Scolaris Content Display Scolaris Content Display

Intervention and context logic model.
Figuras y tablas -
Figure 1

Intervention and context logic model.

Generalisability logic model.
Figuras y tablas -
Figure 2

Generalisability logic model.

Study flow diagram.
Figuras y tablas -
Figure 3

Study flow diagram.

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 4

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Figuras y tablas -
Figure 5

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Comparison 1 Safer or reduced sexual activity, Outcome 1 Number of times had sex ‐ 3 months.
Figuras y tablas -
Analysis 1.1

Comparison 1 Safer or reduced sexual activity, Outcome 1 Number of times had sex ‐ 3 months.

Comparison 1 Safer or reduced sexual activity, Outcome 2 Number of times had sex ‐ 6 months.
Figuras y tablas -
Analysis 1.2

Comparison 1 Safer or reduced sexual activity, Outcome 2 Number of times had sex ‐ 6 months.

Comparison 1 Safer or reduced sexual activity, Outcome 3 Number of sexual partners ‐ 3 months.
Figuras y tablas -
Analysis 1.3

Comparison 1 Safer or reduced sexual activity, Outcome 3 Number of sexual partners ‐ 3 months.

Comparison 1 Safer or reduced sexual activity, Outcome 4 Number of sexual partners ‐ 6 months.
Figuras y tablas -
Analysis 1.4

Comparison 1 Safer or reduced sexual activity, Outcome 4 Number of sexual partners ‐ 6 months.

Comparison 2 Safer or reduced substance use, Outcome 1 Number of days used alcohol in last month ‐ 1 month.
Figuras y tablas -
Analysis 2.1

Comparison 2 Safer or reduced substance use, Outcome 1 Number of days used alcohol in last month ‐ 1 month.

Comparison 2 Safer or reduced substance use, Outcome 2 Number of days used alcohol in last month ‐ 3 months.
Figuras y tablas -
Analysis 2.2

Comparison 2 Safer or reduced substance use, Outcome 2 Number of days used alcohol in last month ‐ 3 months.

Comparison 2 Safer or reduced substance use, Outcome 3 Percent days of alcohol use in last 90 days (Form 90) ‐ 3 months.
Figuras y tablas -
Analysis 2.3

Comparison 2 Safer or reduced substance use, Outcome 3 Percent days of alcohol use in last 90 days (Form 90) ‐ 3 months.

Comparison 2 Safer or reduced substance use, Outcome 4 Percent days of alcohol use in last 90 days (Form 90) ‐ 6 months.
Figuras y tablas -
Analysis 2.4

Comparison 2 Safer or reduced substance use, Outcome 4 Percent days of alcohol use in last 90 days (Form 90) ‐ 6 months.

Comparison 2 Safer or reduced substance use, Outcome 5 Percent days of alcohol use in last 90 days (Form 90) ‐ 12 months.
Figuras y tablas -
Analysis 2.5

Comparison 2 Safer or reduced substance use, Outcome 5 Percent days of alcohol use in last 90 days (Form 90) ‐ 12 months.

Comparison 2 Safer or reduced substance use, Outcome 6 Number of standard drinks (Form 90) ‐ 3 months.
Figuras y tablas -
Analysis 2.6

Comparison 2 Safer or reduced substance use, Outcome 6 Number of standard drinks (Form 90) ‐ 3 months.

Comparison 2 Safer or reduced substance use, Outcome 7 Adolescent Drinking Index ‐ 3 months.
Figuras y tablas -
Analysis 2.7

Comparison 2 Safer or reduced substance use, Outcome 7 Adolescent Drinking Index ‐ 3 months.

Comparison 2 Safer or reduced substance use, Outcome 8 Percent days of alcohol/drug use (excl tobacco) (Form 90) ‐ 3 months.
Figuras y tablas -
Analysis 2.8

Comparison 2 Safer or reduced substance use, Outcome 8 Percent days of alcohol/drug use (excl tobacco) (Form 90) ‐ 3 months.

Comparison 2 Safer or reduced substance use, Outcome 9 Percent days of alcohol/drug use (excl tobacco) (Form 90) ‐ 6 months.
Figuras y tablas -
Analysis 2.9

Comparison 2 Safer or reduced substance use, Outcome 9 Percent days of alcohol/drug use (excl tobacco) (Form 90) ‐ 6 months.

