1 Dependent on modified Rankin score (mRS 3 to 5) Show forest plot

2

223

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.68, 0.97]

1.1 Fluoxetine

1

112

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.68, 0.97]

1.2 Sertraline

1

111

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

2 Disability Show forest plot

22

1310

Std. Mean Difference (IV, Random, 95% CI)

0.92 [0.62, 1.23]

2.1 Fluoxetine

13

708

Std. Mean Difference (IV, Random, 95% CI)

0.68 [0.31, 1.06]

2.2 Sertraline

1

130

Std. Mean Difference (IV, Random, 95% CI)

1.38 [0.99, 1.76]

2.3 Citalopram

3

179

Std. Mean Difference (IV, Random, 95% CI)

1.18 [‐0.22, 2.58]

2.4 Paroxetine

5

293

Std. Mean Difference (IV, Random, 95% CI)

1.31 [0.67, 1.95]

2.5 Escitalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2.6 Sertraline or fluoxetine

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3 Neurological deficit score Show forest plot

29

2011

Std. Mean Difference (IV, Random, 95% CI)

‐1.00 [‐1.26, ‐0.75]

3.1 Fluoxetine

17

1095

Std. Mean Difference (IV, Random, 95% CI)

‐0.93 [‐1.29, ‐0.57]

3.2 Sertraline

2

108

Std. Mean Difference (IV, Random, 95% CI)

‐0.26 [‐0.96, 0.45]

3.3 Citalopram

3

179

Std. Mean Difference (IV, Random, 95% CI)

‐1.43 [‐2.25, ‐0.60]

3.4 Paroxetine

6

455

Std. Mean Difference (IV, Random, 95% CI)

‐1.21 [‐1.68, ‐0.74]

3.5 Fluoxetine or sertraline

1

174

Std. Mean Difference (IV, Random, 95% CI)

‐1.40 [‐1.73, ‐1.06]

4 Depression (continuous data) Show forest plot

39

2728

Std. Mean Difference (IV, Random, 95% CI)

‐1.91 [‐2.34, ‐1.48]

4.1 Fluoxetine

21

1260

Std. Mean Difference (IV, Random, 95% CI)

‐1.97 [‐2.63, ‐1.32]

4.2 Sertraline

4

383

Std. Mean Difference (IV, Random, 95% CI)

‐0.13 [‐1.11, 0.85]

4.3 Citalopram

5

313

Std. Mean Difference (IV, Random, 95% CI)

‐1.92 [‐3.08, ‐0.75]

4.4 Paroxetine

8

598

Std. Mean Difference (IV, Random, 95% CI)

‐2.81 [‐3.66, ‐1.96]

4.5 Fluoxetine or sertraline

1

174

Std. Mean Difference (IV, Random, 95% CI)

‐1.50 [‐1.84, ‐1.16]

4.6 Escitalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

5 Depression (dichotomous data) Show forest plot

8

771

Risk Ratio (M‐H, Random, 95% CI)

0.43 [0.24, 0.77]

5.1 Fluoxetine

3

206

Risk Ratio (M‐H, Random, 95% CI)

0.31 [0.17, 0.57]

5.2 Sertraline

2

166

Risk Ratio (M‐H, Random, 95% CI)

0.59 [0.28, 1.25]

5.3 Citalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

5.4 Paroxetine

2

282

Risk Ratio (M‐H, Random, 95% CI)

0.53 [0.15, 1.92]

5.5 Escitalopram

1

117

Risk Ratio (M‐H, Random, 95% CI)

0.38 [0.14, 0.99]

6 Anxiety (continuous data) Show forest plot

8

413

Std. Mean Difference (IV, Random, 95% CI)

‐0.77 [‐1.52, ‐0.02]

6.1 Fluoxetine

4

169

Std. Mean Difference (IV, Random, 95% CI)

‐0.23 [‐0.67, 0.21]

6.2 Sertraline

1

50

Std. Mean Difference (IV, Random, 95% CI)

0.36 [‐0.20, 0.92]

6.3 Citalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6.4 Paroxetine

3

194

Std. Mean Difference (IV, Random, 95% CI)

‐1.97 [‐3.81, ‐0.12]

6.5 Escitalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

7 Anxiety (dichotomous data)

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

8 Cognition (continuous scores end of treatment) Show forest plot

7

425

Std. Mean Difference (IV, Random, 95% CI)

0.32 [‐0.23, 0.86]

8.1 Fluoxetine

4

158

Std. Mean Difference (IV, Random, 95% CI)

0.04 [‐0.27, 0.35]

8.2 Sertraline

1

80

Std. Mean Difference (IV, Random, 95% CI)

0.53 [0.08, 0.98]

8.3 Citalopram

1

99

Std. Mean Difference (IV, Random, 95% CI)

1.69 [1.23, 2.16]

8.4 Escitalopram

1

88

Std. Mean Difference (IV, Random, 95% CI)

‐0.07 [‐0.49, 0.35]

9 Death Show forest plot

46

3344

Risk Ratio (M‐H, Random, 95% CI)

0.76 [0.34, 1.70]

9.1 Fluoxetine

25

1502

Risk Ratio (M‐H, Random, 95% CI)

0.78 [0.14, 4.39]

9.2 Sertraline

5

461

Risk Ratio (M‐H, Random, 95% CI)

0.91 [0.20, 4.19]

9.3 Citalopram

5

341

Risk Ratio (M‐H, Random, 95% CI)

0.77 [0.17, 3.38]

9.4 Paroxetine

9

739

Risk Ratio (M‐H, Random, 95% CI)

