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Cochrane Database of Systematic Reviews

Trastuzumab containing regimens for early breast cancer

Esta versión no es la más reciente

ver la versión actual 18 abril 2012

Información

DOI:
https://doi.org/10.1002/14651858.CD006243Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 18 octubre 2006see what's new
Tipo:
  1. Intervention
Etapa:
  1. Protocol
Grupo Editorial Cochrane:

  1. Grupo Cochrane de Cáncer de mama

Copyright:
  1. Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Contraer

Autores

  • Lorenzo Moja

    Correspondencia a: Centro Cochrane Italiano, Istituto Mario Negri, Milano, Italy

    [email protected]

  • Cinzia Brambilla

    Italian Cochrane Centre, Mario Negri Institute, Milan, Italy

  • Anna Compagnoni

    Laboratorio per la Ricerca Clinica Oncologica, Instituto Mario Negri, Milan, Italy

  • Vanna Pistotti

    Centro Cochrane Italiano, Milano, Italy

Contributions of authors

Lorenzo Moja (LPM), Anna Compagnoni (AC) and Cinzia Brambilla (CB) conceived the study and participated in developing the protocol. LPM and AC developed the search strategies and the quality assessment for observational studies. Vanna Pistotti (VP) revised all the search strategies.

Sources of support

Internal sources

  • Mario Negri Institute, Italy.

External sources

  • No sources of support supplied

Declarations of interest

None known.

Acknowledgements

The authors gratefully acknowledge Su Golder and Carol Lefebvre for valuable suggestions about bibliographic researches; Deirdre Price, Jessica Thomas and Andrew Herxheimer for valuable suggestions about methodological issues in analysing adverse events; Davina Ghersi, Sharon Parker, Nancy Owens and Nicholas Wilcken for their helpful assistance during all the phases of the preparation of the protocol.

Version history

Published

Title

Stage

Authors

Version

2012 Apr 18

Trastuzumab containing regimens for early breast cancer

Review

Lorenzo Moja, Ludovica Tagliabue, Sara Balduzzi, Elena Parmelli, Vanna Pistotti, Valentina Guarneri, Roberto D'Amico

https://doi.org/10.1002/14651858.CD006243.pub2

2006 Oct 18

Trastuzumab containing regimens for early breast cancer

Protocol

Lorenzo Moja, Cinzia Brambilla, Anna Compagnoni, Vanna Pistotti

https://doi.org/10.1002/14651858.CD006243

Keywords

MeSH

Medical Subject Headings (MeSH) Keywords

Medical Subject Headings Check Words

Female; Humans;

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.

Table 1. Potential list of cardiac adverse events

Cardiac toxicity

Left ventricular ejection fraction (LVEF) abnormal by multiple‐gated acquisition (MUGA) or echocardiogram

Uncontrolled arterial hypertension

Myocardial infarction

Unstable angina or angina pectoris

Congestive heart failure

Serious cardiac arrhythmia

QTc interval greater than 440 msec

Rhythm abnormalities requiring permanent therapy

Prolonged PR interval or atrioventricular block on electrocardiogram (ECG)

Second or third‐degree heart blocks

Peripheral vascular disease

Cardiomyopathy

Signs and symptoms of cardiac dysfunction (such as dyspnea, increased cough, paroxysmal nocturnal dyspnea, peripheral edema)

Other clinically significant cardiovascular disease
Figuras y tablas -
Table 1. Potential list of cardiac adverse events
Ir a la tabla del protocolo