Study ID

First author, year of publication

Type of study

Journal article or unpublished study

Clinical features and settings

• Presenting signs and symptoms

• Medical or surgical

• Age range for inclusion

• Intensive care unit, wards or emergency department

• Single or multi‐centre study

Participants

• Sample size (n)

• Country of study

• Age distribution

• Empirical antibiotics usage

Study design

• Retrospective or prospective design

• Sample (consecutive, random or unclear)

Reference standard

• Clinical diagnosis

• Culture ‐ blood, body fluid

• Culture and clinical diagnosis

• Interval between index test and reference standard

Index tests

• Name of assays

• Manufacturer

• Analyser/device

• Specimen type (venous/capillary; whole blood, serum or plasma)

• Specimen tube (for laboratory‐based assay)

• Cut‐off values

Target Condition

Sepsis spectrum ‐ sepsis, severe sepsis, septic shock

Data

• Number of true positives, false positives, true negatives, false negatives and undetermined/uninterpretable results

• Sensitivity and specificity of index test

• Missing results for index test

• Missing results for reference standard

Notes

Source of funding (whether any author is affiliated with the manufacturer of the index test; the study was directly funded by the manufacturer; study authors reported conflicts of interests related to the manufacturer or other funding sources)

Anything else of relevance