0.2 [0.01, 4.01]

9.5 Escitalopram

1

117

Risk Ratio (M‐H, Random, 95% CI)

4.92 [0.24, 100.25]

9.6 Sertraline or fluoxetine

1

184

Risk Ratio (M‐H, Random, 95% CI)

0.2 [0.01, 4.11]

10 Seizures Show forest plot

7

444

Risk Ratio (M‐H, Random, 95% CI)

2.67 [0.61, 11.63]

10.1 Fluoxetine

5

318

Risk Ratio (M‐H, Random, 95% CI)

2.19 [0.41, 11.85]

10.2 Sertraline

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.3 Citalopram

1

66

Risk Ratio (M‐H, Random, 95% CI)

5.0 [0.25, 100.32]

10.4 Paroxetine

1

60

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.5 Escitalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.6 Sertraline or fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11 Gastrointestinal side effects Show forest plot

14

902

Risk Ratio (M‐H, Random, 95% CI)

1.90 [0.94, 3.85]

11.1 Fluoxetine

11

760

Risk Ratio (M‐H, Random, 95% CI)

1.68 [0.82, 3.42]

11.2 Sertraline

1

28

Risk Ratio (M‐H, Random, 95% CI)

0.33 [0.01, 7.55]

11.3 Citalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11.4 Paroxetine

2

114

Risk Ratio (M‐H, Random, 95% CI)

10.21 [1.32, 78.77]

11.5 Escitalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11.6 Sertraline and paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12 Bleeding Show forest plot

2

347

Risk Ratio (M‐H, Random, 95% CI)

1.63 [0.20, 13.05]

12.1 Fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.2 Sertraline

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.3 Citalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.4 Paroxetine

1

229

Risk Ratio (M‐H, Random, 95% CI)

3.13 [0.13, 76.10]

12.5 Escitalopram

1

118

Risk Ratio (M‐H, Random, 95% CI)

1.0 [0.06, 15.61]

12.6 Sertraline or fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

13 Change in depression scores between baseline and follow‐up

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

13.1 Sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

14 Change in cognition between baseline and end of treatment Show forest plot

1

99

Std. Mean Difference (IV, Random, 95% CI)

0.0 [‐0.39, 0.39]

14.1 Sertraline

1

99

Std. Mean Difference (IV, Random, 95% CI)

0.0 [‐0.39, 0.39]

15 Leaving the trial before the end of scheduled follow‐up Show forest plot

49

3851

Risk Ratio (M‐H, Random, 95% CI)

1.02 [0.86, 1.21]

15.1 Fluoxetine

25

1585

Risk Ratio (M‐H, Random, 95% CI)

1.21 [0.87, 1.67]

15.2 Sertraline

6

609

Risk Ratio (M‐H, Random, 95% CI)

0.95 [0.69, 1.32]

15.3 Citalopram

5

339

Risk Ratio (M‐H, Random, 95% CI)

1.20 [0.41, 3.47]

15.4 Paroxetine

11

1017

Risk Ratio (M‐H, Random, 95% CI)

0.88 [0.51, 1.52]

15.5 Sertraline or fluoxetine

1

184

Risk Ratio (M‐H, Random, 95% CI)

1.0 [0.26, 3.88]

15.6 Escitalopram

1

117

Risk Ratio (M‐H, Random, 95% CI)

1.38 [0.46, 4.09]

16 Motor deficits Show forest plot

2

145

Std. Mean Difference (IV, Random, 95% CI)

‐0.33 [‐1.22, 0.56]

16.1 Fluoxetine

2

145

Std. Mean Difference (IV, Random, 95% CI)

‐0.33 [‐1.22, 0.56]

1 Dependent on modified Rankin score Show forest plot

1

94

Risk Ratio (M‐H, Random, 95% CI)

0.38 [0.02, 9.04]

1.1 Sertraline

1

94

Risk Ratio (M‐H, Random, 95% CI)

0.38 [0.02, 9.04]

1.2 Fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

2 Disability Show forest plot

2

155

Std. Mean Difference (IV, Random, 95% CI)

1.78 [‐1.01, 4.57]

3 Neurological deficit score (higher score: worse outcome) Show forest plot

4

275

Std. Mean Difference (IV, Random, 95% CI)

‐0.63 [‐1.30, 0.04]

3.1 Fluoxetine

3

195

Std. Mean Difference (IV, Random, 95% CI)

‐0.77 [‐1.61, 0.08]

3.2 Sertraline

1

80

Std. Mean Difference (IV, Random, 95% CI)

‐0.25 [‐0.69, 0.19]

4 Depression (continuous data) Show forest plot

4

275

Std. Mean Difference (IV, Random, 95% CI)

‐1.10 [‐2.16, ‐0.04]

4.1 Fluoxetine

3

195

Std. Mean Difference (IV, Random, 95% CI)

‐1.32 [‐2.74, 0.11]

4.2 Sertraline

1

80

Std. Mean Difference (IV, Random, 95% CI)

‐0.47 [‐0.91, ‐0.03]

5 Depression (dichotomous data) Show forest plot

1

99

Risk Ratio (M‐H, Random, 95% CI)

0.77 [0.34, 1.76]

5.1 Sertraline

1

99

Risk Ratio (M‐H, Random, 95% CI)

0.77 [0.34, 1.76]

6 Cognition (higher score is better) Show forest plot

1

80

Std. Mean Difference (IV, Random, 95% CI)

0.26 [‐0.18, 0.70]

6.1 Sertraline

1

80

Std. Mean Difference (IV, Random, 95% CI)

