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Restricción o prohibición de la publicidad del alcohol para reducir el consumo de alcohol en adultos y adolescentes

Appendices

Appendix 1. PubMed search strategy

Search

Query

#22

Search (#20) NOT #21

#21

Search animals [mh] NOT humans [mh]

#20

Search ((#6) AND #10) AND #19

#19

Search (((((((#11) OR #12) OR #13) OR #14) OR #15) OR #16) OR #17) OR #18

#18

Search policy[tiab] OR policies[tiab]

#17

Search forbid*[tiab] OR prohibit*[tiab] OR interdict*[tiab] OR regulat*[tiab] OR reducing[tiab] OR reduce[tiab] OR reduced[tiab] OR reduction*[tiab] OR restrict*[tiab]

#16

Search ban[tiab] OR bans[tiab] OR banned[tiab] OR banning[tiab]

#15

Search limit*[tiab]

#14

Search law[tiab] OR laws[tiab]

#13

Search "Legislation as Topic"[MeSH]

#12

Search "Health Policy"[MeSH]

#11

Search "Policy"[MeSH]

#10

Search ((#7) OR #8) OR #9

#9

Search ((ad[tiab] OR ads[tiab] OR spot[tiab]) AND (Televis*[tiab] OR TV*[tiab] OR Radio[tiab] OR Radios[tiab] OR Movie*[tiab] OR Film*[tiab] OR Display*[tiab] OR media[tiab] OR Newspaper*[tiab] OR Magazine*[tiab] OR internet[tiab]))

#8

Search Advert*[tiab] OR Promot*[tiab] OR Sponsor*[tiab] OR Billboard*[tiab] OR Poster[tiab] OR Posters[tiab] OR branding[tiab] OR social marketing[mh] OR marketing[mh:noexp] OR marketing[tiab] OR commercial[tiab] OR commercials[tiab]

#7

Search "Advertising as Topic"[MeSH]

#6

Search ((((#1) OR #2) OR #3) OR #4) OR #5

#5

Search Wine*[tiab] OR Liquor*[tiab] OR Spirits[tiab] OR Beer*[tiab]

#4

Search (alcohol*[tiab] AND (drink*[tiab] OR beverage*[tiab] OR intoxicat*[tiab] OR abus*[tiab] OR misus*[tiab] OR risk*[tiab] OR consum*[tiab] OR excess*[tiab] OR problem*[tiab]))

#3

Search (drink*[tiab] AND (excess*[tiab] OR heavy[tiab] OR heavily[tiab] OR hazard*[tiab] OR binge[tiab] OR harmful[tiab] OR problem*[tiab]))

#2

Search "Alcohol Drinking"[MeSH]

#1

Search "Alcohol‐Related Disorders"[MeSH]

Appendix 2. EMBASE search strategy

No.

Query

Results

#1

alcohol abuse'/exp

20.128

#2

alcohol intoxication'/exp

11.57

#3

drinking behavior'/exp

32.649

#4

(drink* NEAR/3 (excess* OR heavy OR heavily OR hazard* OR binge OR harmful OR problem*)):ab,ti

15.566

#5

(alcohol* NEAR/3 (drink* OR beverage* OR intoxicat* OR abus* OR misus* OR risk* OR consum* OR excess* OR problem*)):ab,ti

82.144

#6

wine*:ab,ti OR liquor*:ab,ti OR spirits:ab,ti OR beer*:ab,ti

33.266

#7

#1 OR #2 OR #3 OR #4 OR #5 OR #6

148.236

#8

advertizing'/exp

15.076

#9

advert*:ab,ti OR promot*:ab,ti OR sponsor*:ab,ti OR billboard*:ab,ti OR poster:ab,ti OR posters:ab,ti OR branding:ab,ti OR marketing:ab,ti OR commercial:ab,ti OR commercials:ab,ti

800.025

#10

((ad OR ads OR spot) NEAR/5 (televis* OR tv OR radio OR radios OR movie* OR film* OR display* OR media OR newspaper* OR magazine* OR OR film* OR display* OR media OR newspaper* OR magazine* OR internet)):ab,ti