Comparison 2 Safer or reduced substance use, Outcome 10 Percent days of alcohol/drug use (excl tobacco) (Form 90) ‐ 12 months.
Figuras y tablas -
Analysis 2.10

Comparison 2 Safer or reduced substance use, Outcome 10 Percent days of alcohol/drug use (excl tobacco) (Form 90) ‐ 12 months.

Comparison 2 Safer or reduced substance use, Outcome 11 Percent days only/any drug use (Form 90) ‐ 3 months.
Figuras y tablas -
Analysis 2.11

Comparison 2 Safer or reduced substance use, Outcome 11 Percent days only/any drug use (Form 90) ‐ 3 months.

Comparison 2 Safer or reduced substance use, Outcome 12 Percent days only/any drug use (Form 90) ‐ 6 months.
Figuras y tablas -
Analysis 2.12

Comparison 2 Safer or reduced substance use, Outcome 12 Percent days only/any drug use (Form 90) ‐ 6 months.

Comparison 2 Safer or reduced substance use, Outcome 13 Percent days only/any drug use (Form 90) ‐ 12 months.
Figuras y tablas -
Analysis 2.13

Comparison 2 Safer or reduced substance use, Outcome 13 Percent days only/any drug use (Form 90) ‐ 12 months.

Comparison 2 Safer or reduced substance use, Outcome 14 Number of days used marijuana in last month ‐ 1 month.
Figuras y tablas -
Analysis 2.14

Comparison 2 Safer or reduced substance use, Outcome 14 Number of days used marijuana in last month ‐ 1 month.

Comparison 2 Safer or reduced substance use, Outcome 15 Number of days used marijuana in last month ‐ 3 months.
Figuras y tablas -
Analysis 2.15

Comparison 2 Safer or reduced substance use, Outcome 15 Number of days used marijuana in last month ‐ 3 months.

Comparison 2 Safer or reduced substance use, Outcome 16 Number of days used other drugs in last month ‐ 1 month.
Figuras y tablas -
Analysis 2.16

Comparison 2 Safer or reduced substance use, Outcome 16 Number of days used other drugs in last month ‐ 1 month.

Comparison 2 Safer or reduced substance use, Outcome 17 Number of days used other drugs in last month ‐ 3 months.
Figuras y tablas -
Analysis 2.17

Comparison 2 Safer or reduced substance use, Outcome 17 Number of days used other drugs in last month ‐ 3 months.

Comparison 2 Safer or reduced substance use, Outcome 18 Number of problem consequences ‐ 3 months.
Figuras y tablas -
Analysis 2.18

Comparison 2 Safer or reduced substance use, Outcome 18 Number of problem consequences ‐ 3 months.

Comparison 2 Safer or reduced substance use, Outcome 19 Number of problem consequences ‐ 6 months.
Figuras y tablas -
Analysis 2.19

Comparison 2 Safer or reduced substance use, Outcome 19 Number of problem consequences ‐ 6 months.

Comparison 2 Safer or reduced substance use, Outcome 20 Number of substance use diagnoses (CDISC) ‐ 3 months.
Figuras y tablas -
Analysis 2.20

Comparison 2 Safer or reduced substance use, Outcome 20 Number of substance use diagnoses (CDISC) ‐ 3 months.

Comparison 2 Safer or reduced substance use, Outcome 21 Number of categories of drug use (Form 90) ‐ 6 months.
Figuras y tablas -
Analysis 2.21

Comparison 2 Safer or reduced substance use, Outcome 21 Number of categories of drug use (Form 90) ‐ 6 months.

Comparison 3 Self esteem, Outcome 1 Self esteem at endpoint.
Figuras y tablas -
Analysis 3.1

Comparison 3 Self esteem, Outcome 1 Self esteem at endpoint.

Comparison 4 Depression, Outcome 1 Depression at 3 months.
Figuras y tablas -
Analysis 4.1

Comparison 4 Depression, Outcome 1 Depression at 3 months.

Comparison 4 Depression, Outcome 2 Depression at 6 months.
Figuras y tablas -
Analysis 4.2

Comparison 4 Depression, Outcome 2 Depression at 6 months.

