We made the following changes to the protocol (Yu 2014).

1. In this review, we have specified 20% attrition as a criterion to make judgements about incomplete outcome data, which was not specified in the protocol.

2. We analysed data with a random‐effects model because we expected clinical and methodological heterogeneity between studies. Therefore, we deleted the planned sensitivity analysis using a random‐effects model and a fixed‐effect model separately for each outcome variable.

3. We performed subgroup analyses only for the primary outcomes, which was not specified in the protocol.

4. We did not find any quasi‐RCTs, therefore we did not conduct a sensitivity analysis based on these studies.

5. We did not perform survival analysis at 24 hours, 30 days and one year because there were no time‐to‐event data.

6. We did not find any cluster‐randomized controlled trials (cluster‐RCTs).

7. We did not create a funnel plot to qualitatively assess publication or reporting bias because fewer than 10 studies were included for each outcome.

8. We did not perform subgroup analysis according to age of participants because none of the included studies considered a paediatric population.

9. We generated a 'Summary of findings' table for the comparison 'Active cerebral oxygenation monitoring versus blinded cerebral oxygenation monitoring'. We also included adverse events in the 'Summary of findings' table (and adverse events as a secondary outcome in the review).