1.556

#11

social marketing'/exp

2.211

#12

marketing'/de

14.236

#13

#8 OR #9 OR #10 OR #11 OR #12

817.051

#14

policy'/exp OR policy:ab,ti OR policies:ab,ti

192.939

#15

law'/exp

79.431

#16

law:ab,ti OR laws:ab,ti

83.918

#17

limit*:ab,ti OR forbid*:ab,ti OR prohibit*:ab,ti OR interdict*:ab,ti OR regulat*:ab,ti OR reducing:ab,ti OR reduce:ab,ti OR reduced:ab,ti OR reduction*:ab,ti OR restrict*:ab,ti OR ban:ab,ti OR bans:ab,ti OR banned:ab,ti OR banning:ab,ti

4,530,066

#18

#14 OR #15 OR #16 OR #17

4,775,966

#19

#7 AND #13 AND #18

3.424

#20

#7 AND #13 AND #18 AND [humans]/lim AND [embase]/lim

1.569

Appendix 3. Cochrane Library search strategy

No.

Query

Results

#1

MeSH descriptor: [Alcohol‐Related Disorders] explode all trees

3159

#2

MeSH descriptor: [Alcohol Drinking] explode all trees

2082

#3

(drink* near (excess* or heavy or heavily or hazard* or binge or harmful or problem*)):ti,ab,kw (Word variations have been searched)

1034

#4

alcohol:ti,ab,kw (Word variations have been searched)

9402

#5

(Wine* or Liquor* or Spirits or Beer*):ti,ab,kw (Word variations have been searched)

867

#6

#1 or #2 or #3 or #4 or #5

10846

#7

MeSH descriptor: [Advertising as Topic] explode all trees

130

#8

MeSH descriptor: [Marketing] this term only

18

#9

(Advert* or Promot* or Sponsor* or Billboard* or Poster or Posters or branding or marketing or commercial or commercials):ti,ab,kw (Word variations have been searched)

18515

#10

((ad or ads or spot) near (Televis* or TV or Radio or Radios or Movie* or Film* or Display* or media or Newspaper* or Magazine* or internet)):ti,ab,kw (Word variations have been searched)

83

#11

#7 or #8 or #9 or #10

18572

#12

MeSH descriptor: [Policy] explode all trees

534

#13

MeSH descriptor: [Health Policy] explode all trees

417

#14

MeSH descriptor: [Legislation as Topic] explode all trees

607

#15

(law or laws):ti,ab,kw (Word variations have been searched)

576

#16

(limit* or ban or bans or banned or banning or forbid* or prohibit* or interdict* or regulat* or reducing or reduce or reduced or reduction* or restrict*):ti,ab,kw (Word variations have been searched)

176183

#17

(policy or policies):ti,ab,kw (Word variations have been searched)

3534

#18

#12 or #13 or #14 or #15 or #16 or #17

179102

#19

#6 and #11 and #18 in Trials

242

#20

#6 and #11 and #18 in Economic Evaluations

4

Appendix 4. PsycINFOsearch strategy

No.

Query

S20

S6 AND S10 AND S19

S19

S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18

S18

TI policy OR AB policy OR TI policies OR AB policies

S17

TI forbid* OR AB forbid* OR TI prohibit* OR AB prohibit* OR TI interdict* OR AB interdict* OR TI regulat* OR AB regulat* OR TI reducing OR AB reducing OR TI reduce OR AB reduce OR TI reduced OR AB reduced OR TI reduction* OR AB reduction OR TI restrict* OR AB restrict*

S16

TI ban OR AB ban OR TI bans OR AB bans OR TI banned OR AB banned OR TI banning OR AB banning

S15

TI limit* OR AB limit*

S14

TI law OR AB law OR TI laws OR AB laws

S13

SU Legislation as Topic

S12

SU Health Policy

S11

SU Policy

S10

S7 OR S8 OR S9

S9

(TI ad OR AB ad OR TI ads OR AB ads OR TI spot OR AB spot) AND (TI Televis* OR AB Televis* OR TI TV* OR AB TV OR TI Radio OR AB Radio OR TI Radios OR AB Radios OR TI Movie* OR AB Movie* OR TI Film* Or AB Film* OR TI Display* OR AB Display* OR TI media OR AB media OR TI Newspaper* OR AB Newspaper* OR TI Magazine* OR AB Magazine* OR TI internet OR AB Internet)

