Duration of treatment for asymptomatic bacteriuria during pregnancy

Mariana Widmer; A Metin Gülmezoglu; Luciano Mignini; Ariel Roganti

doi:10.1002/14651858.CD000491.pub2

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Figure 1

Funnel plot of comparison: 1 Single dose versus short‐course (4‐7 day) antibiotic for asymptomatic bacteriuria, outcome: 1.6 No cure.

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Analysis 1.1

Comparison 1 Single dose versus short‐course (4‐7 day) antibiotic for asymptomatic bacteriuria, Outcome 1 No cure.

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Analysis 1.2

Comparison 1 Single dose versus short‐course (4‐7 day) antibiotic for asymptomatic bacteriuria, Outcome 2 Preterm delivery.

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Analysis 1.3

Comparison 1 Single dose versus short‐course (4‐7 day) antibiotic for asymptomatic bacteriuria, Outcome 3 Preterm delivery or low birthweight.

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Analysis 1.4

Comparison 1 Single dose versus short‐course (4‐7 day) antibiotic for asymptomatic bacteriuria, Outcome 4 Pyelonephritis.

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Analysis 1.5

Comparison 1 Single dose versus short‐course (4‐7 day) antibiotic for asymptomatic bacteriuria, Outcome 5 Side effects.

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Analysis 1.6

Comparison 1 Single dose versus short‐course (4‐7 day) antibiotic for asymptomatic bacteriuria, Outcome 6 Recurrent asymptomatic bacteriuria.

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Comparison 1. Single dose versus short‐course (4‐7 day) antibiotic for asymptomatic bacteriuria

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 No cure Show forest plot	13	1502	Risk Ratio (M‐H, Random, 95% CI)	1.33 [0.88, 2.01]

1.1 Same antimicrobial agent	10	1286	Risk Ratio (M‐H, Random, 95% CI)	1.43 [0.87, 2.34]
1.2 Different antimicrobial agents	3	216	Risk Ratio (M‐H, Random, 95% CI)	0.98 [0.49, 1.95]
2 Preterm delivery Show forest plot	3	804	Risk Ratio (M‐H, Random, 95% CI)	1.09 [0.52, 2.26]

2.1 Same antimicrobial agent	3	804	Risk Ratio (M‐H, Random, 95% CI)	1.09 [0.52, 2.26]
3 Preterm delivery or low birthweight Show forest plot	1	714	Risk Difference (M‐H, Random, 95% CI)	0.05 [0.01, 0.10]

3.1 Same antimicrobial agent	1	714	Risk Difference (M‐H, Random, 95% CI)	0.05 [0.01, 0.10]
4 Pyelonephritis Show forest plot	2	102	Risk Ratio (M‐H, Random, 95% CI)	2.97 [0.51, 17.28]

4.1 Same antimicrobial agent	2	102	Risk Ratio (M‐H, Random, 95% CI)	2.97 [0.51, 17.28]
5 Side effects Show forest plot	12	1460	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.56, 0.88]

5.1 Same antimicrobial agent	9	1244	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.61, 0.97]
5.2 Different antimicrobial agents	3	216	Risk Ratio (M‐H, Fixed, 95% CI)	0.16 [0.04, 0.58]
6 Recurrent asymptomatic bacteriuria Show forest plot	8	445	Risk Ratio (M‐H, Random, 95% CI)	1.09 [0.75, 1.60]

6.1 Same antimicrobial agent	6	313	Risk Ratio (M‐H, Random, 95% CI)	1.08 [0.74, 1.60]
6.2 Different antimicrobial agents	2	132	Risk Ratio (M‐H, Random, 95% CI)	1.32 [0.23, 7.55]
7 Need for repeat treatment	0	0	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]

Comparison 1. Single dose versus short‐course (4‐7 day) antibiotic for asymptomatic bacteriuria

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