0.26 [‐0.18, 0.70]

7 Change in cognition between baseline and follow‐up Show forest plot

1

99

Std. Mean Difference (IV, Random, 95% CI)

0.02 [‐0.37, 0.42]

7.1 Sertraline

1

99

Std. Mean Difference (IV, Random, 95% CI)

0.02 [‐0.37, 0.42]

8 Death Show forest plot

3

257

Risk Ratio (M‐H, Random, 95% CI)

0.08 [0.00, 1.41]

1 Dependent on modified Rankin score Show forest plot

2

223

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.68, 0.97]

1.1 Mean time since stroke < 2 weeks

2

223

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.68, 0.97]

1.2 Mean time since stroke 2 weeks to 3 months at randomisation

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

1.3 Mean time since stroke 3 to 6 months at randomisation

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

1.4 Mean time since stroke > 6 months and < 9 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

1.5 Mean time since stroke at randomisation 9 to 12 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

1.6 Mean time since stroke not known

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

2 Disability Show forest plot

22

1310

Std. Mean Difference (IV, Random, 95% CI)

0.92 [0.62, 1.23]

2.1 Mean time since stroke < 3 months

17

1004

Std. Mean Difference (IV, Random, 95% CI)

0.77 [0.47, 1.06]

2.2 Mean time since stroke 3 to 6 months at randomisation

1

32

Std. Mean Difference (IV, Random, 95% CI)

0.43 [‐0.27, 1.14]

2.3 Mean time since stroke > 6 months and < 9 months

1

60

Std. Mean Difference (IV, Random, 95% CI)

2.67 [1.97, 3.38]

2.4 Mean time since stroke 9 to 12 months

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2.5 Mean time since stroke not known

3

214

Std. Mean Difference (IV, Random, 95% CI)

1.43 [0.40, 2.45]

3 Neurological deficit score Show forest plot

29

2011

Std. Mean Difference (IV, Random, 95% CI)

‐1.00 [‐1.26, ‐0.75]

3.1 Mean time since stroke < 3 months

19

1183

Std. Mean Difference (IV, Random, 95% CI)

‐1.01 [‐1.31, ‐0.72]

3.2 Mean time since stroke 3 to 6 months

1

32

Std. Mean Difference (IV, Random, 95% CI)

‐0.27 [‐0.97, 0.42]

3.3 Mean time since stroke 6 to 9 months

2

140

Std. Mean Difference (IV, Random, 95% CI)

‐1.40 [‐3.08, 0.28]

3.4 Mean time since stroke 9 to 12 months

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3.5 Mean time since stroke not known

7

656

Std. Mean Difference (IV, Random, 95% CI)

‐0.96 [‐1.56, ‐0.36]

4 Depression (continuous) Show forest plot

39

2728

Std. Mean Difference (IV, Random, 95% CI)

‐1.91 [‐2.34, ‐1.48]

4.1 Time since stroke < 3 months

27

1697

Std. Mean Difference (IV, Random, 95% CI)

‐1.96 [‐2.54, ‐1.37]

4.2 Time since stroke 3 to 6 months

3

223

Std. Mean Difference (IV, Random, 95% CI)

‐1.16 [‐2.97, 0.65]

4.3 Time since stroke 6 to 9 months

2

140

Std. Mean Difference (IV, Random, 95% CI)

‐1.56 [‐3.99, 0.86]

4.4 Time since stroke 9 to 12 months

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

4.5 Time since stroke not known

7

668

Std. Mean Difference (IV, Random, 95% CI)

‐2.19 [‐2.62, ‐1.76]

5 Depression (dichotomous) Show forest plot

8

771

Risk Ratio (M‐H, Random, 95% CI)

0.43 [0.24, 0.77]

5.1 Time since stroke < 3 months

7

546

Risk Ratio (M‐H, Random, 95% CI)

0.39 [0.26, 0.57]

5.2 Time since stroke 3 to 6 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

5.3 Time since stroke 6 to 9 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

5.4 Time since stroke 9 to 12 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

5.5 Time since stroke unknown

1

225

Risk Ratio (M‐H, Random, 95% CI)

0.87 [0.76, 0.99]

6 Anxiety (dichotomous)

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

6.1 Time since stroke < 3 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

6.2 Time since stroke 3 to 6 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

6.3 Time since stroke 6 to 9 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

6.4 Time since stroke 9 to 12 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

6.5 Time from stroke onset unknown

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

7 Anxiety (continuous) Show forest plot

8

413

Std. Mean Difference (IV, Random, 95% CI)

‐0.77 [‐1.52, ‐0.02]

7.1 Time since stroke < 3 months

8

413

Std. Mean Difference (IV, Random, 95% CI)

‐0.77 [‐1.52, ‐0.02]

7.2 Time since stroke 3 to 6 months

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

7.3 Time since stroke 6 to 9 months

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

7.4 Time since stroke 9 to 12 months

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

7.5 Time since stroke unknown

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8 Cognition Show forest plot

7

425

Std. Mean Difference (IV, Random, 95% CI)

0.32 [‐0.23, 0.86]

8.1 Time since stroke < 3 months

5

273

Std. Mean Difference (IV, Random, 95% CI)

0.28 [‐0.57, 1.13]

8.2 Time since stroke 3 to 6 months

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8.3 Time since stroke 6 to 9 months

1

80

Std. Mean Difference (IV, Random, 95% CI)

0.53 [0.08, 0.98]

8.4 Time since stroke 9 to 12 months

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8.5 Time since stroke unknown