S8

TI Advert* OR AB Advert* OR TI Promot* OR AB Promot* OR TI Sponsor* OR AB Sponsor OR TI Billboard* OR AB Billboard OR TI Poster OR AB Poster OR TI Posters OR AB Posters OR TI branding OR AB branding OR MJ social marketing OR MJ marketing OR TI marketing OR AB marketing OR TI commercial OR AB commercial OR TI commercials OR AB commercials

S7

SU Advertising as Topic

S6

S1 OR S2 OR S3 OR S4 OR S5

S5

TI Wine* OR AB Wine* OR TI Liquor* OR AB Liquor OR TI Spirits OR AB Spirits OR TI Beer* OR AB Beer*

S4

(TI alcohol* OR AB alcohol*) AND (TI drink* OR AB drink* OR TI beverage* OR AB beverage* OR TI intoxicat* OR AB intoxicat* OR TI abus* OR AB abus OR TI misus* OR AB misus* OR TI risk* OR AB misus* OR TI consum* OR AB consum* OR TI excess* Or AB excess* OR TI problem* OR AB problem*)

S3

(TI drink* OR AB drink*) AND (TI excess* OR AB excess* OR TI heavy OR AB heavy OR TI heavily OR AB heavily OR TI hazard* OR AB hazard* OR TI binge OR AB binge OR TI harmful OR AB harmful OR TI problem* OR AB problem*)

S2

SU Alcohol Drinking

S1

SU Alcohol‐Related Disorders

Appendix 5. 'Risk of bias' criteria for RCTs, CCTs and prospective observational studies

Item

Low risk

High risk

Unclear risk

Sequence generation (Selection bias)

Investigators described a random component in the sequence generation process such as the use of random number table, coin tossing, cards or envelope shuffling

Investigators described a non‐random component in the sequence generation process such as the use of odd or even date of birth, algorithm based on the day/date of birth, hospital or clinic record number

Insufficient information to permit judgement of the sequence generation process

Allocation concealment (Selection bias)

Participants and the investigators enrolling participants cannot foresee assignment, e.g. central allocation; or sequentially numbered, opaque, sealed envelopes

Participants and investigators enrolling participants can foresee upcoming assignment, e.g. an open random allocation schedule (e.g. a list of random numbers); or envelopes were unsealed or non­opaque or not sequentially numbered

Insufficient information to permit judgement of the allocation concealment or the method not described

Blinding

of participants and providers (Performance bias)

Objective outcomes

No blinding or incomplete blinding, but the review authors judge that the outcome is not likely to be influenced by lack of blinding

Blinding of participants and key study personnel ensured, and unlikely that the blinding could have been broken

No blinding or incomplete blinding, and the outcome is likely to be influenced by lack of blinding

Blinding of key study participants and personnel attempted, but likely that the blinding could have been broken, and the outcome is likely to be influenced by lack of blinding

Insufficient information to permit judgement of low or high risk

Blinding

of participants and providers (Performance bias)

Subjective outcomes

Blinding of participants and providers and unlikely that the blinding could have been broken

No blinding or incomplete blinding, and the outcome is likely to be influenced by lack of blinding

Blinding of key study participants and personnel attempted, but likely that the blinding could have been broken, and the outcome is likely to be influenced by lack of blinding

Insufficient information to permit judgement of low or high risk

Blinding

of outcome assessor (Detection bias)

Objective outcomes

No blinding of outcome assessment, but the review authors judge that the outcome measurement is not likely to be influenced by lack of blinding

Blinding of outcome assessment ensured, and unlikely that the blinding could have been broken

No blinding of outcome assessment, and the outcome measurement is likely to be influenced by lack of blinding

Blinding of outcome assessment, but likely that the blinding could have been broken, and the outcome measurement is likely to be influenced by lack of blinding

Insufficient information to permit judgement of low or high risk

Blinding

of outcome assessor (Detection bias)

Subjective outcomes

No blinding of outcome assessment, but the review authors judge that the outcome measurement is not likely to be influenced by lack of blinding

Blinding of outcome assessment ensured, and unlikely that the blinding could have been broken