Comparison 4 Depression, Outcome 3 Depression at 12 months.
Figuras y tablas -
Analysis 4.3

Comparison 4 Depression, Outcome 3 Depression at 12 months.

Comparison 5 Reduced use of violence, Outcome 1 Verbal aggression (Conflict Tactic Scale) ‐ 3 months.
Figuras y tablas -
Analysis 5.1

Comparison 5 Reduced use of violence, Outcome 1 Verbal aggression (Conflict Tactic Scale) ‐ 3 months.

Comparison 5 Reduced use of violence, Outcome 2 Family violence (Conflict Tactic Scale) ‐ 3 months.
Figuras y tablas -
Analysis 5.2

Comparison 5 Reduced use of violence, Outcome 2 Family violence (Conflict Tactic Scale) ‐ 3 months.

Comparison 6 Increased contact with family, Outcome 1 Percent of days living at home (Form 90) ‐ 3 months.
Figuras y tablas -
Analysis 6.1

Comparison 6 Increased contact with family, Outcome 1 Percent of days living at home (Form 90) ‐ 3 months.

Comparison 7 Social functioning, Outcome 1 Delinquent behaviours at 3 months.
Figuras y tablas -
Analysis 7.1

Comparison 7 Social functioning, Outcome 1 Delinquent behaviours at 3 months.

Comparison 7 Social functioning, Outcome 2 Delinquent behaviours at 6 months.
Figuras y tablas -
Analysis 7.2

Comparison 7 Social functioning, Outcome 2 Delinquent behaviours at 6 months.

Comparison 7 Social functioning, Outcome 3 Delinquent behaviours at 12 months.
Figuras y tablas -
Analysis 7.3

Comparison 7 Social functioning, Outcome 3 Delinquent behaviours at 12 months.

Comparison 8 Psychological functioning, Outcome 1 Internalising behaviours at 3 months.
Figuras y tablas -
Analysis 8.1

Comparison 8 Psychological functioning, Outcome 1 Internalising behaviours at 3 months.

Comparison 8 Psychological functioning, Outcome 2 Internalising behaviours at 6 months.
Figuras y tablas -
Analysis 8.2

Comparison 8 Psychological functioning, Outcome 2 Internalising behaviours at 6 months.

Comparison 8 Psychological functioning, Outcome 3 Internalising behaviours at 12 months.
Figuras y tablas -
Analysis 8.3

Comparison 8 Psychological functioning, Outcome 3 Internalising behaviours at 12 months.

Comparison 8 Psychological functioning, Outcome 4 Externalising behaviours at 3 months.
Figuras y tablas -
Analysis 8.4

Comparison 8 Psychological functioning, Outcome 4 Externalising behaviours at 3 months.

Comparison 8 Psychological functioning, Outcome 5 Externalising behaviours at 6 months.
Figuras y tablas -
Analysis 8.5

Comparison 8 Psychological functioning, Outcome 5 Externalising behaviours at 6 months.

Comparison 8 Psychological functioning, Outcome 6 Externalising behaviours at 12 months.
Figuras y tablas -
Analysis 8.6

Comparison 8 Psychological functioning, Outcome 6 Externalising behaviours at 12 months.

Comparison 8 Psychological functioning, Outcome 7 Number of psychiatric diagnoses.
Figuras y tablas -
Analysis 8.7

Comparison 8 Psychological functioning, Outcome 7 Number of psychiatric diagnoses.

Comparison 9 Family functioning, Outcome 1 Family cohesion (Family Environment Scale) ‐ 3 months.
Figuras y tablas -
Analysis 9.1

Comparison 9 Family functioning, Outcome 1 Family cohesion (Family Environment Scale) ‐ 3 months.

Comparison 9 Family functioning, Outcome 2 Family conflict (Family Environment Scale) ‐ 3 months.
Figuras y tablas -
Analysis 9.2

Comparison 9 Family functioning, Outcome 2 Family conflict (Family Environment Scale) ‐ 3 months.

Comparison 9 Family functioning, Outcome 3 Parental care (Parental Bonding Instrument) ‐ 3 months.
Figuras y tablas -
Analysis 9.3

Comparison 9 Family functioning, Outcome 3 Parental care (Parental Bonding Instrument) ‐ 3 months.

