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Quimioterapia adyuvante para el cáncer de pulmón de células no pequeñas en estadio inicial resecado
Sarah Burdett, Jean Pierre Pignon, Jayne Tierney, Helene Tribodet, Lesley Stewart, Cecile Le Pechoux, Anne Aupérin, Thierry Le Chevalier, Richard J Stephens, Rodrigo Arriagada, Julian PT Higgins, David H Johnson, Jan Van Meerbeeck, Mahesh KB Parmar, Robert L Souhami, Bengt Bergman, Jean‐Yves Douillard, Ariane Dunant, Chiaki Endo, David Girling, Harubumi Kato, Steven M Keller, Hideki Kimura, Aija Knuuttila, Ken Kodama, Ritsuko Komaki, Mark G Kris, Thomas Lad, Tommaso Mineo, Steven Piantadosi, Rafael Rosell, Giorgio Scagliotti, Lesley K Seymour, Frances A Shepherd, Richard Sylvester, Hirohito Tada, Fumihiro Tanaka, Valter Torri, David Waller, Ying Liang, for the Non‐Small Cell Lung Cancer Collaborative Group | 2 marzo 2015

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Temas

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Figuras y tablas -
Figure 1

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

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Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 2

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

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Forest plot of comparison: 5 Cause of death, outcome: 5.1 Fatal massive hemoptysis (EBRT +EBB) vs EBRT.
Figuras y tablas -
Figure 3

Forest plot of comparison: 5 Cause of death, outcome: 5.1 Fatal massive hemoptysis (EBRT +EBB) vs EBRT.

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Forest plot of comparison: 3 Response rate of dyspnea, outcome: 3.1 Response of dyspnea EBRT + EBB vs EBRT.
Figuras y tablas -
Figure 4

Forest plot of comparison: 3 Response rate of dyspnea, outcome: 3.1 Response of dyspnea EBRT + EBB vs EBRT.

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Forest plot of comparison: 8 Survival rate, outcome: 8.3 One year survival (EBB vs EBRT ).
Figuras y tablas -
Figure 5

Forest plot of comparison: 8 Survival rate, outcome: 8.3 One year survival (EBB vs EBRT ).

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Comparison 1 Compliance to treatment, Outcome 1 Compliance to treatment EBRT vs EBRT + EBB.
Figuras y tablas -
Analysis 1.1

Comparison 1 Compliance to treatment, Outcome 1 Compliance to treatment EBRT vs EBRT + EBB.

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Comparison 2 Radiological re‐expansion in patients with an atelectasis before RT, Outcome 1 Radiological re‐expansion EBRT + EBB vs EBRT + EBB.
Figuras y tablas -
Analysis 2.1

Comparison 2 Radiological re‐expansion in patients with an atelectasis before RT, Outcome 1 Radiological re‐expansion EBRT + EBB vs EBRT + EBB.

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Comparison 3 Response rate of dyspnea, Outcome 1 Response of dyspnea EBRT + EBB vs EBRT.
Figuras y tablas -
Analysis 3.1

Comparison 3 Response rate of dyspnea, Outcome 1 Response of dyspnea EBRT + EBB vs EBRT.

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Comparison 3 Response rate of dyspnea, Outcome 2 Response of dyspnea EBB 8 Gy x 2 vs EBB 10 Gy x 1.
Figuras y tablas -
Analysis 3.2

Comparison 3 Response rate of dyspnea, Outcome 2 Response of dyspnea EBB 8 Gy x 2 vs EBB 10 Gy x 1.

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Comparison 4 Response of respiratory symptoms, Outcome 1 Response of cough EBRT + EBB vs EBRT.
Figuras y tablas -
Analysis 4.1

Comparison 4 Response of respiratory symptoms, Outcome 1 Response of cough EBRT + EBB vs EBRT.

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Comparison 4 Response of respiratory symptoms, Outcome 2 Response rate of hemoptysis (EBRT + EBB) vs EBRT.
Figuras y tablas -
Analysis 4.2

Comparison 4 Response of respiratory symptoms, Outcome 2 Response rate of hemoptysis (EBRT + EBB) vs EBRT.

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Comparison 4 Response of respiratory symptoms, Outcome 3 Response rate of chest pain (EBRT + EBB) vs EBRT.
Figuras y tablas -
Analysis 4.3

Comparison 4 Response of respiratory symptoms, Outcome 3 Response rate of chest pain (EBRT + EBB) vs EBRT.