No blinding of outcome assessment, and the outcome measurement is likely to be influenced by lack of blinding

Blinding of outcome assessment, but likely that the blinding could have been broken, and the outcome measurement is likely to be influenced by lack of blinding

Insufficient information to permit judgement of low or high risk

Incomplete outcome data

No missing outcome data, reasons for missing outcome data unlikely to be related to true outcome, or missing outcome data balanced in number across groups

For dichotomous outcome data, the proportion of missing outcomes compared with observed event risk not enough to have a clinically relevant impact on the intervention effect estimate

For continuous outcome data, plausible effect size (difference in means or standardised difference in means) among missing outcomes not enough to have a clinically relevant impact on observed effect size

Missing data have been imputed using appropriate methods

All randomised patients are reported/analysed in the group they were allocated to by randomisation irrespective of non‐compliance and co‐interventions (intention to treat)

Reason for missing outcome data likely to be related to true outcome, with either imbalance in number across groups or reasons for missing data

For dichotomous outcome data, the proportion of missing outcomes compared with observed event risk enough to induce clinically relevant bias in intervention effect estimate

For continuous outcome data, plausible effect size (difference in means or standardised difference in means) among missing outcomes enough to induce clinically relevant bias in observed effect size

‘As‐treated’ analysis done with substantial departure of the intervention received from that assigned at randomisation

Insufficient reporting of attrition or exclusions (e.g. number randomised not stated, no reasons for missing data provided; number of drop out not reported for each group)

Selective reporting

A protocol is available which clearly states the primary outcome as the same as in the final trial report

The study protocol is not available but it is clear that the published reports include all expected outcomes, including those that were pre‐specified (convincing text of this nature may be uncommon)

The primary outcome differs between the protocol and final trial report

One or more reported primary outcomes were not pre‐specified (unless clear justification for their reporting is provided, such as an unexpected adverse effect)

One or more outcomes of interest in the review are reported incompletely so that they cannot be entered in a meta‐analysis

The study report fails to include results for a key outcome that would be expected to have been reported for such a study

No trial protocol is available or there is insufficient reporting to determine if selective reporting is present

Free of other bias:

Comparability of cohorts for baseline characteristics and outcome measures on the basis of the design or analysis

Exposed and non exposed individuals are matched in the design for most important confounding factors

Authors demonstrated balance between group for the confounders

Analysis are adjusted for most important confounding factors and imbalance

Randomised controlled trial

No matching or no adjustment for most important confounding factor

No information about comparability of cohort

Free of other bias: selection of the non‐exposed cohort

The sample has been drawn from the same community as the exposed cohort

Randomised controlled trial

The sample has been drawn from a different source

No description of the derivation of the non‐exposed cohort

Free of other bias: protection against contamination

Allocation was by community, institution or practice and it is unlikely that the control group received the intervention

Randomised controlled trial

It is likely that the control group received the intervention

It is possible that communication between intervention and control groups could have occurred

Ascertainment of exposure

Information in the study was obtained from a secure record (e.g. clinical records or structured interview)

Randomised controlled trial

Self report

No description

Appendix 6. 'Risk of bias' criteria for ITS studies

Item

Low risk

High risk

Unclear risk

Was the intervention independent of other changes?

Compelling arguments that the intervention occurred independently of other changes over time and the outcome was not influenced by other confounding variables/historic events during study period. If events/variables identified, note what they are

The intervention was not independent of other changes in time

Insufficient information to permit judgement of low or high risk

Was the shape of the intervention effect prespecified?

Point of analysis is the point of intervention OR a rational explanation for the shape of intervention effect was given by the author(s). Where appropriate, this should include an explanation if the point of analysis is NOT the point of intervention

It is clear that the shape of the intervention was not prespecified

Insufficient information to permit judgement of low or high risk

Was the intervention unlikely to affect data collection?

The intervention itself was unlikely to affect data collection (e.g. sources and methods of data collection were the same before and after the intervention)

The intervention itself was likely to affect data collection (e.g. any change in source or method of data collection reported)

Insufficient information to permit judgement of low or high risk

Was knowledge of the allocated interventions adequately prevented during the study?

