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Cochrane Database of Systematic Reviews

Corticosteroide y agonista beta 2 de acción prolongada combinados en un inhalador versus agonistas beta2 de acción prolongada para la enfermedad pulmonar obstructiva crónica

Información

DOI:
https://doi.org/10.1002/14651858.CD006829.pub2Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 12 septiembre 2012see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:
  1. Grupo Cochrane de Vías respiratorias

Copyright:
  1. Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Autores

  • Luis Javier Nannini

    Correspondencia a: Pulmonary Section, Hospital E Peron, G. Baigorria, Argentina

    [email protected]

  • Toby J Lasserson

    Cochrane Editorial Unit, The Cochrane Collaboration, London, UK

  • Phillippa Poole

    Department of Medicine, University of Auckland, Auckland, New Zealand

Contributions of authors

LN and PP developed the protocol. Studies were assessed by LN and TJL. TJL and LN checked data and entered data into RevMan. TJL and LN conducted the analysis. TJL and LN developed the discussion with input from PP. PP assisted with the write‐up of the 2012 update.

Sources of support

Internal sources

  • NHS Cochrane Grant scheme, UK.

External sources

  • No sources of support supplied

Declarations of interest

The authors who have been involved in this review have done so without any known conflicts of interest. None of the authors are considered a paid consultant by any pharmaceutical company which produces agents discussed in this review.

Acknowledgements

The authors are indebted to the Hamamellis Trust who very generously funded the return travel to London for Dr Nannini to spend a week working on the development of the first review. Thanks to Liz Stovold, Susan Hansen, Karen Blackhall, Jo Picot and Sarah Tracy for technical and clerical support. We are grateful to Karla Soares‐Weiser who extracted data in duplicate for the 2011 update of this review and to Chris Cates for statistical advice and input with calculating SEMs for the included studies for use in GIV analyses.

We would also like to acknowledge the efforts of Inge Vestbo, Diane Grimley and Karen Richardson of GSK who helped us in our attempts to obtain unpublished information on TRISTAN, and of Goran Tornling, Moira Coughlan and Roger Metcalf of AstraZeneca in helping us obtain data for Szafranski 2003. We thank Dr Nick Hanania, Dr Peter Kardos and Prof Donald Mahler for corresponding with us in our attempts to obtain unpublished data from their studies, Dr Dal Negro (Dal Negro 2003) for confirming the SDs in his study and Dr Anzueto for confirming that Ferguson 2008 and Anzueto 2009 are replicate trials.

CRG Funding Acknowledgement: The National Institute for Health Research (NIHR) is the largest single funder of the Cochrane Airways Group.

Disclaimer: The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the NIHR, NHS or the Department of Health.

Version history

Published

Title

Stage

Authors

Version

2012 Sep 12

Combined corticosteroid and long‐acting beta<sub>2</sub>‐agonist in one inhaler versus long‐acting beta<sub>2</sub>‐agonists for chronic obstructive pulmonary disease

Review

Luis Javier Nannini, Toby J Lasserson, Phillippa Poole

https://doi.org/10.1002/14651858.CD006829.pub2

2007 Oct 17

Combined corticosteroid and long‐acting beta‐agonist in one inhaler versus long‐acting beta‐agonists for chronic obstructive pulmonary disease

Review

Luis Javier Nannini, Christopher J Cates, Toby J Lasserson, Phillippa Poole

https://doi.org/10.1002/14651858.CD006829

Differences between protocol and review

We updated the risk of bias assessment, adding an evaluation of incomplete outcome data which was stratified by outcome. In view of the clinical heterogeneity between the studies and the statistical heterogeneity, the 2012 update has reported the results of random‐effects models throughout (with a fixed‐effect model for sensitivity analysis).

We removed subgroups based on reversibility from the forest plots for the 2012 review.

The GIV method was not available when the protocol was developed.

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.