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Comparison 4 Response of respiratory symptoms, Outcome 4 Response rate of pain in the arm/shoulder (EBRT + EBB) vs EBRT.
Figuras y tablas -
Analysis 4.4

Comparison 4 Response of respiratory symptoms, Outcome 4 Response rate of pain in the arm/shoulder (EBRT + EBB) vs EBRT.

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Comparison 4 Response of respiratory symptoms, Outcome 5 Positive cough response at 8 weeks‐ Clinician assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.5

Comparison 4 Response of respiratory symptoms, Outcome 5 Positive cough response at 8 weeks‐ Clinician assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 6 Positive hemoptysis response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.6

Comparison 4 Response of respiratory symptoms, Outcome 6 Positive hemoptysis response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 7 Positive breathlessness response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.7

Comparison 4 Response of respiratory symptoms, Outcome 7 Positive breathlessness response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 8 Positive chest pain response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.8

Comparison 4 Response of respiratory symptoms, Outcome 8 Positive chest pain response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 9 Positive dysphagia response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.9

Comparison 4 Response of respiratory symptoms, Outcome 9 Positive dysphagia response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 10 Positive anorexia response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.10

Comparison 4 Response of respiratory symptoms, Outcome 10 Positive anorexia response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 11 Positive tiredness response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.11

Comparison 4 Response of respiratory symptoms, Outcome 11 Positive tiredness response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 12 Positive nausea response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.12

Comparison 4 Response of respiratory symptoms, Outcome 12 Positive nausea response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 13 Positive hoarseness response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.13

Comparison 4 Response of respiratory symptoms, Outcome 13 Positive hoarseness response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 14 Positive cough response at 8 weeks ‐ Patient assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.14

Comparison 4 Response of respiratory symptoms, Outcome 14 Positive cough response at 8 weeks ‐ Patient assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 15 Positive hemoptysis response at 8 weeks ‐ Patient assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.15

Comparison 4 Response of respiratory symptoms, Outcome 15 Positive hemoptysis response at 8 weeks ‐ Patient assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 16 Positive breathlessness response at 8 weeks ‐ patient assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.16

Comparison 4 Response of respiratory symptoms, Outcome 16 Positive breathlessness response at 8 weeks ‐ patient assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 17 Positive chest pain response at 8 weeks ‐ Patient assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.17

Comparison 4 Response of respiratory symptoms, Outcome 17 Positive chest pain response at 8 weeks ‐ Patient assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 18 Positive dysphagia response at 8 weeks ‐ Patient assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.18

Comparison 4 Response of respiratory symptoms, Outcome 18 Positive dysphagia response at 8 weeks ‐ Patient assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 19 Positive anorexia response at 8 weeks ‐ Patient assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.19

Comparison 4 Response of respiratory symptoms, Outcome 19 Positive anorexia response at 8 weeks ‐ Patient assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 20 Positive tiredness response at 8 weeks ‐ Patient assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.20

Comparison 4 Response of respiratory symptoms, Outcome 20 Positive tiredness response at 8 weeks ‐ Patient assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 21 Positive nausea response at 8 weeks ‐ Patient assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.21

Comparison 4 Response of respiratory symptoms, Outcome 21 Positive nausea response at 8 weeks ‐ Patient assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 22 Positive hoarseness response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.22

Comparison 4 Response of respiratory symptoms, Outcome 22 Positive hoarseness response at 8 weeks ‐ Clinician assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 23 Good global palliation at 8 weeks ‐ Clinician assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.23

Comparison 4 Response of respiratory symptoms, Outcome 23 Good global palliation at 8 weeks ‐ Clinician assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 24 Good global palliation at 8 weeks ‐ Patient assessment (EBB vs EBRT).
Figuras y tablas -
Analysis 4.24

Comparison 4 Response of respiratory symptoms, Outcome 24 Good global palliation at 8 weeks ‐ Patient assessment (EBB vs EBRT).

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Comparison 4 Response of respiratory symptoms, Outcome 25 Response of cough EBRT + EBB vs EBRT during follow‐up.
Figuras y tablas -
Analysis 4.25

Comparison 4 Response of respiratory symptoms, Outcome 25 Response of cough EBRT + EBB vs EBRT during follow‐up.

