Hábito dietético "mediterráneo" para la prevención primaria de las enfermedades cardiovasculares
Información
- DOI:
- https://doi.org/10.1002/14651858.CD009825.pub2Copiar DOI
- Base de datos:
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- Cochrane Database of Systematic Reviews
- Versión publicada:
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- 12 agosto 2013see what's new
- Tipo:
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- Intervention
- Etapa:
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- Review
- Grupo Editorial Cochrane:
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Grupo Cochrane de Corazón
- Copyright:
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- Copyright © 2014 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Cifras del artículo
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Citado por:
Autores
Contributions of authors
All authors contributed to the protocol development. Karen Rees, Louise Hartley and Nadine Flowers screened titles and abstracts, assessed studies for formal inclusion and exclusion, abstracted data and assessed risk of bias of included studies. Karen Rees analysed data and drafted the methods and results sections, Saverio Stranges drafted the background and discussion. All authors commented on later drafts of the review.
Sources of support
Internal sources
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Warwick Medical School, University of Warwick, UK.
External sources
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NIHR Cochrane Programme Grant, UK.
Declarations of interest
None known.
Acknowledgements
We would like to acknowledge the trial search coordinators Nicole Martin and Jo Abbot for constructing and running searches for this review. We would also like to acknowledge Lina Mattsson for translating one paper written in Norwegian, and William Tigbe for translating one paper written in Polish.
Version history
| Published | Title | Stage | Authors | Version |
| 2019 Mar 13 | Mediterranean‐style diet for the primary and secondary prevention of cardiovascular disease | Review | Karen Rees, Andrea Takeda, Nicole Martin, Leila Ellis, Dilini Wijesekara, Abhinav Vepa, Archik Das, Louise Hartley, Saverio Stranges | |
| 2013 Aug 12 | 'Mediterranean' dietary pattern for the primary prevention of cardiovascular disease | Review | Karen Rees, Louise Hartley, Nadine Flowers, Aileen Clarke, Lee Hooper, Margaret Thorogood, Saverio Stranges | |
| 2012 Apr 18 | 'Mediterranean' dietary pattern for the primary prevention of cardiovascular disease | Protocol | Karen Rees, Louise Hartley, Aileen Clarke, Margaret Thorogood, Saverio Stranges | |
Differences between protocol and review
We intended to look at studies examining dietary advice to follow a Mediterranean‐style diet separately from studies examining the provision of foods, but for all studies that met our inclusion criteria the intervention was dietary advice. It was also our intention to stratify results according to the number of components constituting the Mediterranean dietary pattern and the intensity and duration of the intervention. However, there were insufficient trials that met the inclusion criteria to perform these analyses. Similarly, we planned to stratify results by general population and high‐risk participants, follow‐up period, age and gender to determine their impact on effect estimates but there are insufficient trials to date to do this.
We also intended to examine the effect of alcohol consumption and other potential adverse effects of the Mediterranean diet in our analyses but this information was not reported in the few trials that met the inclusion criteria.
In the protocol, we stated that we would exclude studies where loss to follow‐up exceeded 20%. We have relaxed this inclusion criterion and have instead performed sensitivity analyses excluding these studies to examine the impact on pooled effect estimates.
We also intended to focus on studies with follow‐up of six months or more but studies with this length of follow‐up were lacking and so studies with follow‐up of three months or more were included.
Keywords
MeSH
Medical Subject Headings (MeSH) Keywords
Medical Subject Headings Check Words
Adult; Humans;
PICO
Study flow diagram.
Comparison 1 Mediterranean dietary intervention versus no intervention or minimal intervention (secondary outcomes ‐ CVD risk factors), Outcome 1 Total cholesterol (mmol/L), change from baseline.
Comparison 1 Mediterranean dietary intervention versus no intervention or minimal intervention (secondary outcomes ‐ CVD risk factors), Outcome 2 Total cholesterol (mmol/L), change from baseline, subgroup analysis.
