Scolaris Content Display Scolaris Content Display

Cochrane Database of Systematic Reviews

Corticosteroid interventions for treating nerve damage in leprosy

This is not the most recent version

Information

DOI:
https://doi.org/10.1002/14651858.CD005491Copy DOI
Database:
  1. Cochrane Database of Systematic Reviews
Version published:
  1. 19 October 2005see what's new
Type:
  1. Intervention
Stage:
  1. Protocol
Cochrane Editorial Group:
  1. Cochrane Neuromuscular Group

Copyright:
  1. Copyright © 2007 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Article metrics

Altmetric:

Cited by:

Cited 0 times via Crossref Cited-by Linking

Collapse

Authors

  • Natasja HJ Van Veen

    Correspondence to: Department of Public Health, Erasmus MC, University Medical Center, Rotterdam, Netherlands

    [email protected]

  • Albert Meima

    Public Health, Erasmus MC, University Medical Center, Rotterdam, Netherlands

  • Peter G. Nicholls

    Department of Public Health, University of Aberdeen, Aberdeen, UK

  • W Cairns S Smith

    Public Health, University of Aberdeen, Aberdeen, UK

  • Jan Hendrik Richardus

    Public Health, Erasmus MC, University Medical Center, Rotterdam, Netherlands

Contributions of authors

Link with editorial base and co‐ordinate contributions from co‐reviewers (NVV)
Draft protocol (NVV, with input from all)
Run search (NVV)
Identify relevant titles and abstracts from searches (NVV, JHR)
Obtain copies of trials (NVV)
Selection of trials (NVV, JHR)
Extract data from trials (NVV, JHR)
Enter data into RevMan (NVV)
Carry out analysis (NVV)
Interpret data (NVV, with input from all)
Draft final review (NVV, with input from all)
Update review (NVV)

Sources of support

Internal sources

  • No sources of support supplied

External sources

  • Netherlands Leprosy Relief, Netherlands.

Declarations of interest

PN was involved in a RCT (INFIR 2) comparing azathioprine and prednisolone in the treatment of severe leprosy type 1 reactions.
PN, JHR and WCS were involved in a series of RCTs (TRIPOD) examining the effect of treatment with corticosteroids for nerve function impairment in leprosy.

Version history

Published

Title

Stage

Authors

Version

2016 May 23

Corticosteroids for treating nerve damage in leprosy

Review

Natasja HJ Van Veen, Peter G Nicholls, W Cairns S Smith, Jan Hendrik Richardus

https://doi.org/10.1002/14651858.CD005491.pub3

2007 Apr 18

Corticosteroids for treating nerve damage in leprosy

Review

Natasja HJ Van Veen, Peter G Nicholls, W Cairns S Smith, Jan Hendrik Richardus

https://doi.org/10.1002/14651858.CD005491.pub2

2005 Oct 19

Corticosteroid interventions for treating nerve damage in leprosy

Protocol

Natasja HJ Van Veen, Albert Meima, Peter G. Nicholls, W Cairns S Smith, Jan Hendrik Richardus

https://doi.org/10.1002/14651858.CD005491

Keywords

MeSH

PICOs

Population
Intervention
Comparison
Outcome

The PICO model is widely used and taught in evidence-based health care as a strategy for formulating questions and search strategies and for characterizing clinical studies or meta-analyses. PICO stands for four different potential components of a clinical question: Patient, Population or Problem; Intervention; Comparison; Outcome.

See more on using PICO in the Cochrane Handbook.

Table 1. Leprosy classification ‐ Ridley Jopling WHO

Ridley‐Jopling

WHO

TT: tuberculoid leprosy

PB: paucibacillary leprosy

BT: borderline tuberculoid leprosy

PB

BB: borderline leprosy

MB: multibacillary leprosy

BL: borderline lepromatous leprosy

MB

LL: lepromatous leprosy

MB

Figures and Tables -
Table 1. Leprosy classification ‐ Ridley Jopling WHO
Table 2. Sensory scoring system ‐ Van Brakel et al.

Colour

Approximate force

Score for hand

Score for foot

blue filament felt

200 mg

0

purple filament felt

2 g

1

0

red filament felt

4 g

2

1

orange filament felt

10 g

3

2

pink filament felt

300 g

4

3

pink filament not felt

5

4

Figures and Tables -
Table 2. Sensory scoring system ‐ Van Brakel et al.
Table 3. Modified MRC scale ‐ Brandsma

Grade

Definition

5

Full range of movement of the joint on which the muscle or muscle group is acting. Normal resistance can be given.

4

Full range of movement but less than normal resistance.

3

Full range of movement but no resistance.

2

Partial range of movement with no resistance.

1

Perceptible contraction of the muscle(s) not resulting in joint movement.

0

Complete paralysis.

Figures and Tables -
Table 3. Modified MRC scale ‐ Brandsma
Table 4. Voluntary muscle testing: transformation to a 3‐point scale

3‐point scale

4‐point scale

MRC scale

strong

strong

5

weak

resistance reduced / movement reduced

4,3 / 2

paralysis

paralysis

1,0

Figures and Tables -
Table 4. Voluntary muscle testing: transformation to a 3‐point scale
Table 5. Scoring system for nerve pain and tenderness ‐ Pearson

Score

Grade

Nerve pain

3

absent

2

mild (only aware intermittently and does not limit activity)

1

moderate (sleep disturbed, activities diminished, work efficiency diminished)

0

severe (incapacitating)

Nerve tenderness

3

absent

2

mild (absent if patients' attention is distracted)

1

moderate (present if attention is distracted)

0

severe (very tender and patient withdraws the arm forcibly)

Figures and Tables -
Table 5. Scoring system for nerve pain and tenderness ‐ Pearson
Table 6. Medline search strategy

Search terms

'mp' denotes keyword search in title, abstract
'tw' denotes keyword search in text word
'*' denotes truncation
'exp' denotes explosion of mesh subject heading

Search strategy to identify RCTs
search terms 1‐29, as given in the Cochrane Reviewers' Handbook (Alderson 2004), appendix 5b.2.

Search strategy to identify relevant studies
30.exp leprosy
31.hansen* disease.tw
32.leprosy.tw
33.or/30‐32
34.steroid*.mp
35.glucocorticoid*.mp
36.corticosteroid*.mp
37.prednisolon*.mp
38.prednison*.mp
39.cortison*.mp
40.cortical hormone*.mp
41.cyclosporin A.mp
42.azathioprin*.mp
43.methylprednisolon*.mp
44.betamethason*.mp
45.or/34‐44
46.exp decompression, surgical
47.decompression.mp
48.neurolysis.mp
49.epicondylectomy.mp
50.or/46‐49
51.exp peripheral nervous system diseases
52.neuritis.mp
53.neuropath*.mp
54.nerve damage.mp
55.nerve involvement.mp
56.nerve loss.mp
57.nerve function impairment.mp
58.nerve problem*.mp
59.sensory loss.mp
60.motor loss.mp
61.motor function loss.mp
62.nerve pain.mp
63.nerve tenderness.mp
64.reaction*.mp
65.reversal reaction.mp
66.type 1 reaction*.mp
67.type 2 reaction*.mp
68.erythema nodosum leprosum.mp
69.or/51‐68
70.29 AND 33 AND (45 OR 50) AND 69

This is a draft search strategy and subject to necessary changes.

Figures and Tables -
Table 6. Medline search strategy