Comparison 9 Family functioning, Outcome 4 Parental overprotection (Parental Bonding Instrument) ‐ 3 months.
Figuras y tablas -
Analysis 9.4

Comparison 9 Family functioning, Outcome 4 Parental overprotection (Parental Bonding Instrument) ‐ 3 months.

Therapeutic intervention compared with service as usual for street‐connected children and young people

Patient or population: street‐connected children and young people

Settings: shelters and drop‐in centres

Intervention: various specific therapeutic types of interventions

Comparison: shelter/drop‐in service as usual

Outcome categories (summarised)

Impact

Number of
studies (Note: studies for different outcomes overlap)

Quality of the evidence
(GRADE)

Primary outcome ‐ reintegration

  • Promote inclusion and reintegration

  • Increase literacy and numeracy

  • IIncrease access to education and employment

Reintegration was not measured in any of the studies. Similarly, access to literacy, numeracy, education and employment were not measured in any of the studies that met the criteria for inclusion. However, social stability was measured in 1 study and delinquent behaviours in 4 studies. Social stability outcomes measured in 1 study showed benefit for the intervention group. Delinquent behaviour results were mixed across studies; investigators used different types and constructs of measurement, so findings cannot be summarised

1

4

Moderatea

Promotion of mental health, including self esteem

Outcomes included in this category included depression, internalising and externalising behaviours, self esteem and psychiatric diagnoses measured on various scales. None of these measures showed overall differences between intervention and control groups, and change score calculations demonstrated that for the most part, both groups improved from baseline. These results indicate that for mental health promotion outcomes, the therapeutic intervention did not obtain significantly better outcomes than the service as usual/control condition in the studies included in this review

8

Moderatea

Reduction in harms associated with substance misuse

Substance misuse was measured in a wide variety of ways and includes alcohol misuse and different categories of non‐prescription drugs, as well as a scale measuring 'problem consequences'. The overall picture emerging form the included studies on these outcomes is unclear, possibly because of the array of measurement types and tools that measure subtly different constructs and differing time windows that were impossible to combine statistically. Results are mixed across studies, with some showing marginal or no differences between groups, and others showing clear benefit for intervention or control. Improvements in some substance misuse measures were noted in all 3 family intervention studies

8

Moderatea

Reduction in harms associated with early sexual activity

Sexually risky behaviour was similarly measured in different ways, including numbers of partners, numbers of times had sex, HIV knowledge, unprotected sex, condom use and rates of abstinence. Again, the picture across studies is mixed. Some studies showed benefit in 1 or another group, but it is difficult to untangle whether this shows benefit of a particular intervention or control condition, or whether this reflects differences in measurement approach

5

Lowb

Family functioning

These outcomes were measured by two studies that utilised family‐based approaches to providing intervention. No differences were found between intervention and control conditions on most of the outcome measures used. These included various aspects of family life such as parenting style, aggression and violence, family conflict and percent days living at home

2

Lowc

Overall picture

Participants in studies remained for the most part at a similar level or improved on outcomes measured. Assessment of the grade of evidence is moderate overall, as whilst some domains of bias (e.g. allocation concealment) were assessed mostly as having low risk of bias, other domains such as blinding, were assessed consistently as high risk, whilst selective reporting was consistently assessed as unclear. No clear examples showed deteriorated outcomes. Findings may be more generalisable to young people in low‐ and middle‐income countries with circumstances more similar to those included in the studies (i.e. those who have left home because of abuse or family conflict

Total studies included = 13

Moderatea

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate
Very low quality: We are very uncertain about the estimate

