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Cochrane Database of Systematic Reviews

Polymer‐based oral rehydration solution for treating acute watery diarrhoea

Esta versión no es la más reciente

Información

DOI:
https://doi.org/10.1002/14651858.CD006519.pub2Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 14 abril 2009see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:
  1. Grupo Cochrane de Enfermedades infecciosas

Copyright:
  1. Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Contraer

Autores

  • Germana V Gregorio

    Correspondencia a: Department of Pediatrics, College of Medicine‐Philippine General Hospital, University of the Philippines, Manila, Philippines

    [email protected]

  • Maria Liza M Gonzales

    Department of Pediatrics, College of Medicine‐Philippine General Hospital, University of the Philippines, Manila, Philippines

  • Leonila F Dans

    Departments of Pediatrics and Clinical Epidemiology, Philippine General Hospital, University of the Philippines, Manila, Philippines

  • Elizabeth G Martinez

    Department of Pediatrics, College of Medicine‐Philippine General Hospital, University of the Philippines, Manila, Philippines

Contributions of authors

GV Gregorio was the principal investigator, wrote the protocol, carried out the risk of bias (methodological quality) assessment, data extraction and analysis, and wrote the final manuscript.

MLM Gonzales helped in writing the protocol, carried out the risk of bias (methodological quality) assessment and data extraction, and commented on the final manuscript.

LF Dans carried out the risk of bias (methodological quality) assessment.

EG Martinez carried out the data extraction and commented on the final manuscript.

Sources of support

Internal sources

  • Effective Health Care Research Programme Consortium, UK.

External sources

  • Department for International Development (DFID), UK.

Declarations of interest

None known.

Acknowledgements

This document is an output from a project funded by the UK Department for International Development (DFID) for the benefit of developing countries. The views expressed are not necessarily those of DFID.

Version history

Published

Title

Stage

Authors

Version

2016 Dec 13

Polymer‐based oral rehydration solution for treating acute watery diarrhoea

Review

Germana V Gregorio, Maria Liza M Gonzales, Leonila F Dans, Elizabeth G Martinez

https://doi.org/10.1002/14651858.CD006519.pub3

2009 Apr 14

Polymer‐based oral rehydration solution for treating acute watery diarrhoea

Review

Germana V Gregorio, Maria Liza M Gonzales, Leonila F Dans, Elizabeth G Martinez

https://doi.org/10.1002/14651858.CD006519.pub2

2007 Apr 18

Glucose polymer‐based oral rehydration solution for treating acute watery diarrhoea

Protocol

Germana V Gregorio, Maria Liza M Gonzales, Leonila F Dans, Elizabeth G Martinez

https://doi.org/10.1002/14651858.CD006519

Differences between protocol and review

  • Change in title: The title was changed to highlight the fact that this is a review of polymer‐based ORS (not glucose‐based ORS).

  • New author: EG Martinez joined the author team after the protocol was published.

  • Data extraction: We originally planned to extract count data by determining the total number of episodes in each group (if the episode is rare) or the number of person years in each group for each treatment arm (if the episode is common). However, during the assessment of the trials, the trials reported the number of participants with unscheduled use of intravenous fluid, and thus it was considered to be a dichotomous rather than a count outcome. Similarly, in the data extraction for number of episodes of vomiting, there were only four trials that reported this outcome, while nine clinical trials reported the number of participants with vomiting. It was decided that the latter would be reported. Other adverse effects that were reported in the trials, including number of participants with hypokalaemia (low potassium levels) and those with development of persistent diarrhoea (diarrhoea of more than 10 days' duration from onset), were also included in the review.

  • Data analysis: In multiple treatment arms with two or more polymer‐based ORS as treatment groups, the outcomes were combined as appropriate and compared collectively with the control group. Most of the trials included both cholera and non‐cholera cases, and this group was collectively termed as having mixed pathogens rather than non‐cholera related diarrhoea.

  • Subgroup analyses: These were limited to the osmolarity of the glucose ORS, the type of polymer, and the effects of participant's age and pathogen. The source of the polymer and the effect of feeding were no longer evaluated as most of the polymers were locally prepared and all but two trials withheld feeding after hydration.

  • Publication bias: The presence of publication bias was confirmed with StatsDirect, a statistical software program.

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.