MEDLINE and CENTRAL search strategy (OVID platform)

1 exp Chancroid/
2 chanchroid$.tw.
3 chancroid$.tw.
4 (soft adj5 chancre).tw.
5 (ulcus adj5 molle).tw.
6 exp Haemophilus ducreyi/
7 ducrey$.tw.
8 (bacillus adj5 ulceris adj5 cancrosi):ab,ti
9 or/1‐8
10 exp Macrolides/
11 macrolide$.tw.
12 exp Erythromycin/
13 exp Erythromycin Estolate/
14 exp Erythromycin Ethylsuccinate/
15 exp Azithromycin/
16 exp Clarithromycin/
17 erythromycin.tw.
18 azithromycin.tw.
19 clarithromycin.tw.
20 or/10‐19
21 randomized controlled trial.pt.
22 controlled clinical trial.pt.
23 randomi?ed.ab.
24 placebo.ab.
25 clinical trials as topic.sh.
26 randomly.ab.
27 trial.ti.
28 or/21‐27
29 exp animals/ not humans.sh.
30 28 not 29
31 9 and 20 and 30

The CENTRAL strategy does not include the lines 21 to 30

Embase search strategy (Embase.com platform)

1 'ulcus molle'/exp

2 chanchroid*:ab,ti

3 chancroid*:ab,ti

4 (soft NEAR/5 chancre):ab,ti

5 (ulcus NEAR/5 molle):ab,ti

6 'Haemophilus ducreyi'/exp

7 ducrey*:ab,ti

8 (bacillus NEAR/5 ulceris NEAR/5 cancrosi):ab,ti

9 or/1‐8

10 'macrolide'/exp

11 macrolide*:ab,ti

12 'erythromycin'/exp

13 'erythromycin derivative'/exp

14 'erythromycin estolate'/exp

15 'erythromycin ethylsuccinate'/exp

16 'azithromycin'/exp

17 'clarithromycin'/exp

18 'clarithromycin derivative'/exp

19 erythromycin:ab,ti

20 azithromycin:ab,ti

21 clarithromycin:ab,ti

22 or/10‐21

23 'randomized controlled trial'/exp OR 'single blind procedure'/exp OR 'double blind procedure'/exp OR 'crossover

procedure'/exp OR random*:ab,ti OR placebo*:ab,ti OR allocat*:ab,ti OR crossover*:ab,ti OR 'cross over':ab,ti OR trial:ti OR

(doubl* NEXT/1 blind*):ab,ti NOT ('animal'/de OR 'animal experiment'/de OR 'nonhuman'/de NOT ('animal'/de OR 'animal

experiment'/de OR 'nonhuman'/de AND 'human'/de))

24 9 and 22 and 23 and [embase]/lim

LILACS (iAHx interface)

((mh:(chancroid) OR ti:(chancr*) OR ab:(chancr*) OR mh:(haemophilus ducreyi) OR ti:(ducrey*) OR ab:(ducrey*)) AND (mh:(macrolides) OR ti:(macrolides) OR ab:(macrolides) OR mh:(erythromycin) OR ti:(erythromycin) OR ab:(erythromycin) OR mh:(azithromycin) OR ti:(azithromycin) OR ab:(azithromycin) OR mh:(clarithromycin) OR ti:(clarithromycin) OR ab:(clarithromycin)) ) AND (instance:"regional") AND ( db:("LILACS"))

World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) portal

• macrolide* AND chancroid OR ducreyi

• erythromycin AND chancroid OR ducreyi

• azithromycin AND chancroid OR ducreyi

• clarithromycin AND chancroid OR ducreyi

ClinicalTrials.gov

chancroid OR ducreyi