We are grateful to:

• James M Wright and the Cochrane Hypertension Group, for their encouragement, support, and assistance;

• Lourdes Muruzábal, María del Mar Malón, Rodolfo Montoya, and Antonio López, for their relevant contributions as authors to a previous version of this systematic review;

• the Biomedical Information Center of Navarre, which provided most of the published documents reviewed in this report (Stephen Adams, Vancouver, Canada, provided assistance with some references that were especially difficult to find);

• Miguel Ángel Imízcoz, cardiologist, who provided specific advice related to ascertainment of cardiovascular events from individual patient data;

• Agustín Ciapponi and Demian Glujovsky, of the Institute of Clinical Effectiveness and Health Policy (IECS), Buenos Aires, Argentina, who provided access to Early Review Organizing Software;

• Annalisa Perna, Giuseppe Remuzzi, and Piero Ruggenenti, of Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy, who provided individual patient data for REIN‐2 2005;

• Kate Fletcher, of the University of Birmingham, Birmingham, UK, and Jonathan Mant, of the University of Cambridge, Cambridge, UK, who provided individual patient data for Past BP 2016; and

• Larrye Loss and Julie Ye, from AstraZeneca, Wilmington (DE), USA, who provided access to protocol, forms, Clinical Study Report, and individual patient data for the HOT 1998 study. This manuscript was not prepared in collaboration with AstraZeneca staff and does not necessarily reflect the opinions or views of the company. According to the Data Transfer Agreement, AstraZeneca was entitled to make comments to the final report but approval was given with no remarks;

Data from SPS3 2013 were supplied by the National Institute of Neurological Disorders and Stroke (NINDS). This manuscript does not necessarily reflect the opinions or views of the SPS3 study, the NINDS Central Repositories, or the NINDS.

AASK 2002 and MDRD 1994 were conducted by the AASK/MDRD Investigators and supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Data from the AASK 2002 and MDRD 1994 studies reported here were supplied by the NIDDK Central Repositories. This manuscript was not prepared in collaboration with investigators in the AASK 2002 and MDRD 1994 studies and does not necessarily reflect the opinions or views of the AASK/MDRD studies, the NIDDK Central Repositories, or the NIDDK.

This manuscript was prepared with ACCORD and SPRINT_POP Research Materials obtained from the NHLBI Biologic Specimen and Data Repository Information Coordination Center and does not necessarily reflect the opinions or views of ACCORD, SPRINT_POP, or the National Heart, Lung and Blood Institute (NHLBI).