1

72

Std. Mean Difference (IV, Random, 95% CI)

0.23 [‐0.23, 0.69]

9 Death Show forest plot

46

3404

Risk Ratio (M‐H, Random, 95% CI)

0.76 [0.34, 1.70]

9.1 Time since stroke < 3 months

34

2311

Risk Ratio (M‐H, Random, 95% CI)

0.94 [0.38, 2.36]

9.2 Time since stroke 3 to 6 months

4

369

Risk Ratio (M‐H, Random, 95% CI)

0.20 [0.01, 4.02]

9.3 Time since stroke 6 to 9 months

2

140

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

9.4 Time since stroke 9 to 12 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

9.5 Time since stroke unknown

7

584

Risk Ratio (M‐H, Random, 95% CI)

0.49 [0.07, 3.65]

10 Seizure Show forest plot

7

444

Risk Ratio (M‐H, Random, 95% CI)

2.67 [0.61, 11.63]

10.1 Time since stroke < 3 months

6

409

Risk Ratio (M‐H, Random, 95% CI)

2.22 [0.41, 12.06]

10.2 Time since stroke 3 to 6 months

1

35

Risk Ratio (M‐H, Random, 95% CI)

4.74 [0.24, 92.07]

10.3 Time since stroke 6 to 9 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.4 Time since stroke 9 to 12 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.5 Time since stroke unknown

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11 Gastrointestinal side effects Show forest plot

14

902

Risk Ratio (M‐H, Random, 95% CI)

1.90 [0.94, 3.85]

11.1 Time since stroke < 3 months

11

767

Risk Ratio (M‐H, Random, 95% CI)

1.92 [0.83, 4.45]

11.2 Time since stroke 3 to 6 months

1

35

Risk Ratio (M‐H, Random, 95% CI)

4.74 [0.24, 92.07]

11.3 Time since stroke 6 to 9 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11.4 Time since stroke 9 to 12 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11.5 Time since stroke unknown

2

100

Risk Ratio (M‐H, Random, 95% CI)

1.51 [0.14, 16.29]

12 Leaving the trial early Show forest plot

49

3851

Risk Ratio (M‐H, Random, 95% CI)

1.02 [0.86, 1.21]

12.1 Time since stroke < 3 months

34

2435

Risk Ratio (M‐H, Random, 95% CI)

1.12 [0.90, 1.40]

12.2 Time since stroke 3 to 6 months

3

246

Risk Ratio (M‐H, Random, 95% CI)

0.83 [0.59, 1.19]

12.3 Time since stroke 6 to 9 months

2

140

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.4 Time since stroke 9 to 12 months

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.5 Time since stroke not known

10

1030

Risk Ratio (M‐H, Random, 95% CI)

0.97 [0.62, 1.51]

13 Bleeding Show forest plot

2

347

Risk Ratio (M‐H, Random, 95% CI)

1.63 [0.20, 13.05]

13.1 Time since stroke < 3 months

1

118

Risk Ratio (M‐H, Random, 95% CI)

1.0 [0.06, 15.61]

13.2 Time since stroke not known

1

229

Risk Ratio (M‐H, Random, 95% CI)

3.13 [0.13, 76.10]

14 Motor deficits Show forest plot

2

145

Std. Mean Difference (IV, Random, 95% CI)

‐0.33 [‐1.22, 0.56]

14.1 < 3 months

1

113

Std. Mean Difference (IV, Random, 95% CI)

‐0.74 [‐1.12, ‐0.35]

14.2 3 to 6 months

1

32

Std. Mean Difference (IV, Random, 95% CI)

0.18 [‐0.52, 0.87]

1 Modified Rankin score Show forest plot

2

223

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.68, 0.97]

1.1 Had to have depression at recruitment

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

1.2 Did not have to have depression at recruitment

2

223

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.68, 0.97]

2 Disability Show forest plot

22

1310

Std. Mean Difference (IV, Random, 95% CI)

0.92 [0.62, 1.23]

2.1 Had to have depression at recruitment

15

986

Std. Mean Difference (IV, Random, 95% CI)

1.11 [0.71, 1.51]

2.2 Did not have to have depression at onset

7

324

Std. Mean Difference (IV, Random, 95% CI)

0.55 [0.27, 0.84]

3 Neurological deficit score Show forest plot

29

2011

Std. Mean Difference (IV, Random, 95% CI)

‐1.00 [‐1.26, ‐0.75]

3.1 Had to have depression at recruitment

19

1420

Std. Mean Difference (IV, Random, 95% CI)

‐1.19 [‐1.47, ‐0.91]

3.2 Did not have to have depression at recruitment

10

591

Std. Mean Difference (IV, Random, 95% CI)

‐0.63 [‐1.08, ‐0.17]

4 Depression (continuous) Show forest plot

39

2728

Std. Mean Difference (IV, Random, 95% CI)

‐1.91 [‐2.34, ‐1.48]

4.1 Had to have depression at recruitment

31

2256

Std. Mean Difference (IV, Random, 95% CI)

‐2.06 [‐2.54, ‐1.58]

4.2 Did not have to have depression at recruitment

8

472

Std. Mean Difference (IV, Random, 95% CI)

‐1.35 [‐2.35, ‐0.36]

5 Depression (dichotomous) Show forest plot

8

771

Risk Ratio (M‐H, Random, 95% CI)

0.43 [0.24, 0.77]

5.1 Had to have depression at recruitment

2

288

Risk Ratio (M‐H, Random, 95% CI)

0.66 [0.30, 1.46]