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Comparison 4 Response of respiratory symptoms, Outcome 26 Response rate of hemoptysis (EBRT + EBB) vs EBRT during follow‐up.
Figuras y tablas -
Analysis 4.26

Comparison 4 Response of respiratory symptoms, Outcome 26 Response rate of hemoptysis (EBRT + EBB) vs EBRT during follow‐up.

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Comparison 4 Response of respiratory symptoms, Outcome 27 Response rate obstructive pneumonia EBRT + EBB vs EBRT.
Figuras y tablas -
Analysis 4.27

Comparison 4 Response of respiratory symptoms, Outcome 27 Response rate obstructive pneumonia EBRT + EBB vs EBRT.

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Comparison 4 Response of respiratory symptoms, Outcome 28 Response of Cough EBB 8 Gy x 2 vs EBB 10 Gy x 1.
Figuras y tablas -
Analysis 4.28

Comparison 4 Response of respiratory symptoms, Outcome 28 Response of Cough EBB 8 Gy x 2 vs EBB 10 Gy x 1.

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Comparison 4 Response of respiratory symptoms, Outcome 29 Response of hemoptysis EBB 8 Gy x 2 vs EBB 10 Gy x 1.
Figuras y tablas -
Analysis 4.29

Comparison 4 Response of respiratory symptoms, Outcome 29 Response of hemoptysis EBB 8 Gy x 2 vs EBB 10 Gy x 1.

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Comparison 4 Response of respiratory symptoms, Outcome 30 Response of obstructive pneumonia EBB 8 Gy x 2 vs EBB 10 Gy x 1.
Figuras y tablas -
Analysis 4.30

Comparison 4 Response of respiratory symptoms, Outcome 30 Response of obstructive pneumonia EBB 8 Gy x 2 vs EBB 10 Gy x 1.

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Comparison 5 Cause of death, Outcome 1 Fatal massive haemoptysis (EBRT +EBB) vs EBRT.
Figuras y tablas -
Analysis 5.1

Comparison 5 Cause of death, Outcome 1 Fatal massive haemoptysis (EBRT +EBB) vs EBRT.

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Comparison 5 Cause of death, Outcome 2 Fatal hemoptysis (EEB 3,8 Gy x 4 vs EEB 7.4Gy x 2 ).
Figuras y tablas -
Analysis 5.2

Comparison 5 Cause of death, Outcome 2 Fatal hemoptysis (EEB 3,8 Gy x 4 vs EEB 7.4Gy x 2 ).

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Comparison 5 Cause of death, Outcome 3 Death due to haemoptysis or tracheomediastinal fistulation ((Etoposide + EBB) vs EBB).
Figuras y tablas -
Analysis 5.3

Comparison 5 Cause of death, Outcome 3 Death due to haemoptysis or tracheomediastinal fistulation ((Etoposide + EBB) vs EBB).

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Comparison 5 Cause of death, Outcome 4 Fatal massive haemoptysis (EBB vs EBRT).
Figuras y tablas -
Analysis 5.4

Comparison 5 Cause of death, Outcome 4 Fatal massive haemoptysis (EBB vs EBRT).

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Comparison 5 Cause of death, Outcome 5 Fatal hemoptysis (EBB 4 x 3.8 vs EBB 2 x 7.2).
Figuras y tablas -
Analysis 5.5

Comparison 5 Cause of death, Outcome 5 Fatal hemoptysis (EBB 4 x 3.8 vs EBB 2 x 7.2).

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Comparison 6 Broncho‐pleural fistula, Outcome 1 Broncho‐pleural fistula (EBRT + EBB) vs EBRT.
Figuras y tablas -
Analysis 6.1

Comparison 6 Broncho‐pleural fistula, Outcome 1 Broncho‐pleural fistula (EBRT + EBB) vs EBRT.

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Comparison 7 Broncho‐esofageal fistula, Outcome 1 Broncho‐esofageal fistula (EBRT + EBB) vs EBRT.
Figuras y tablas -
Analysis 7.1

Comparison 7 Broncho‐esofageal fistula, Outcome 1 Broncho‐esofageal fistula (EBRT + EBB) vs EBRT.

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Comparison 8 Survival rate, Outcome 1 6 months survival rate (EBRT + EBB) vs EBRT.
Figuras y tablas -
Analysis 8.1

Comparison 8 Survival rate, Outcome 1 6 months survival rate (EBRT + EBB) vs EBRT.