Summarised outcome categories used in Summary of findings (SoF) table in the interest of space

aOverall, the quality of the evidence was assessed as 'moderate' in the context of typical study quality in comparable areas (psychosocial interventions with at‐risk populations), and standard quality criteria were used in Cochrane reviews (in particular, the GRADE evaluation framework as utilised here). Quality of evidence for all available outcome categories was upgraded because they were based on robust study designs (RCTs); reasonably low drop‐out rates (for the study population involved); some analysis of major confounders including age and gender, and publication of data for a broad range of outcomes, including non‐significant outcomes, measured over reasonably long follow‐up periods, in most included studies. Quality of evidence was downgraded for the following reasons: heterogeneity of study outcomes, measures and types of statistical analysis used; inconsistency in measures, findings and analyses across outcomes and across studies with similar interventions; reliance on self report; use of convenience samples; over‐representation of studies from one study team; and questions over study generalisability. Further, few studies involved a control condition receiving no services, and some did not involve a service as usual condition, reducing comparability across studies. Finally, the relationship between intervention theories and outcomes measured remained unclear, and clinical and subjective significance of outcomes was explored in a small number of included studies. No participatory or process evaluations were available

bAs above, but the quality of the evidence was further downgraded because of the relatively small number of heterogeneous studies

cAs above, but the quality of the evidence was further downgraded because of the small number of studies available. The two included studies were conducted by the same study team.

Figuras y tablas -
Table 1. Outcomes (data included in meta‐analysis)

Number*

Outcome name

Study

Measure

≤1 month

3 months

6 months

12 months

Number of times participant had sex in last 90 days

Slesnick 2007/08

HRQ

x

x

Milburn 2012

Own

x

x

Number of sexual partners

Slesnick 2007/08

HRQ

x

x

Peterson 2006

Own

x

x

Alcohol use (number of days in last 30 days)

Baer 2007

TLFB

x

x

Peterson 2006

TLFB

x

x

Alcohol use (% days in last 90 days)

Slesnick 2005

Form 90

x

x

x

Slesnick 2009 EBFT

Form 90

x

Slesnick 2009 FFT

Form 90

x

Carmona 2014/Slesnick 2015 CM

Form 90

x

x

x

Carmona 2014/Slesnick 2015 CRA

Form 90

x

x

x

Carmona 2014/Slesnick 2015 MET

Form 90

x

x

x

Number of standard drinks (in last 90 days)

Slesnick 2009 EBFT

Form 90

x

Slesnick 2009 FFT

Form 90

x

Alcohol use (total score)

Slesnick 2009 EBFT

ADI

x

Slesnick 2009 FFT

ADI

x

Alcohol/drug use (% days in last 90 days)

Slesnick 2005

Form 90

x

Slesnick 2009 EBFT

Form 90

x

Slesnick 2009 FFT

Form 90

x

Slesnick 2013/Guo 2014 CRA

Form 90

x

x

x

Slesnick 2013/Guo 2014 EBFT

Form 90

x

x

x

Slesnick 2013/Guo 2014 MET

Form 90

x

x

x

Only/any drug use (% days in last 90 days)

Slesnick 2005

Form 90

x

x

x

Slesnick 2009 EBFT

Form 90

x

Slesnick 2009 FFT

Form 90

x

Carmona 2014/Slesnick 2015 CM

Form 90

x

x

x

Carmona 2014/Slesnick 2015 CRA

Form 90

x

x

x

Carmona 2014/Slesnick 2015 MET

Form 90

x

x

x

Marijuana use (number of days in last 30 days)

Baer 2007

TLFB

x

x

Peterson 2006

TLFB

x

x

Drug use other than marijuana (number of days

in last 30 days)

Baer 2007

TLFB

x

x

Peterson 2006

TLFB

x

x

Number of problem consequences

Slesnick 2005

POSIT

x

x

Slesnick 2007/08

POSIT

x

Slesnick 2009 EBFT

POSIT

x

Slesnick 2009 FFT

POSIT

x

Number of substance use diagnoses

Slesnick 2009 EBFT

CDISC

x

Slesnick 2009 FFT

CDISC

x

Number of categories of drug use (last 90 days)

Slesnick 2005

Form 90

x

Slesnick 2007/08

Form 90

x

Self esteem

Cauce 1994

RSES

x

Hyun 2005

SEI

x

Depression

Cauce 1994

RADS

x

Hyun 2005

BDI

x

Slesnick 2005

BDI

x

x

x

Slesnick 2007/08

BDI

x

Slesnick 2009 EBFT

BDI

x

Slesnick 2009 FFT

BDI

x

Slesnick 2013/Guo 2014 CRA

BDI

x

x

x

Slesnick 2013/Guo 2014 EBFT

BDI

x

x

x

Slesnick 2013/Guo 2014 MET

BDI

x

x

x

Carmona 2014/Slesnick 2015 CM

BDI

x

x

x

Carmona 2014/Slesnick 2015 CRA

BDI

x

x

x

Carmona 2014/Slesnick 2015 MET

BDI

x

x

x

Verbal aggression (youth)