5.2 Did not have to have depression at recruitment

6

483

Risk Ratio (M‐H, Random, 95% CI)

0.38 [0.25, 0.59]

6 Anxiety (continuous) Show forest plot

8

413

Std. Mean Difference (IV, Random, 95% CI)

‐0.77 [‐1.52, ‐0.02]

6.1 Had to have depression at recruitment

5

271

Std. Mean Difference (IV, Random, 95% CI)

‐1.10 [‐2.32, 0.12]

6.2 Did not have to have depression at recruitment

3

142

Std. Mean Difference (IV, Random, 95% CI)

‐0.28 [‐0.85, 0.29]

7 Anxiety (dichotomous)

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

7.1 Had to have depression at recruitment

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

7.2 Did not have to have depression at baseline

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

8 Cognition Show forest plot

7

425

Std. Mean Difference (IV, Random, 95% CI)

0.32 [‐0.23, 0.86]

8.1 Had to have depression at recruitment

5

309

Std. Mean Difference (IV, Random, 95% CI)

0.48 [‐0.21, 1.17]

8.2 Did not have to have depression at recruitment

2

116

Std. Mean Difference (IV, Random, 95% CI)

‐0.08 [‐0.45, 0.28]

9 Death Show forest plot

46

3344

Risk Ratio (M‐H, Random, 95% CI)

0.76 [0.34, 1.70]

9.1 Had to have depression at recruitment

32

2468

Risk Ratio (M‐H, Random, 95% CI)

0.53 [0.18, 1.54]

9.2 Did not have to have depression at recruitment

14

876

Risk Ratio (M‐H, Random, 95% CI)

1.22 [0.36, 4.13]

10 Seizures Show forest plot

7

444

Risk Ratio (M‐H, Random, 95% CI)

2.67 [0.61, 11.63]

10.1 Had to have depression at recruitment

4

220

Risk Ratio (M‐H, Random, 95% CI)

1.97 [0.27, 14.55]

10.2 Did not have to have depression at recruitment

3

224

Risk Ratio (M‐H, Random, 95% CI)

3.83 [0.44, 33.53]

11 Gastrointestinal side effects Show forest plot

14

902

Risk Ratio (M‐H, Random, 95% CI)

1.90 [0.94, 3.85]

11.1 Had to have depression at recruitment

8

523

Risk Ratio (M‐H, Random, 95% CI)

1.72 [0.58, 5.12]

11.2 Did not have to have depression at recruitment

6

379

Risk Ratio (M‐H, Random, 95% CI)

2.53 [1.18, 5.42]

12 Leaving the trial early Show forest plot

49

3851

Risk Ratio (M‐H, Random, 95% CI)

1.02 [0.86, 1.21]

12.1 Had to have depression at recruitment

35

2860

Risk Ratio (M‐H, Random, 95% CI)

0.97 [0.77, 1.21]

12.2 Did not have to have depression at entry

14

991

Risk Ratio (M‐H, Random, 95% CI)

1.10 [0.84, 1.44]

13 Bleeding Show forest plot

2

347

Risk Ratio (M‐H, Random, 95% CI)

1.63 [0.20, 13.05]

13.1 Depression at onset

1

229

Risk Ratio (M‐H, Random, 95% CI)

3.13 [0.13, 76.10]

13.2 No depression at onset

1

118

Risk Ratio (M‐H, Random, 95% CI)

1.0 [0.06, 15.61]

14 Motor deficits Show forest plot

2

145

Std. Mean Difference (IV, Random, 95% CI)

‐0.33 [‐1.22, 0.56]

14.1 No depression at onset

2

145

Std. Mean Difference (IV, Random, 95% CI)

‐0.33 [‐1.22, 0.56]

14.2 Depression at onset

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

1 Dependent on modified Rankin score (mRS 3 to 5) Show forest plot

2

223

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.68, 0.97]

1.1 Fluoxetine

1

112

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.68, 0.97]

1.2 Sertraline

1

111

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

2 Disability Show forest plot

7

325

Std. Mean Difference (IV, Random, 95% CI)

0.39 [0.15, 0.63]

2.1 Fluoxetine

6

305

Std. Mean Difference (IV, Random, 95% CI)

0.38 [0.11, 0.66]

2.2 Sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2.3 Citalopram

1

20

Std. Mean Difference (IV, Random, 95% CI)

0.25 [‐0.63, 1.13]

2.4 Paroxetine

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2.5 Escitalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2.6 Sertraline or fluoxetine

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3 Neurological deficit score Show forest plot

10

649

Std. Mean Difference (IV, Random, 95% CI)

‐0.72 [‐1.11, ‐0.33]

3.1 Fluoxetine

5

362

Std. Mean Difference (IV, Random, 95% CI)

‐0.52 [‐0.89, ‐0.15]

3.2 Sertraline

2

108

Std. Mean Difference (IV, Random, 95% CI)

‐0.26 [‐0.96, 0.45]

3.3 Citalopram

3

179

Std. Mean Difference (IV, Random, 95% CI)

‐1.43 [‐2.25, ‐0.60]

3.4 Paroxetine

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3.5 Fluoxetine or sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

4 Depression (continuous data) Show forest plot

10

647

Std. Mean Difference (IV, Random, 95% CI)

‐0.17 [‐0.61, 0.28]

4.1 Fluoxetine

6

374

Std. Mean Difference (IV, Random, 95% CI)

‐0.38 [‐0.91, 0.16]

4.2 Sertraline

3

253

Std. Mean Difference (IV, Random, 95% CI)

