Appendix 1. CENTRAL search strategy

ID Search

#1 MeSH descriptor: [Antiemetics] explode all trees

#2 (antiemetic* or anti emetic*)

#3 #1 or #2

#4 MeSH descriptor: [Serotonin Antagonists] explode all trees

#5 (5 ht antagonist* or 5ht antagonist*)

#6 (serotonin* near/3 (antagonist* or blockader* or blocker*))

#7 (antiserotonergic* near/2 agent*)

#8 #4 or #5 or #6 or #7

#9 MeSH descriptor: [Serotonin 5‐HT3 Receptor Antagonists] explode all trees

#10 ((5 ht3 or 5ht3) near/2 antagonist*)

#11 #9 or #10

#12 MeSH descriptor: [Granisetron] explode all trees

#13 Granisetron*

#14 (brl‐43694a or brl43694a or brl‐43694 or brl43694)

#15 Kytril*

#16 Sancuso*

#17 #12 or #13 or #14 or #15 or #16

#18 MeSH descriptor: [Ondansetron] explode all trees

#19 Ondansetron*

#20 (gr38032f or gr 38032f)

#21 (sn 307 or sn307)

#22 Zofran*

#23 #18 or #19 or #20 or #21 or #22

#24 Tropisetron*

#25 Navoban*

#26 (ICS 205‐930 or ICS 205930)

#27 #24 or #25 or #26

#28 Dolasetron*

#29 Anzemet*

#30 #28 or #29

#31 Palonosetron*

#32 Aloxi*

#33 #31 or #32

#34 Zatosetron*

#35 (LY277359 or ly 277359)

#36 #34 or #35

#37 Ricasetron*

#38 (BRL‐46470 or BRL46470)

#39 #37 or #38

#40 Bemesetron*

#41 (MDL‐72222 or MDL72222)

#42 #40 or #41

#43 Ramosetron*

#44 Nasea*

#45 (Irribow* or Iribo*)

#46 (Nozia* or IBSet*)

#47 (Ai Ke An* or Lei Mai Xin* or Shan Chen*)

#48 ("Ramea" or Setoral*)

#49 #43 or #44 or #45 or #46 or #47 or #48

#50 "metastron"

#51 (strontium chloride‐89 or Sr‐89)

#52 #50 or #51

#53 itastron*

#54 setron*

#55 #53 or #54

#56 Aprepitant*

#57 Emend*

#58 #56 or #57

#59 Fosaprepitant*

#60 (L‐758,298 or L‐758298)

#61 Fosa

#62 #59 or #60 or #61

#63 Netupitant*

#64 Akynzeo*

#65 "nepa"

#66 #63 or #64 or #65

#67 MeSH descriptor: [Dexamethasone] explode all trees

#68 decameth*

#69 Dexamethason*

#70 Dexamethasone

#71 desamethason*

#72 (dexason* or dexadrol* or dexair* or dexacidin* or dxm*)

#73 (oradexon* or maxidex* or maxitrol* or tobradex* or ak‐dex*)

#74 (hexadecadrol* or oradexon* or decadron* or neodecadron*)

#75 dexametason*

#76 desametason*

#77 (millicorten* or maxidex* or decaspray* or dexpak*)

#78 (hexadrol* or decameth* or methylfluorprednisolon*)

#79 decaject*

#80 #67 or #68 or #69 or #70 or #71 or #72 or #73 or #74 or #75 or #76 or #77 or #78 or #79

#81 MeSH descriptor: [Nausea] explode all trees

#82 MeSH descriptor: [Vomiting] explode all trees

#83 nause*

#84 vomit*

#85 emesis

#86 emet*

#87 emetogenic*

#88 (antiemetic* or anti‐eme*)

#89 sickness*

#90 #81 or #82 or #83 or #84 or #85 or #86 or #87 or #88 or #89

#91 MeSH descriptor: [Neoplasms by Histologic Type] explode all trees

#92 MeSH descriptor: [Neoplasms by Site] explode all trees

#93 neoplas*

#94 (tumor* or tumour*)

#95 (Krebs* or cancer*)

#96 malignan*

#97 (carcino* or karzino*)

#98 karzinom*

#99 sarcom*

#100 (leukem* or leukaem* or leucem*)

#101 lymphom*

#102 melano*

#103 metastas*

#104 (mesothelio* or mesotelio*)

#105 carcinomatos*

#106 (gliom* or glioblastom*)

#107 osteo*sarcom*

#108 (blastom* or neuroblastom*)

#109 #91 or #92 or #93 or #94 or #95 or #96 or #97 or #98 or #99 or #100 or #101 or #102 or #103 or #104 or #105 or #106 or #107 or #108

#110 #3 or #8 or #11 or #17 or #23 or #27 or #30 or #33 or #36 or #39 or #42 or #49 or #52 or #58 or #62 or #66

#111 #110 or #80

#112 #111 and #90 and #109 in Trials