Comparison 1 Mediterranean dietary intervention versus no intervention or minimal intervention (secondary outcomes ‐ CVD risk factors), Outcome 3 LDL‐cholesterol (mmol/L), change from baseline.
Comparison 1 Mediterranean dietary intervention versus no intervention or minimal intervention (secondary outcomes ‐ CVD risk factors), Outcome 4 LDL‐cholesterol (mmol/L), change from baseline, subgroup analysis.
Comparison 1 Mediterranean dietary intervention versus no intervention or minimal intervention (secondary outcomes ‐ CVD risk factors), Outcome 5 HDL‐cholesterol (mmol/L), change from baseline.
Comparison 1 Mediterranean dietary intervention versus no intervention or minimal intervention (secondary outcomes ‐ CVD risk factors), Outcome 6 Triglycerides (mmol/L), change from baseline.
Comparison 1 Mediterranean dietary intervention versus no intervention or minimal intervention (secondary outcomes ‐ CVD risk factors), Outcome 7 Systolic blood pressure (mmHg), change from baseline.
Comparison 1 Mediterranean dietary intervention versus no intervention or minimal intervention (secondary outcomes ‐ CVD risk factors), Outcome 8 Diastolic blood pressure (mmHg), change from baseline.
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Total cholesterol (mmol/L), change from baseline Show forest plot | 8 | 4151 | Mean Difference (IV, Random, 95% CI) | ‐0.16 [‐0.26, ‐0.06] |
| 2 Total cholesterol (mmol/L), change from baseline, subgroup analysis Show forest plot | 8 | 3815 | Mean Difference (IV, Fixed, 95% CI) | ‐0.20 [‐0.23, ‐0.17] |
| 2.1 Interventions described as Mediterranean diet (or comprise both increased fruit and vegetables and monounsaturated fatty acids) | 4 | 436 | Mean Difference (IV, Fixed, 95% CI) | ‐0.23 [‐0.27, ‐0.20] |
| 2.2 Interventions with 2 components but not described as Mediterranean diet or comprising both increased fruit and vegetables and monounsaturated fatty acids | 4 | 3379 | Mean Difference (IV, Fixed, 95% CI) | ‐0.06 [‐0.13, 0.01] |
| 3 LDL‐cholesterol (mmol/L), change from baseline Show forest plot | 6 | 3227 | Mean Difference (IV, Fixed, 95% CI) | ‐0.07 [‐0.13, ‐0.01] |
| 4 LDL‐cholesterol (mmol/L), change from baseline, subgroup analysis Show forest plot | 6 | 3227 | Mean Difference (IV, Random, 95% CI) | ‐0.07 [‐0.17, 0.03] |
| 4.1 Interventions described as Mediterranean diet (or comprise both increased fruit and vegetables and monounsaturated fatty acids) | 3 | 252 | Mean Difference (IV, Random, 95% CI) | ‐0.16 [‐0.39, 0.07] |
| 4.2 Interventions with 2 components but not described as the Mediterranean diet or comprising both increased F&V and MUFAs | 3 | 2975 | Mean Difference (IV, Random, 95% CI) | ‐0.06 [‐0.12, 0.00] |
| 5 HDL‐cholesterol (mmol/L), change from baseline Show forest plot | 7 | Mean Difference (IV, Fixed, 95% CI) | Totals not selected | |
| 6 Triglycerides (mmol/L), change from baseline Show forest plot | 6 | Mean Difference (IV, Fixed, 95% CI) | Totals not selected | |
| 7 Systolic blood pressure (mmHg), change from baseline Show forest plot | 5 | Mean Difference (IV, Fixed, 95% CI) | Totals not selected | |
| 8 Diastolic blood pressure (mmHg), change from baseline Show forest plot | 5 | Mean Difference (IV, Fixed, 95% CI) | Totals not selected | |
