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Corticosteroid interventions for treating nerve damage in leprosy

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Table 1. Leprosy classification ‐ Ridley Jopling WHO

Ridley‐Jopling

WHO

TT: tuberculoid leprosy

PB: paucibacillary leprosy

BT: borderline tuberculoid leprosy

PB

BB: borderline leprosy

MB: multibacillary leprosy

BL: borderline lepromatous leprosy

MB

LL: lepromatous leprosy

MB

Figuras y tablas -
Table 1. Leprosy classification ‐ Ridley Jopling WHO
Table 2. Sensory scoring system ‐ Van Brakel et al.

Colour

Approximate force

Score for hand

Score for foot

blue filament felt

200 mg

0

purple filament felt

2 g

1

0

red filament felt

4 g

2

1

orange filament felt

10 g

3

2

pink filament felt

300 g

4

3

pink filament not felt

5

4

Figuras y tablas -
Table 2. Sensory scoring system ‐ Van Brakel et al.
Table 3. Modified MRC scale ‐ Brandsma

Grade

Definition

5

Full range of movement of the joint on which the muscle or muscle group is acting. Normal resistance can be given.

4

Full range of movement but less than normal resistance.

3

Full range of movement but no resistance.

2

Partial range of movement with no resistance.

1

Perceptible contraction of the muscle(s) not resulting in joint movement.

0

Complete paralysis.

Figuras y tablas -
Table 3. Modified MRC scale ‐ Brandsma
Table 4. Voluntary muscle testing: transformation to a 3‐point scale

3‐point scale

4‐point scale

MRC scale

strong

strong

5

weak

resistance reduced / movement reduced

4,3 / 2

paralysis

paralysis

1,0

Figuras y tablas -
Table 4. Voluntary muscle testing: transformation to a 3‐point scale
Table 5. Scoring system for nerve pain and tenderness ‐ Pearson

Score

Grade

Nerve pain

3

absent

2

mild (only aware intermittently and does not limit activity)

1

moderate (sleep disturbed, activities diminished, work efficiency diminished)

0

severe (incapacitating)

Nerve tenderness

3

absent

2

mild (absent if patients' attention is distracted)

1

moderate (present if attention is distracted)

0

severe (very tender and patient withdraws the arm forcibly)

Figuras y tablas -
Table 5. Scoring system for nerve pain and tenderness ‐ Pearson
Table 6. Medline search strategy

Search terms

'mp' denotes keyword search in title, abstract
'tw' denotes keyword search in text word
'*' denotes truncation
'exp' denotes explosion of mesh subject heading

Search strategy to identify RCTs
search terms 1‐29, as given in the Cochrane Reviewers' Handbook (Alderson 2004), appendix 5b.2.

Search strategy to identify relevant studies
30.exp leprosy
31.hansen* disease.tw
32.leprosy.tw
33.or/30‐32
34.steroid*.mp
35.glucocorticoid*.mp
36.corticosteroid*.mp
37.prednisolon*.mp
38.prednison*.mp
39.cortison*.mp
40.cortical hormone*.mp
41.cyclosporin A.mp
42.azathioprin*.mp
43.methylprednisolon*.mp
44.betamethason*.mp
45.or/34‐44
46.exp decompression, surgical
47.decompression.mp
48.neurolysis.mp
49.epicondylectomy.mp
50.or/46‐49
51.exp peripheral nervous system diseases
52.neuritis.mp
53.neuropath*.mp
54.nerve damage.mp
55.nerve involvement.mp
56.nerve loss.mp
57.nerve function impairment.mp
58.nerve problem*.mp
59.sensory loss.mp
60.motor loss.mp
61.motor function loss.mp
62.nerve pain.mp
63.nerve tenderness.mp
64.reaction*.mp
65.reversal reaction.mp
66.type 1 reaction*.mp
67.type 2 reaction*.mp
68.erythema nodosum leprosum.mp
69.or/51‐68
70.29 AND 33 AND (45 OR 50) AND 69

This is a draft search strategy and subject to necessary changes.

Figuras y tablas -
Table 6. Medline search strategy