0.28 [‐0.63, 1.20]

4.3 Citalopram

1

20

Std. Mean Difference (IV, Random, 95% CI)

‐0.40 [‐1.29, 0.48]

4.4 Paroxetine

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

4.5 Fluoxetine or sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

5 Depression (dichotomous data) Show forest plot

3

283

Risk Ratio (M‐H, Random, 95% CI)

0.50 [0.27, 0.92]

5.1 Fluoxetine

1

67

Risk Ratio (M‐H, Random, 95% CI)

0.26 [0.06, 1.12]

5.2 Sertraline

1

99

Risk Ratio (M‐H, Random, 95% CI)

0.77 [0.34, 1.76]

5.3 Citalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

5.4 Paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

5.5 Escitalopram

1

117

Risk Ratio (M‐H, Random, 95% CI)

0.38 [0.14, 0.99]

6 Anxiety (continuous data) Show forest plot

3

115

Std. Mean Difference (IV, Random, 95% CI)

‐0.40 [‐0.85, 0.05]

6.1 Fluoxetine

3

115

Std. Mean Difference (IV, Random, 95% CI)

‐0.40 [‐0.85, 0.05]

6.2 Sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6.3 Citalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6.4 Paroxetine

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6.5 Escitalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

7 Anxiety (dichotomous data)

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

8 Cognition (continuous scores end of treatment) Show forest plot

4

223

Std. Mean Difference (IV, Random, 95% CI)

0.16 [‐0.18, 0.49]

8.1 Fluoxetine

2

55

Std. Mean Difference (IV, Random, 95% CI)

0.03 [‐0.50, 0.56]

8.2 Sertraline

1

80

Std. Mean Difference (IV, Random, 95% CI)

0.53 [0.08, 0.98]

8.3 Citalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8.4 Escitalopram

1

88

Std. Mean Difference (IV, Random, 95% CI)

‐0.07 [‐0.49, 0.35]

9 Death Show forest plot

13

920

Risk Ratio (M‐H, Random, 95% CI)

1.06 [0.36, 3.09]

9.1 Fluoxetine

7

452

Risk Ratio (M‐H, Random, 95% CI)

0.78 [0.14, 4.39]

9.2 Sertraline

4

331

Risk Ratio (M‐H, Random, 95% CI)

0.91 [0.20, 4.19]

9.3 Citalopram

1

20

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

9.4 Paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

9.5 Escitalopram

1

117

Risk Ratio (M‐H, Random, 95% CI)

4.92 [0.24, 100.25]

9.6 Sertraline or fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10 Seizures Show forest plot

1

118

Risk Ratio (M‐H, Random, 95% CI)

3.0 [0.12, 72.18]

10.1 Fluoxetine

1

118

Risk Ratio (M‐H, Random, 95% CI)

3.0 [0.12, 72.18]

10.2 Sertraline

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.3 Citalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.4 Paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.5 Escitalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.6 Sertraline or fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11 Gastrointestinal side effects Show forest plot

5

363

Risk Ratio (M‐H, Random, 95% CI)

1.92 [0.98, 3.77]

11.1 Fluoxetine

4

335

Risk Ratio (M‐H, Random, 95% CI)

2.09 [1.05, 4.18]

11.2 Sertraline

1

28

Risk Ratio (M‐H, Random, 95% CI)

0.33 [0.01, 7.55]

11.3 Citalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11.4 Paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11.5 Escitalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11.6 Sertraline and paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12 Bleeding

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.1 Fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.2 Sertraline

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.3 Citalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.4 Paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.5 Escitalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.6 Sertraline or fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

13 Change in depression scores between baseline and follow‐up

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

13.1 Sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

14 Change in cognition between baseline and end of treatment Show forest plot

1

99

Std. Mean Difference (IV, Random, 95% CI)

0.0 [‐0.39, 0.39]

14.1 Sertraline

1

99

Std. Mean Difference (IV, Random, 95% CI)

0.0 [‐0.39, 0.39]

15 Leaving the trial before the end of scheduled follow‐up Show forest plot

15

1168

Risk Ratio (M‐H, Random, 95% CI)

0.99 [0.80, 1.23]

15.1 Fluoxetine

8

552

Risk Ratio (M‐H, Random, 95% CI)

1.16 [0.72, 1.89]

15.2 Sertraline

5

479

Risk Ratio (M‐H, Random, 95% CI)

0.95 [0.69, 1.32]

15.3 Citalopram

1

20

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

15.4 Paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

15.5 Sertraline or fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

15.6 Escitalopram

1

117

Risk Ratio (M‐H, Random, 95% CI)

1.38 [0.46, 4.09]

16 Bleeding Show forest plot

1

118

Risk Ratio (M‐H, Random, 95% CI)

1.0 [0.06, 15.61]

1 Dependent on modified Rankin score (mRS 3 to 5) Show forest plot

2

223

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.68, 0.97]

1.1 Fluoxetine

1

112

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.68, 0.97]

1.2 Sertraline

1

111

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

2 Disability Show forest plot

3

115

Std. Mean Difference (IV, Random, 95% CI)

0.70 [‐0.73, 2.13]

2.1 Fluoxetine

2

55

Std. Mean Difference (IV, Random, 95% CI)

0.01 [‐0.54, 0.56]

2.2 Sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2.3 Citalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2.4 Paroxetine

1

60

Std. Mean Difference (IV, Random, 95% CI)

2.04 [1.41, 2.67]

2.5 Escitalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2.6 Sertraline or fluoxetine

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3 Neurological deficit score Show forest plot