The authors state explicitly that the primary outcome variables were assessed blindly, or the outcomes are objective, e.g. length of hospital stay. Primary outcomes are those variables that correspond to the primary hypothesis or question as defined by the authors

If the outcomes were not assessed blindly

Insufficient information to permit judgement of low or high risk

Were incomplete outcome data adequately addressed?

(If some primary outcomes were assessed blindly or affected by missing data and others were not, each primary outcome can be scored separately)

Missing outcome measures were unlikely to bias the results (e.g. the proportion of missing data was similar in the pre‐ and post‐intervention periods or the proportion of missing data was less than the effect size, i.e. unlikely to overturn the study result)

Missing outcome data were likely to bias the results. Do not assume 100% follow up unless stated explicitly)

Insufficient information to permit judgement of low or high risk

Was the study free from selective outcome reporting?

There is no evidence that outcomes were selectively reported (e.g. all relevant outcomes in the methods section are reported in the results section)

If some important outcomes are subsequently omitted from the results

Insufficient information to permit judgement of low or high risk

Was the study free from other risks of bias?

There is no evidence of other risks of bias, e.g. should consider if seasonality is an issue (i.e. if January to June comprises the pre‐intervention period and July to December the post, could the 'seasons' have caused a spurious effect)

There is evidence that other risks of bias exist, such as seasonality

Insufficient information to permit judgement of low or high risk

Appendix 7. May 2014 search: records retrieved per database

Database

No. of records retrieved

Potentially eligible

Included

Date searched

PubMed

432

0

0

2014‐05‐28

EMBASE

319

0

0

2014‐05‐27

CENTRAL

55

0

0

2014‐05‐28

NHS Economic Evaluations Database

0

0

0

2014‐05‐28

Cochrane Drug and Alcohol Specialised Register

0

0

0

2014‐05‐28

Appendix 8. Results of searches of economic and marketing databases

Database

URL

Search term

No. of records retrieved

Potentially eligible

Included

Date searched

AgEcon

ageconsearch.umn.edu/

alcohol

154

1

0

2013‐10‐16

Business Source Premier

EBSCOHost

alcohol advertising

654

16

0

2013‐10‐18

ETOH databases on the National Institute of Health Alcohol and Alcohol Problems database (1972 to 2003)

http://etoh.niaaa.nih.gov/

ban; restriction

29; 134

0;1

0;0

2013‐10‐22

The Chartered Institute of Marketing (UK‐based)

http://library.cim.co.uk/ics‐wpd/exec/icswppro.dll

alcohol

237

3

0 (2 reviews)

2013‐10‐22

Association for Consumer Research

http://www.acrwebsite.org/search/search‐conference‐proceedings.aspx

alcohol

560

3

0

2013‐10‐22

Appendix 9. Results of conferences and manual report archives searched

Conference

URL

Search term

No. of records retrieved

Potentially eligible

Included

Date searched

International Health Economics Association

www.ssrn.com

alcohol

699

20

0

2013‐06‐03

Research Society on Alcoholism

www.rsoa.org

No proceedings published. Oral and poster presentations are published in the journal, Alcoholism: Clinical and Experimental Research and should therefore have been identified in the journal database searches

International Society for Biomedical Research in Alcoholism

www.isbra.com/

We were not able to obtain access to this and no response to email requests was received

Kettil Bruun Society

http://www.kettilbruun.org

The contact person responded that the Society is in the process of archiving conference papers and there is no means to search electronically at the current time. The 2013 symposium was manually searched

2013‐10‐21

39th Annual Alcohol Epidemiology Symposium of the Kettil Bruun Society, Kampala, Uganda, 3 ‐ 7 June, 2013

Manual search of conference abstract book

143

2

0

2013‐10‐24

International Network on Brief Interventions for Alcohol Problems (INEBRIA)

http://www.inebria.net/Du14/html/en/dir1338/index.html

INEBRIA contact person responded that INEBRIA conferences do not cover alcohol advertising

