Corticosteroid interventions for treating nerve damage in leprosy
Información
- DOI:
- https://doi.org/10.1002/14651858.CD005491Copiar DOI
- Base de datos:
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- Cochrane Database of Systematic Reviews
- Versión publicada:
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- 19 octubre 2005see what's new
- Tipo:
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- Intervention
- Etapa:
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- Protocol
- Grupo Editorial Cochrane:
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Grupo Cochrane de Neuromuscular
- Copyright:
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- Copyright © 2007 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Cifras del artículo
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Autores
Contributions of authors
Link with editorial base and co‐ordinate contributions from co‐reviewers (NVV)
Draft protocol (NVV, with input from all)
Run search (NVV)
Identify relevant titles and abstracts from searches (NVV, JHR)
Obtain copies of trials (NVV)
Selection of trials (NVV, JHR)
Extract data from trials (NVV, JHR)
Enter data into RevMan (NVV)
Carry out analysis (NVV)
Interpret data (NVV, with input from all)
Draft final review (NVV, with input from all)
Update review (NVV)
Sources of support
Internal sources
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No sources of support supplied
External sources
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Netherlands Leprosy Relief, Netherlands.
Declarations of interest
PN was involved in a RCT (INFIR 2) comparing azathioprine and prednisolone in the treatment of severe leprosy type 1 reactions.
PN, JHR and WCS were involved in a series of RCTs (TRIPOD) examining the effect of treatment with corticosteroids for nerve function impairment in leprosy.
Version history
| Published | Title | Stage | Authors | Version |
| 2016 May 23 | Corticosteroids for treating nerve damage in leprosy | Review | Natasja HJ Van Veen, Peter G Nicholls, W Cairns S Smith, Jan Hendrik Richardus | |
| 2007 Apr 18 | Corticosteroids for treating nerve damage in leprosy | Review | Natasja HJ Van Veen, Peter G Nicholls, W Cairns S Smith, Jan Hendrik Richardus | |
| 2005 Oct 19 | Corticosteroid interventions for treating nerve damage in leprosy | Protocol | Natasja HJ Van Veen, Albert Meima, Peter G. Nicholls, W Cairns S Smith, Jan Hendrik Richardus | |
Keywords
MeSH
Medical Subject Headings (MeSH) Keywords
- Glucocorticoids [administration & dosage, adverse effects, *therapeutic use];
- Leprosy [*complications];
- Methylprednisolone [therapeutic use];
- Peripheral Nervous System Diseases [diagnosis, *drug therapy, etiology];
- Prednisolone [administration & dosage, therapeutic use];
- Randomized Controlled Trials as Topic;
- Somatosensory Disorders [diagnosis, *drug therapy, etiology];
Medical Subject Headings Check Words
Humans;
PICO
| Ridley‐Jopling | WHO |
| TT: tuberculoid leprosy | PB: paucibacillary leprosy |
| BT: borderline tuberculoid leprosy | PB |
| BB: borderline leprosy | MB: multibacillary leprosy |
| BL: borderline lepromatous leprosy | MB |
| LL: lepromatous leprosy | MB |
| Colour | Approximate force | Score for hand | Score for foot |
| blue filament felt | 200 mg | 0 | ‐ |
| purple filament felt | 2 g | 1 | 0 |
| red filament felt | 4 g | 2 | 1 |
| orange filament felt | 10 g | 3 | 2 |
| pink filament felt | 300 g | 4 | 3 |
| pink filament not felt | ‐ | 5 | 4 |
| Grade | Definition |
| 5 | Full range of movement of the joint on which the muscle or muscle group is acting. Normal resistance can be given. |
| 4 | Full range of movement but less than normal resistance. |
| 3 | Full range of movement but no resistance. |
| 2 | Partial range of movement with no resistance. |
| 1 | Perceptible contraction of the muscle(s) not resulting in joint movement. |
| 0 | Complete paralysis. |
| 3‐point scale | 4‐point scale | MRC scale |
| strong | strong | 5 |
| weak | resistance reduced / movement reduced | 4,3 / 2 |
| paralysis | paralysis | 1,0 |
| Score | Grade |
| Nerve pain | |
| 3 | absent |
| 2 | mild (only aware intermittently and does not limit activity) |
| 1 | moderate (sleep disturbed, activities diminished, work efficiency diminished) |
| 0 | severe (incapacitating) |
| Nerve tenderness | |
| 3 | absent |
| 2 | mild (absent if patients' attention is distracted) |
| 1 | moderate (present if attention is distracted) |
| 0 | severe (very tender and patient withdraws the arm forcibly) |
| Search terms |
| 'mp' denotes keyword search in title, abstract |