4

289

Std. Mean Difference (IV, Random, 95% CI)

‐0.94 [‐1.63, ‐0.26]

3.1 Fluoxetine

3

229

Std. Mean Difference (IV, Random, 95% CI)

‐0.68 [‐1.30, ‐0.06]

3.2 Sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3.3 Citalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3.4 Paroxetine

1

60

Std. Mean Difference (IV, Random, 95% CI)

‐1.76 [‐2.36, ‐1.15]

3.5 Fluoxetine or sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

4 Depression (continuous data) Show forest plot

7

464

Std. Mean Difference (IV, Random, 95% CI)

‐0.72 [‐1.52, 0.07]

4.1 Fluoxetine

4

215

Std. Mean Difference (IV, Random, 95% CI)

‐0.01 [‐0.54, 0.53]

4.2 Sertraline

1

123

Std. Mean Difference (IV, Random, 95% CI)

‐0.16 [‐0.52, 0.19]

4.3 Citalopram

1

66

Std. Mean Difference (IV, Random, 95% CI)

‐0.54 [‐1.04, ‐0.05]

4.4 Paroxetine

1

60

Std. Mean Difference (IV, Random, 95% CI)

‐5.32 [‐6.43, ‐4.21]

4.5 Fluoxetine or sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

5 Depression (dichotomous data) Show forest plot

2

166

Risk Ratio (M‐H, Random, 95% CI)

0.53 [0.19, 1.49]

5.1 Fluoxetine

1

67

Risk Ratio (M‐H, Random, 95% CI)

0.26 [0.06, 1.12]

5.2 Sertraline

1

99

Risk Ratio (M‐H, Random, 95% CI)

0.77 [0.34, 1.76]

5.3 Citalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

5.4 Paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

5.5 Escitalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

6 Anxiety (continuous data) Show forest plot

3

115

Std. Mean Difference (IV, Random, 95% CI)

‐0.66 [‐1.74, 0.42]

6.1 Fluoxetine

2

55

Std. Mean Difference (IV, Random, 95% CI)

‐0.13 [‐0.66, 0.40]

6.2 Sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6.3 Citalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6.4 Paroxetine

1

60

Std. Mean Difference (IV, Random, 95% CI)

‐1.67 [‐2.26, ‐1.08]

6.5 Escitalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

7 Anxiety (dichotomous data)

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

8 Cognition (continuous scores end of treatment) Show forest plot

2

55

Std. Mean Difference (IV, Random, 95% CI)

0.03 [‐0.50, 0.56]

8.1 Fluoxetine

2

55

Std. Mean Difference (IV, Random, 95% CI)

0.03 [‐0.50, 0.56]

8.2 Sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8.3 Citalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8.4 Escitalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

9 Death Show forest plot

9

651

Risk Ratio (M‐H, Random, 95% CI)

0.87 [0.30, 2.50]

9.1 Fluoxetine

5

302

Risk Ratio (M‐H, Random, 95% CI)

0.78 [0.14, 4.39]

9.2 Sertraline

2

223

Risk Ratio (M‐H, Random, 95% CI)

0.79 [0.08, 8.19]

9.3 Citalopram

1

66

Risk Ratio (M‐H, Random, 95% CI)

1.0 [0.15, 6.68]

9.4 Paroxetine

1

60

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

9.5 Escitalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

9.6 Sertraline or fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10 Seizures Show forest plot

3

244

Risk Ratio (M‐H, Random, 95% CI)

3.93 [0.44, 34.85]

10.1 Fluoxetine

1

118

Risk Ratio (M‐H, Random, 95% CI)

3.0 [0.12, 72.18]

10.2 Sertraline

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.3 Citalopram

1

66

Risk Ratio (M‐H, Random, 95% CI)

5.0 [0.25, 100.32]

10.4 Paroxetine

1

60

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.5 Escitalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.6 Sertraline or fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11 Gastrointestinal side effects Show forest plot

2

178

Risk Ratio (M‐H, Random, 95% CI)

2.48 [1.06, 5.80]

11.1 Fluoxetine

1

118

Risk Ratio (M‐H, Random, 95% CI)

2.33 [0.96, 5.66]

11.2 Sertraline

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11.3 Citalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11.4 Paroxetine

1

60

Risk Ratio (M‐H, Random, 95% CI)

5.0 [0.25, 99.95]

11.5 Escitalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11.6 Sertraline and paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12 Bleeding

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.1 Fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.2 Sertraline

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.3 Citalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.4 Paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.5 Escitalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.6 Sertraline or fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

13 Change in depression scores between baseline and follow‐up

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

13.1 Sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

14 Change in cognition between baseline and end of treatment Show forest plot

1

99

Std. Mean Difference (IV, Random, 95% CI)

0.0 [‐0.39, 0.39]

14.1 Sertraline

1

99

Std. Mean Difference (IV, Random, 95% CI)

0.0 [‐0.39, 0.39]

15 Leaving the trial before the end of scheduled follow‐up Show forest plot

9

673

Risk Ratio (M‐H, Random, 95% CI)

1.21 [0.75, 1.95]

15.1 Fluoxetine

5

312

Risk Ratio (M‐H, Random, 95% CI)

1.11 [0.58, 2.11]

15.2 Sertraline

2

234

Risk Ratio (M‐H, Random, 95% CI)

1.10 [0.47, 2.54]

15.3 Citalopram

1

66

Risk Ratio (M‐H, Random, 95% CI)

6.00 [0.76, 47.14]

15.4 Paroxetine

1

61

Risk Ratio (M‐H, Random, 95% CI)