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Comparison 8 Survival rate, Outcome 2 One year survival rate (EBRT + EBB) vs EBRT.
Figuras y tablas -
Analysis 8.2

Comparison 8 Survival rate, Outcome 2 One year survival rate (EBRT + EBB) vs EBRT.

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Comparison 8 Survival rate, Outcome 3 One year survival (EBB vs EBRT).
Figuras y tablas -
Analysis 8.3

Comparison 8 Survival rate, Outcome 3 One year survival (EBB vs EBRT).

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Comparison 8 Survival rate, Outcome 4 Two years survival (EBB vs EBRT).
Figuras y tablas -
Analysis 8.4

Comparison 8 Survival rate, Outcome 4 Two years survival (EBB vs EBRT).

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Comparison 8 Survival rate, Outcome 5 6 months survival rate (EBB 4 x 3.8 vs EBB 2 x 7.2).
Figuras y tablas -
Analysis 8.5

Comparison 8 Survival rate, Outcome 5 6 months survival rate (EBB 4 x 3.8 vs EBB 2 x 7.2).

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Comparison 8 Survival rate, Outcome 6 One year months survival rate (EBB 4 x 3.8 vs EBB 2 x 7.2).
Figuras y tablas -
Analysis 8.6

Comparison 8 Survival rate, Outcome 6 One year months survival rate (EBB 4 x 3.8 vs EBB 2 x 7.2).

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Comparison 9 Remission in local tumor, Outcome 1 Complete remission in local tumor at 3 months (Etoposide + EBB) vs EBB.
Figuras y tablas -
Analysis 9.1

Comparison 9 Remission in local tumor, Outcome 1 Complete remission in local tumor at 3 months (Etoposide + EBB) vs EBB.

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Comparison 9 Remission in local tumor, Outcome 2 Partial remission in local tumor at 3 months (Etoposide + EBB) vs EBB.
Figuras y tablas -
Analysis 9.2

Comparison 9 Remission in local tumor, Outcome 2 Partial remission in local tumor at 3 months (Etoposide + EBB) vs EBB.

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Comparison 9 Remission in local tumor, Outcome 3 Complete remission at 3 months (EBB 4 x 3.8 vs EBB 2 x 7.2).
Figuras y tablas -
Analysis 9.3

Comparison 9 Remission in local tumor, Outcome 3 Complete remission at 3 months (EBB 4 x 3.8 vs EBB 2 x 7.2).

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Comparison 9 Remission in local tumor, Outcome 4 Partial remission at 3 months (EBB 4 x 3.8 vs EBB 2 x 7.2).
Figuras y tablas -
Analysis 9.4

Comparison 9 Remission in local tumor, Outcome 4 Partial remission at 3 months (EBB 4 x 3.8 vs EBB 2 x 7.2).

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Comparison 10 Bronchoscopy Speiser’s index, Outcome 1 Speiser’s index (Nd‐YAG laser + EBB) vs Nd‐YAG laser.
Figuras y tablas -
Analysis 10.1

Comparison 10 Bronchoscopy Speiser’s index, Outcome 1 Speiser’s index (Nd‐YAG laser + EBB) vs Nd‐YAG laser.

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Comparison 11 Period free from disease, Outcome 1 period free from disease (months) ‐ (Nd‐YAG laser + EBB) vs Nd‐YAG laser.
Figuras y tablas -
Analysis 11.1

Comparison 11 Period free from disease, Outcome 1 period free from disease (months) ‐ (Nd‐YAG laser + EBB) vs Nd‐YAG laser.

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Comparison 12 Re‐treatment, Outcome 1 Re‐treatment (EBB vs EBRT).
Figuras y tablas -
Analysis 12.1

Comparison 12 Re‐treatment, Outcome 1 Re‐treatment (EBB vs EBRT).

