Cardiac toxicity

Left ventricular ejection fraction (LVEF) abnormal by multiple‐gated acquisition (MUGA) or echocardiogram

Uncontrolled arterial hypertension

Myocardial infarction

Unstable angina or angina pectoris

Congestive heart failure

Serious cardiac arrhythmia

QTc interval greater than 440 msec

Rhythm abnormalities requiring permanent therapy

Prolonged PR interval or atrioventricular block on electrocardiogram (ECG)

Second or third‐degree heart blocks

Peripheral vascular disease

Cardiomyopathy

Signs and symptoms of cardiac dysfunction (such as dyspnea, increased cough, paroxysmal nocturnal dyspnea, peripheral edema)

Other clinically significant cardiovascular disease