3.10 [0.13, 73.16]

15.5 Sertraline or fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

15.6 Escitalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

16 Bleeding

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

1 Dependent on modified Rankin score (mRS 3 to 5) Show forest plot

2

223

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.68, 0.97]

1.1 Fluoxetine

1

112

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.68, 0.97]

1.2 Sertraline

1

111

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

2 Disability Show forest plot

7

297

Std. Mean Difference (IV, Random, 95% CI)

0.36 [0.12, 0.59]

2.1 Fluoxetine

6

277

Std. Mean Difference (IV, Random, 95% CI)

0.35 [0.08, 0.61]

2.2 Sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2.3 Citalopram

1

20

Std. Mean Difference (IV, Random, 95% CI)

0.25 [‐0.63, 1.13]

2.4 Paroxetine

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2.5 Escitalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2.6 Sertraline or fluoxetine

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3 Neurological deficit score Show forest plot

6

315

Std. Mean Difference (IV, Random, 95% CI)

‐0.32 [‐0.55, ‐0.10]

3.1 Fluoxetine

4

267

Std. Mean Difference (IV, Random, 95% CI)

‐0.35 [‐0.59, ‐0.11]

3.2 Sertraline

1

28

Std. Mean Difference (IV, Random, 95% CI)

0.17 [‐0.57, 0.91]

3.3 Citalopram

1

20

Std. Mean Difference (IV, Random, 95% CI)

‐0.68 [‐1.59, 0.23]

3.4 Paroxetine

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3.5 Fluoxetine or sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

4 Depression (continuous data) Show forest plot

11

646

Std. Mean Difference (IV, Random, 95% CI)

‐0.40 [‐0.71, ‐0.09]

4.1 Fluoxetine

8

437

Std. Mean Difference (IV, Random, 95% CI)

‐0.40 [‐0.83, 0.03]

4.2 Sertraline

1

123

Std. Mean Difference (IV, Random, 95% CI)

‐0.16 [‐0.52, 0.19]

4.3 Citalopram

2

86

Std. Mean Difference (IV, Random, 95% CI)

‐0.51 [‐0.94, ‐0.08]

4.4 Paroxetine

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

4.5 Fluoxetine or sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

5 Depression (dichotomous data) Show forest plot

3

283

Risk Ratio (M‐H, Random, 95% CI)

0.52 [0.30, 0.90]

5.1 Fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

5.2 Sertraline

2

166

Risk Ratio (M‐H, Random, 95% CI)

0.59 [0.28, 1.25]

5.3 Citalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

5.4 Paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

5.5 Escitalopram

1

117

Risk Ratio (M‐H, Random, 95% CI)

0.38 [0.14, 0.99]

6 Anxiety (continuous data) Show forest plot

2

55

Std. Mean Difference (IV, Random, 95% CI)

‐0.13 [‐0.66, 0.40]

6.1 Fluoxetine

2

55

Std. Mean Difference (IV, Random, 95% CI)

‐0.13 [‐0.66, 0.40]

6.2 Sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6.3 Citalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6.4 Paroxetine

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6.5 Escitalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

7 Anxiety (dichotomous data)

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

8 Cognition (continuous scores end of treatment) Show forest plot

4

174

Std. Mean Difference (IV, Random, 95% CI)

‐0.10 [‐0.39, 0.20]

8.1 Fluoxetine

3

86

Std. Mean Difference (IV, Random, 95% CI)

‐0.12 [‐0.55, 0.30]

8.2 Sertraline

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8.3 Citalopram

0

0

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8.4 Escitalopram

1

88

Std. Mean Difference (IV, Random, 95% CI)

‐0.07 [‐0.49, 0.35]

9 Death Show forest plot

14

865

Risk Ratio (M‐H, Random, 95% CI)

1.05 [0.41, 2.66]

9.1 Fluoxetine

8

411

Risk Ratio (M‐H, Random, 95% CI)

0.78 [0.14, 4.39]

9.2 Sertraline

3

251

Risk Ratio (M‐H, Random, 95% CI)

0.91 [0.20, 4.19]

9.3 Citalopram

2

86

Risk Ratio (M‐H, Random, 95% CI)

1.0 [0.15, 6.68]

9.4 Paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

9.5 Escitalopram

1

117

Risk Ratio (M‐H, Random, 95% CI)

4.92 [0.24, 100.25]

9.6 Sertraline or fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10 Seizures Show forest plot

4

250

Risk Ratio (M‐H, Random, 95% CI)

2.67 [0.61, 11.63]

10.1 Fluoxetine

3

184

Risk Ratio (M‐H, Random, 95% CI)

2.19 [0.41, 11.85]

10.2 Sertraline

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.3 Citalopram

1

66

Risk Ratio (M‐H, Random, 95% CI)

5.0 [0.25, 100.32]

10.4 Paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.5 Escitalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

10.6 Sertraline or fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11 Gastrointestinal side effects Show forest plot

5

303

Risk Ratio (M‐H, Random, 95% CI)

1.37 [0.63, 2.98]

11.1 Fluoxetine

4

275

Risk Ratio (M‐H, Random, 95% CI)

1.48 [0.65, 3.39]

11.2 Sertraline

1

28

Risk Ratio (M‐H, Random, 95% CI)

0.33 [0.01, 7.55]

11.3 Citalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11.4 Paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11.5 Escitalopram

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

11.6 Sertraline and paroxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12 Bleeding

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.1 Fluoxetine

0

0

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

12.2 Sertraline

0

0

Risk Ratio (M‐H, Random, 95% CI)