2013‐10‐22

Vietnam Alcohol Policy Workshop 2009

http://www.icap.org/

Manual handsearch

0

0

0

2013‐10‐18

ICAP Africa Region Conference 2008

http://www.icap.org/

Manual handsearch

0

0

0

2013‐10‐18

ICAP Asia‐Pacific Alcohol Forum 2008

http://www.icap.org/

Manual handsearch

0

0

0

2013‐10‐18

The Foundation for Alcohol research

http://www.abmrf.org/meetings_conferences.asp

The Foundation supports the Research Society on Alcoholism. No proceedings published. Oral and poster presentations are published in the journal, Alcoholism: Clinical and Experimental Research and should therefore have been identified in the journal database searches. See above under Research Society on Alcoholism

European Advertising Standards Alliance

http://www.easa‐alliance.org/

EASA does not have a database of meeting abstracts but provided relevant articles and papers for consideration

Flow diagram of screening and eligibility of records of electronic databases: PubMed, EMBASE, The Cochrane Library (CENTRAL and UK National Health Service Economic Evaluations Database) and PsychINFO
Figuras y tablas -
Figure 1

Flow diagram of screening and eligibility of records of electronic databases: PubMed, EMBASE, The Cochrane Library (CENTRAL and UK National Health Service Economic Evaluations Database) and PsychINFO

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies (N = 4).
Figuras y tablas -
Figure 2

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies (N = 4).

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study (N = 4).
Figuras y tablas -
Figure 3

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study (N = 4).

Comparison 1 Low‐alcohol content movies versus high‐alcohol content movies, Outcome 1 Total alcohol consumption in number of glasses.
Figuras y tablas -
Analysis 1.1

Comparison 1 Low‐alcohol content movies versus high‐alcohol content movies, Outcome 1 Total alcohol consumption in number of glasses.

Comparison 2 Non‐alcohol commercials versus alcohol commercials, Outcome 1 Total alcohol consumption in number of glasses.
Figuras y tablas -
Analysis 2.1

Comparison 2 Non‐alcohol commercials versus alcohol commercials, Outcome 1 Total alcohol consumption in number of glasses.

Comparison 3 High‐alcohol content movies versus low‐alcohol content movies adjusted for clustering effects, Outcome 1 Total alcohol consumption.
Figuras y tablas -
Analysis 3.1

Comparison 3 High‐alcohol content movies versus low‐alcohol content movies adjusted for clustering effects, Outcome 1 Total alcohol consumption.

Comparison 4 Alcohol commercials versus non‐alcohol commercials adjusted for clustering effects, Outcome 1 Total alcohol consumption.
Figuras y tablas -
Analysis 4.1

Comparison 4 Alcohol commercials versus non‐alcohol commercials adjusted for clustering effects, Outcome 1 Total alcohol consumption.

Comparison 5 Total advertising ban versus Partial advertising ban Abrupt permanent model, Outcome 1 Volume of alcohol (beer, wine and spirits) sales in kilolitres.
Figuras y tablas -
Analysis 5.1

Comparison 5 Total advertising ban versus Partial advertising ban Abrupt permanent model, Outcome 1 Volume of alcohol (beer, wine and spirits) sales in kilolitres.

Comparison 5 Total advertising ban versus Partial advertising ban Abrupt permanent model, Outcome 2 Volume of beer sales in kilolitres.
Figuras y tablas -
Analysis 5.2

Comparison 5 Total advertising ban versus Partial advertising ban Abrupt permanent model, Outcome 2 Volume of beer sales in kilolitres.

Comparison 5 Total advertising ban versus Partial advertising ban Abrupt permanent model, Outcome 3 Volume of wine sales in kilolitres.
Figuras y tablas -
Analysis 5.3

Comparison 5 Total advertising ban versus Partial advertising ban Abrupt permanent model, Outcome 3 Volume of wine sales in kilolitres.

Comparison 5 Total advertising ban versus Partial advertising ban Abrupt permanent model, Outcome 4 Volume of spirits sales in kilolitres.
Figuras y tablas -
Analysis 5.4

Comparison 5 Total advertising ban versus Partial advertising ban Abrupt permanent model, Outcome 4 Volume of spirits sales in kilolitres.

Comparison 6 Total advertising ban versus Partial advertising ban Gradual permanent model, Outcome 1 Volume of alcohol (beer, wine and spirits) sales in kilolitres.
Figuras y tablas -
Analysis 6.1

Comparison 6 Total advertising ban versus Partial advertising ban Gradual permanent model, Outcome 1 Volume of alcohol (beer, wine and spirits) sales in kilolitres.

