in any organisation or entity with a direct financial interest in the subject matter of the review (e.g. employment, consultancy, stock ownership, honoraria, expert testimony).
Fernando Viteri was involved in some included studies with intermittent iron supplementation. Juan Pablo Pena‐Rosas was author of an excluded study on iron and folic acid intermittent supplementation.
Acknowledgements
We would like to thank the trial authors who have contributed additional data for this review; and Richard Riley who provided statistical advice. In addition, we would like to thank the staff at the editorial office of the Cochrane Pregnancy and Childbirth Group in Liverpool for their support in the preparation of this review and, in particular, Professor Zarko Alfirevic.
As part of the pre‐publication editorial process, this update has been commented on by three peers (an editor, and two referees who are external to the editorial team) and the Group's Statistical Adviser.
Version history
| Published | Title | Stage | Authors | Version |
| 2015 Jul 22 | Daily oral iron supplementation during pregnancy | Review | Juan Pablo Peña‐Rosas, Luz Maria De‐Regil, Maria N Garcia‐Casal, Therese Dowswell | |
| 2012 Dec 12 | Daily oral iron supplementation during pregnancy | Review | Juan Pablo Peña‐Rosas, Luz Maria De‐Regil, Therese Dowswell, Fernando E Viteri | |
| 2009 Oct 07 | Effects and safety of preventive oral iron or iron+folic acid supplementation for women during pregnancy | Review | Juan Pablo Peña‐Rosas, Fernando E Viteri | |
| 2009 Jul 08 | Effects of routine oral iron supplementation with or without folic acid for women during pregnancy | Review | Juan Pablo Peña‐Rosas, Fernando E Viteri | |
| 2004 Apr 19 | Oral iron supplementation with or without folic acid for women during pregnancy | Protocol | Juan P Pena‐Rosas, Fernando Viteri, Kassam Mahomed | |
Differences between protocol and review
This review aims to evaluate the effectiveness of supplementation with iron alone or in combination with folic acid on functional outcomes in the mother and the infant rather than just haematological indicators. It also evaluates the regimen schedules by comparing intermittent (less frequent than daily) supplement intake with the standard daily regimens and the effects of these interventions on side‐effects and haemoconcentration. Unlike the previous version of this review, in this updated version, trials assessing the effect of iron or folic acid when given in combination with other micronutrients were included as long as both groups being compared in the daily regimens received the same other micronutrient interventions, which has led to some previously excluded studies now being included.
The comparisons in this review were reduced to four instead of eight as stated in the original protocol. The subgroup analyses were considered only for the primary outcomes.
