Appendix 1. MEDLINE (Ovid) search strategy

1. exp periodontal diseases/
2. periodont$.ti,ab.
3. (pyorrhoea or pyorrhea or pericementitis).ti,ab.
4. or/1‐3
5. exp Amoxicillin/
6. (actimoxi or amoclen or amolin or amopen or amopenixin or amox or amoxibiotic or amoxicilina or amoxicillin or amoxicilline or amoxicillinum or amoxil or amoxycillin or ampc or "apo amoxi" or augmentinxr or ax or clamoxyl or dispermox or efpenix or flemoxin or hiconcil or hydroxyampicillin or ibiamox or imacillin or larotid or moxacin or moxal or moxatag or ospamox or pamoxicillin or penamox or polymox or trimox or wymox or penicillin$).ti,ab.
7. exp Tetracyclines/
8. (adoxa or alodox or atridox or doryx or doxiciclina or doxy or doxycin or doxycyclin or doxycycline or doxycyclinum or doxylin or hydramycin or jenacyclin or microdox or monodox or morgidox or nicazeldoxykit or ocudox or oracea or periostat or supracyclin or "vibra tabs" or vibramycin or vibravenos).ti,ab.
9. (akamin or Akne‐Puren or aknemin or Aknin‐Mino or Aknosan or arestin or blemix or cyclomin or Cyclops or Dentomycin or dynacin or Icht‐Oral or klinomycin or lederderm or mestacine or minakne or Mino‐Wolff or minociclina or minociclinum or minocin or minoclir or minocyclin or minocycline or minocyclinum or minoderm or minolis or minomycin or minopen or minoplus or minotab or minox or minoz or mynocine or solodyn or vectrin or ximino).ti,ab.
10. (abramycin or achromycin or anhydrotetracycline or deschlorobiomycin or hostacyclin or liquamycin or sustamycin or tetrabid or tetracyclin or tetracycline or tetracyclinum or tetrazyklin or topicycline or tsiklomitsin).ti,ab.
11. Azithromycin/
12. (azadose or azasite or azenil or azibiot or azifast or azigram or azimakrol or azin or azithrocin or azithromycin or azithromycine or azithromycinum or azitromax or azitromicina or azitromin or aztrin or goxal or hemomycin or misultina or penalox or sumamed or toraseptol or ultreon or vinzam or zetnavion or zifin or zithromax or zitromax or zitrocin or zitrotek or zmax).ti,ab.
13. Clindamycin/
14. (chlolincocincleocin or chlorlincocin or cleocin or "clinda derm" or clindagel or clindamax or clindamicina or clindamycin or clindamycine or clindamycinum or clindesse or clindets or clinimycin or "dalacin c" or evoclin or zindaclin).ti,ab.
15. exp Fluoroquinolones/
16. (actira or avalox or avelox or izilox or moxeza or moxifloxacin or octegra or proflox or vigamox).ti,ab.
17. Metronidazole/
18. (acromona or anabact or arilin or clont or danizol or deflamon or efloran or elyzol or entizol or flagyl or fossyol or ginefalvir or klion or klont or metrolyl or metronidazol or metronidazole or metronidazolum or metrotop or nalox or nidagel or noritate or novonidazol or protostat or rosadan or satric or takimetol or trichazol$ or trichex or trichopol or "tricowas b" or trikacide or trikozol or trivazol or vandazole or vertisal or zadstat).ti,ab.
19. or/5‐18
20. 4 and 19

This search will be combined with the Cochrane Highly Sensitive Search Strategy (CHSSS) for identifying randomised trials in MEDLINE: sensitivity maximising version (2008 revision) as referenced in Chapter 6.4.11.1 and detailed in Box 6.4.c of the Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011) (Lefebvre 2011).

1. randomized controlled trial.pt.
2. controlled clinical trial.pt.
3. randomized.ab.
4. placebo.ab.
5. drug therapy.fs.
6. randomly.ab.
7. trial.ab.
8. groups.ab.
9. or/1‐8
10. exp animals/ not humans.sh.
11. 9 not 10