Comparison 6 Total advertising ban versus Partial advertising ban Gradual permanent model, Outcome 2 Volume of beer sales in kilolitres.
Figuras y tablas -
Analysis 6.2

Comparison 6 Total advertising ban versus Partial advertising ban Gradual permanent model, Outcome 2 Volume of beer sales in kilolitres.

Comparison 6 Total advertising ban versus Partial advertising ban Gradual permanent model, Outcome 3 Volume of wine sales in kilolitres.
Figuras y tablas -
Analysis 6.3

Comparison 6 Total advertising ban versus Partial advertising ban Gradual permanent model, Outcome 3 Volume of wine sales in kilolitres.

Comparison 6 Total advertising ban versus Partial advertising ban Gradual permanent model, Outcome 4 Volume of spirits sales in kilolitres.
Figuras y tablas -
Analysis 6.4

Comparison 6 Total advertising ban versus Partial advertising ban Gradual permanent model, Outcome 4 Volume of spirits sales in kilolitres.

Comparison 7 Alcohol ban versus no ban, Outcome 1 % Change in beer consumption.
Figuras y tablas -
Analysis 7.1

Comparison 7 Alcohol ban versus no ban, Outcome 1 % Change in beer consumption.

Summary of findings for the main comparison. Non‐alcohol commercials compared to alcohol commercials for reduction of alcohol consumption

Non‐alcohol commercials compared to alcohol commercials for reduction of alcohol consumption

Patient or population: General population
Settings: General population
Intervention: Non‐alcohol commercials
Comparison: Alcohol commercials

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No. of participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

Alcohol commercials

Non‐alcohol commercials

Total alcohol consumption in number of glasses
Follow up: mean 1.5 hours

The mean total alcohol consumption in number of glasses in the intervention groups was
0.73 less
(1.3 to 0.16 less)

80
(1 study)

⊕⊝⊝⊝
very low1,2,3

Delayed age of initiation of alcohol use ‐ not measured

Not estimable

This outcome was not applicable in this trial

Reduction in rate of reported risk behaviour ‐ not measured

Not estimable

Reduction in alcohol‐related injuries or accidents ‐ not measured

Not estimable

Reduction in individual spending on alcohol ‐ not measured

Not estimable

Loss of revenue from alcohol industry ‐ not measured

Not estimable

This outcome was not applicable in this trial

Loss of advertising revenue ‐ not measured

Not estimable

This outcome was not applicable in this trial

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval;

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 Risk of bias: rated as serious. In the Engels 2009 trial, randomisation was inadequate (the groups differed on the baseline prognostic factor prior drinking levels), allocation concealment was unclear and the researchers were not blinded to group allocation so detection bias may be present.
2 Indirectness: rated as serious. The trial is specific to young men from a university setting in a high‐income country and may not be generalisable to other settings.
3 Imprecision: rated as serious: The 95% CI is wide and the sample size small.

Figuras y tablas -
Summary of findings for the main comparison. Non‐alcohol commercials compared to alcohol commercials for reduction of alcohol consumption
Summary of findings 2. Alcohol ban compared to no ban for the general population

Alcohol ban compared to no ban for the general population

Patient or population: General population
Settings: General population
Intervention: Alcohol ban
Comparison: No ban

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No. of pParticipants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

No ban

Alcohol ban

Alcohol consumption: % change in beer consumption
Follow up: 1.2 to 3 years

The mean % change in beer consumption in the intervention groups was
1.1 more
(5.26 less to 7.47 more)

2 ITS studies

⊕⊝⊝⊝
very low1,2

Results for consumption of other types of alcoholic beverages and total consumption were inconsistent in the three ITS studies

Reduction in rate of reported risk behaviour ‐ not reported

See comment

See comment

Not estimable

See comment

None of the studies measured this outcome

Delayed age of initiation of alcohol use ‐ not reported

See comment

See comment

Not estimable

See comment

None of the studies measured this outcome

Reduction in alcohol‐related injuries or accidents ‐ not reported

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Not estimable

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None of the studies measured this outcome

Reduction in individual spending on alcohol ‐ not reported

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Not estimable

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None of the studies measured this outcome