Slesnick 2005

CTS

x

Slesnick 2009 EBFT

CTS

x

Slesnick 2009 FFT

CTS

x

Family violence (youth)

Slesnick 2005

CTS

x

Slesnick 2009 EBFT

CTS

x

Slesnick 2009 FFT

CTS

x

Days living at home (% days in last 90 days)

Slesnick 2009 EBFT

Form 90

x

Slesnick 2009 FFT

Form 90

x

Delinquent behaviours

Cauce 1994

YSR

x

Milburn 2012

DSM‐IV

x

x

x

Slesnick 2005

NYSDS

x

x

x

Slesnick 2007/08

NYSDS

x

Slesnick 2009 EBFT

NYSDS

x

Slesnick 2009 FFT

NYSDS

x

Internalising problems

Cauce 1994

YSR

x

Slesnick 2005

YSR

x

x

x

Slesnick 2007/08

YSR

x

Slesnick 2009 EBFT

YSR

x

Slesnick 2009 FFT

YSR

x

Slesnick 2013/Guo 2014 CRA

YSR

x

x

x

Slesnick 2013/Guo 2014 EBFT

YSR

x

x

x

Slesnick 2013/Guo 2014 MET

YSR

x

x

x

Carmona 2014/Slesnick 2015 CM

YSR

x

x

x

Carmona 2014/Slesnick 2015 CRA

YSR

x

x

x

Carmona 2014/Slesnick 2015 MET

YSR

x

x

x

Externalising problems

Cauce 1994

YSR

x

Slesnick 2005

YSR

x

x

x

Slesnick 2007/08

YSR

x

Slesnick 2009 EBFT

YSR

x

Slesnick 2009 FFT

YSR

x

Slesnick 2013/Guo 2014 CRA

YSR

x

x

x

Slesnick 2013/Guo 2014 EBFT

YSR

x

x

x

Slesnick 2013/Guo 2014 MET

YSR

x

x

x

Carmona 2014/Slesnick 2015 CM

YSR

x

x

x

Carmona 2014/Slesnick 2015 CRA

YSR

x

x

x

Carmona 2014/Slesnick 2015 MET

YSR

x

x

x

Number of psychiatric diagnoses

Slesnick 2005

CDISC

x

Slesnick 2009 EBFT

CDISC

x

Slesnick 2009 FFT

CDISC

x

Family cohesion

Slesnick 2005

FES

x

Slesnick 2009 EBFT

FES

x

Slesnick 2009 FFT

FES

x

Family conflict

Slesnick 2005

FES

x

Slesnick 2009 EBFT

FES

x

Slesnick 2009 FFT

FES

x

Parental care

Slesnick 2005

PBI

x

Slesnick 2009 EBFT

PBI

x

Slesnick 2009 FFT

PBI

x

Parental overprotectiveness

Slesnick 2005

PBI

x

Slesnick 2009 EBFT

PBI

x

Slesnick 2009 FFT

PBI

x

Number

Outcome name

Study

Measure

≤1 month

3 months

6 months

12 months

Gaps occur when absence of relevant data was noted in relation to particular outcomes defined in the protocol

Figuras y tablas -
Table 1. Outcomes (data included in meta‐analysis)
Comparison 1. Safer or reduced sexual activity

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Number of times had sex ‐ 3 months Show forest plot

2

239

Mean Difference (IV, Random, 95% CI)

‐0.56 [‐1.13, 0.01]

2 Number of times had sex ‐ 6 months Show forest plot

2

242

Mean Difference (IV, Random, 95% CI)

0.73 [‐2.97, 4.43]

3 Number of sexual partners ‐ 3 months Show forest plot

2

239

Mean Difference (IV, Random, 95% CI)

‐0.04 [‐0.25, 0.17]

4 Number of sexual partners ‐ 6 months Show forest plot

2

242

Mean Difference (IV, Random, 95% CI)

‐0.04 [‐0.22, 0.13]