Loss of revenue from alcohol industry ‐ not reported

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Not estimable

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None of the studies measured this outcome

Loss of advertising revenue ‐ not reported

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Not estimable

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None of the studies measured this outcome

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval; ITS: interrupted time series

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 Risk of bias: rated as serious: the risk of a dilution effect is present in both studies (Ogborne 1980 and Smart 1976) and seasonality may not be adequately addressed in the analyses. The studies were not further downgraded for limitations in causal inference due to a lack of randomisation, as the initial GRADE rating commenced at low quality.
2 Inconsistency: rated as serious. The results from the Smart 1976 study indicate a reduction in beer consumption after implementing a ban on advertising and Ogborne 1980 shows an increase in beer consumption.

Figuras y tablas -
Summary of findings 2. Alcohol ban compared to no ban for the general population
Comparison 1. Low‐alcohol content movies versus high‐alcohol content movies

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Total alcohol consumption in number of glasses Show forest plot

1

80

Mean Difference (IV, Fixed, 95% CI)

‐0.65 [‐1.23, ‐0.07]

Figuras y tablas -
Comparison 1. Low‐alcohol content movies versus high‐alcohol content movies
Comparison 2. Non‐alcohol commercials versus alcohol commercials

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Total alcohol consumption in number of glasses Show forest plot

1

80

Mean Difference (IV, Fixed, 95% CI)

‐0.73 [‐1.30, ‐0.16]

Figuras y tablas -
Comparison 2. Non‐alcohol commercials versus alcohol commercials
Comparison 3. High‐alcohol content movies versus low‐alcohol content movies adjusted for clustering effects

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Total alcohol consumption Show forest plot

1

Coefficient (Fixed, 95% CI)

0.74 [0.05, 1.43]

Figuras y tablas -
Comparison 3. High‐alcohol content movies versus low‐alcohol content movies adjusted for clustering effects
Comparison 4. Alcohol commercials versus non‐alcohol commercials adjusted for clustering effects

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Total alcohol consumption Show forest plot

1

Coefficient (Fixed, 95% CI)

0.83 [0.14, 1.52]

Figuras y tablas -
Comparison 4. Alcohol commercials versus non‐alcohol commercials adjusted for clustering effects
Comparison 5. Total advertising ban versus Partial advertising ban Abrupt permanent model

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Volume of alcohol (beer, wine and spirits) sales in kilolitres Show forest plot

1

Mean Difference (Fixed, 95% CI)

‐11.11 [‐27.56, 5.34]

2 Volume of beer sales in kilolitres Show forest plot

1

Mean Difference (Fixed, 95% CI)

14.89 [0.39, 29.39]

3 Volume of wine sales in kilolitres Show forest plot

1

Mean Difference (Fixed, 95% CI)

1.15 [‐0.91, 3.21]

4 Volume of spirits sales in kilolitres Show forest plot

1

Mean Difference (Fixed, 95% CI)

‐22.49 [‐36.83, ‐8.15]

Figuras y tablas -
Comparison 5. Total advertising ban versus Partial advertising ban Abrupt permanent model
Comparison 6. Total advertising ban versus Partial advertising ban Gradual permanent model

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Volume of alcohol (beer, wine and spirits) sales in kilolitres Show forest plot

1

Mean Difference (Fixed, 95% CI)

‐11.96 [‐55.42, 31.50]

2 Volume of beer sales in kilolitres Show forest plot

1

Mean Difference (Fixed, 95% CI)

‐0.54 [‐1.57, 0.49]

3 Volume of wine sales in kilolitres Show forest plot

1

Mean Difference (Fixed, 95% CI)

‐0.00 [‐0.04, 0.04]

4 Volume of spirits sales in kilolitres Show forest plot

1

Mean Difference (Fixed, 95% CI)

‐27.8 [‐59.34, 3.74]

Figuras y tablas -
Comparison 6. Total advertising ban versus Partial advertising ban Gradual permanent model
Comparison 7. Alcohol ban versus no ban

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 % Change in beer consumption Show forest plot

2

Mean % change (Random, 95% CI)

1.10 [‐5.26, 7.47]

Figuras y tablas -
Comparison 7. Alcohol ban versus no ban