Figuras y tablas -
Comparison 1. Safer or reduced sexual activity
Comparison 2. Safer or reduced substance use

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Number of days used alcohol in last month ‐ 1 month Show forest plot

2

235

Mean Difference (IV, Random, 95% CI)

‐0.33 [‐2.25, 1.59]

2 Number of days used alcohol in last month ‐ 3 months Show forest plot

2

235

Mean Difference (IV, Random, 95% CI)

1.10 [‐0.67, 2.88]

3 Percent days of alcohol use in last 90 days (Form 90) ‐ 3 months Show forest plot

5

383

Mean Difference (IV, Random, 95% CI)

0.03 [‐1.86, 1.93]

4 Percent days of alcohol use in last 90 days (Form 90) ‐ 6 months Show forest plot

3

295

Mean Difference (IV, Random, 95% CI)

1.05 [‐1.76, 3.86]

5 Percent days of alcohol use in last 90 days (Form 90) ‐ 12 months Show forest plot

3

304

Mean Difference (IV, Random, 95% CI)

0.63 [‐2.23, 3.48]

6 Number of standard drinks (Form 90) ‐ 3 months Show forest plot

2

75

Mean Difference (IV, Random, 95% CI)

‐2.87 [‐5.68, ‐0.07]

7 Adolescent Drinking Index ‐ 3 months Show forest plot

2

75

Mean Difference (IV, Random, 95% CI)

1.08 [‐4.42, 6.57]

8 Percent days of alcohol/drug use (excl tobacco) (Form 90) ‐ 3 months Show forest plot

4

214

Mean Difference (IV, Random, 95% CI)

‐0.70 [‐9.09, 7.70]

9 Percent days of alcohol/drug use (excl tobacco) (Form 90) ‐ 6 months Show forest plot

3

278

Mean Difference (IV, Random, 95% CI)

‐2.15 [‐9.82, 5.53]

10 Percent days of alcohol/drug use (excl tobacco) (Form 90) ‐ 12 months Show forest plot

2

127

Mean Difference (IV, Random, 95% CI)

5.87 [‐5.06, 16.79]

11 Percent days only/any drug use (Form 90) ‐ 3 months Show forest plot

5

384

Mean Difference (IV, Random, 95% CI)

0.67 [‐6.82, 8.15]

12 Percent days only/any drug use (Form 90) ‐ 6 months Show forest plot

3

295

Mean Difference (IV, Random, 95% CI)

‐2.28 [‐11.53, 6.96]

13 Percent days only/any drug use (Form 90) ‐ 12 months Show forest plot

3

304

Mean Difference (IV, Random, 95% CI)

‐5.28 [‐13.79, 3.23]

14 Number of days used marijuana in last month ‐ 1 month Show forest plot

2

235

Mean Difference (IV, Random, 95% CI)

‐0.52 [‐3.65, 2.62]

15 Number of days used marijuana in last month ‐ 3 months Show forest plot

2

235

Mean Difference (IV, Random, 95% CI)

0.37 [‐2.73, 3.47]

16 Number of days used other drugs in last month ‐ 1 month Show forest plot

2

204

Mean Difference (IV, Random, 95% CI)

1.21 [‐0.68, 3.10]

17 Number of days used other drugs in last month ‐ 3 months Show forest plot

2

204

Mean Difference (IV, Random, 95% CI)

0.22 [‐1.84, 2.28]

18 Number of problem consequences ‐ 3 months Show forest plot

3

182

Mean Difference (IV, Random, 95% CI)

1.51 [0.56, 2.47]

19 Number of problem consequences ‐ 6 months Show forest plot

2

261

Mean Difference (IV, Random, 95% CI)

0.34 [‐0.67, 1.34]

20 Number of substance use diagnoses (CDISC) ‐ 3 months Show forest plot

2

75

Mean Difference (IV, Random, 95% CI)

‐0.70 [‐1.27, ‐0.14]

21 Number of categories of drug use (Form 90) ‐ 6 months Show forest plot

2

261

Mean Difference (IV, Random, 95% CI)

0.14 [‐0.33, 0.61]

Figuras y tablas -
Comparison 2. Safer or reduced substance use
Comparison 3. Self esteem

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Self esteem at endpoint Show forest plot

2

142

Std. Mean Difference (IV, Random, 95% CI)

0.11 [‐0.22, 0.44]

Figuras y tablas -
Comparison 3. Self esteem
Comparison 4. Depression

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Depression at 3 months Show forest plot

9

661

Std. Mean Difference (IV, Random, 95% CI)

‐0.03 [‐0.22, 0.17]

2 Depression at 6 months Show forest plot

6

586

Mean Difference (IV, Random, 95% CI)

0.83 [‐0.88, 2.55]

3 Depression at 12 months Show forest plot

5

441

Mean Difference (IV, Random, 95% CI)

1.28 [‐0.36, 2.92]

Figuras y tablas -
Comparison 4. Depression
Comparison 5. Reduced use of violence

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Verbal aggression (Conflict Tactic Scale) ‐ 3 months Show forest plot

3

208

Mean Difference (IV, Random, 95% CI)

‐0.00 [‐0.07, 0.06]

2 Family violence (Conflict Tactic Scale) ‐ 3 months Show forest plot

3

208

Mean Difference (IV, Random, 95% CI)

‐0.00 [‐0.02, 0.02]

Figuras y tablas -
Comparison 5. Reduced use of violence
Comparison 6. Increased contact with family

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Percent of days living at home (Form 90) ‐ 3 months Show forest plot

2

75

Mean Difference (IV, Random, 95% CI)

‐9.46 [‐27.96, 9.03]

Figuras y tablas -
Comparison 6. Increased contact with family
Comparison 7. Social functioning

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Delinquent behaviours at 3 months Show forest plot

5

404

Std. Mean Difference (IV, Random, 95% CI)

‐0.29 [‐0.54, ‐0.03]

2 Delinquent behaviours at 6 months Show forest plot

3

348

Std. Mean Difference (IV, Random, 95% CI)

‐0.07 [‐0.52, 0.37]

3 Delinquent behaviours at 12 months Show forest plot

2

177

Std. Mean Difference (IV, Random, 95% CI)

‐0.16 [‐1.05, 0.72]

Figuras y tablas -
Comparison 7. Social functioning
Comparison 8. Psychological functioning

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Internalising behaviours at 3 months Show forest plot

8

634

Mean Difference (IV, Random, 95% CI)

0.73 [‐0.87, 2.34]

2 Internalising behaviours at 6 months Show forest plot

6

582

Mean Difference (IV, Random, 95% CI)

0.30 [‐1.36, 1.97]

3 Internalising behaviours at 12 months Show forest plot

5

433

Mean Difference (IV, Random, 95% CI)

0.31 [‐1.58, 2.20]

4 Externalising behaviours at 3 months Show forest plot

8

636

Std. Mean Difference (IV, Random, 95% CI)

0.09 [‐0.10, 0.28]

5 Externalising behaviours at 6 months Show forest plot

6

583

Mean Difference (IV, Random, 95% CI)

0.83 [‐0.74, 2.41]

6 Externalising behaviours at 12 months Show forest plot

5

434

Mean Difference (IV, Random, 95% CI)

0.04 [‐2.89, 2.97]

7 Number of psychiatric diagnoses Show forest plot

3

182

Mean Difference (IV, Random, 95% CI)

‐0.06 [‐0.50, 0.37]

Figuras y tablas -
Comparison 8. Psychological functioning
Comparison 9. Family functioning

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Family cohesion (Family Environment Scale) ‐ 3 months Show forest plot

3

208

Mean Difference (IV, Random, 95% CI)

0.88 [0.23, 1.54]

2 Family conflict (Family Environment Scale) ‐ 3 months Show forest plot

3

208

Mean Difference (IV, Random, 95% CI)

‐0.05 [‐0.91, 0.81]

3 Parental care (Parental Bonding Instrument) ‐ 3 months Show forest plot

3

208

Mean Difference (IV, Random, 95% CI)

1.68 [‐0.63, 4.00]

4 Parental overprotection (Parental Bonding Instrument) ‐ 3 months Show forest plot

3

208

Mean Difference (IV, Random, 95% CI)

‐0.82 [‐4.75, 3.10]

Figuras y tablas -
Comparison 9. Family functioning