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Comparison 1. Compliance to treatment

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Compliance to treatment EBRT vs EBRT + EBB Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 1. Compliance to treatment
Ir a la tabla de la revisión
Comparison 2. Radiological re‐expansion in patients with an atelectasis before RT

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Radiological re‐expansion EBRT + EBB vs EBRT + EBB Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 2. Radiological re‐expansion in patients with an atelectasis before RT
Ir a la tabla de la revisión
Comparison 3. Response rate of dyspnea

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Response of dyspnea EBRT + EBB vs EBRT Show forest plot

2

125

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.87, 1.52]

2 Response of dyspnea EBB 8 Gy x 2 vs EBB 10 Gy x 1 Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 3. Response rate of dyspnea
Ir a la tabla de la revisión
Comparison 4. Response of respiratory symptoms

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Response of cough EBRT + EBB vs EBRT Show forest plot

2

127

Risk Ratio (M‐H, Random, 95% CI)

0.83 [0.48, 1.44]

2 Response rate of hemoptysis (EBRT + EBB) vs EBRT Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3 Response rate of chest pain (EBRT + EBB) vs EBRT Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 Response rate of pain in the arm/shoulder (EBRT + EBB) vs EBRT Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5 Positive cough response at 8 weeks‐ Clinician assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

6 Positive hemoptysis response at 8 weeks ‐ Clinician assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

7 Positive breathlessness response at 8 weeks ‐ Clinician assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

8 Positive chest pain response at 8 weeks ‐ Clinician assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

9 Positive dysphagia response at 8 weeks ‐ Clinician assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

10 Positive anorexia response at 8 weeks ‐ Clinician assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

11 Positive tiredness response at 8 weeks ‐ Clinician assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

12 Positive nausea response at 8 weeks ‐ Clinician assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

13 Positive hoarseness response at 8 weeks ‐ Clinician assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

14 Positive cough response at 8 weeks ‐ Patient assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

15 Positive hemoptysis response at 8 weeks ‐ Patient assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

16 Positive breathlessness response at 8 weeks ‐ patient assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

17 Positive chest pain response at 8 weeks ‐ Patient assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

18 Positive dysphagia response at 8 weeks ‐ Patient assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

19 Positive anorexia response at 8 weeks ‐ Patient assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

20 Positive tiredness response at 8 weeks ‐ Patient assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

21 Positive nausea response at 8 weeks ‐ Patient assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

22 Positive hoarseness response at 8 weeks ‐ Clinician assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

23 Good global palliation at 8 weeks ‐ Clinician assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

24 Good global palliation at 8 weeks ‐ Patient assessment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

25 Response of cough EBRT + EBB vs EBRT during follow‐up Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

26 Response rate of hemoptysis (EBRT + EBB) vs EBRT during follow‐up Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

27 Response rate obstructive pneumonia EBRT + EBB vs EBRT Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

28 Response of Cough EBB 8 Gy x 2 vs EBB 10 Gy x 1 Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

29 Response of hemoptysis EBB 8 Gy x 2 vs EBB 10 Gy x 1 Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

30 Response of obstructive pneumonia EBB 8 Gy x 2 vs EBB 10 Gy x 1 Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 4. Response of respiratory symptoms
Ir a la tabla de la revisión
Comparison 5. Cause of death

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Fatal massive haemoptysis (EBRT +EBB) vs EBRT Show forest plot

3

236

Risk Ratio (M‐H, Random, 95% CI)

1.57 [0.22, 11.08]

2 Fatal hemoptysis (EEB 3,8 Gy x 4 vs EEB 7.4Gy x 2 ) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3 Death due to haemoptysis or tracheomediastinal fistulation ((Etoposide + EBB) vs EBB) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 Fatal massive haemoptysis (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5 Fatal hemoptysis (EBB 4 x 3.8 vs EBB 2 x 7.2) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 5. Cause of death
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Comparison 6. Broncho‐pleural fistula

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Broncho‐pleural fistula (EBRT + EBB) vs EBRT Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 6. Broncho‐pleural fistula
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Comparison 7. Broncho‐esofageal fistula

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Broncho‐esofageal fistula (EBRT + EBB) vs EBRT Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 7. Broncho‐esofageal fistula
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Comparison 8. Survival rate

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 6 months survival rate (EBRT + EBB) vs EBRT Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 One year survival rate (EBRT + EBB) vs EBRT Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3 One year survival (EBB vs EBRT) Show forest plot

2

174

Risk Ratio (M‐H, Fixed, 95% CI)

0.78 [0.49, 1.24]

4 Two years survival (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5 6 months survival rate (EBB 4 x 3.8 vs EBB 2 x 7.2) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

6 One year months survival rate (EBB 4 x 3.8 vs EBB 2 x 7.2) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 8. Survival rate
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Comparison 9. Remission in local tumor

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Complete remission in local tumor at 3 months (Etoposide + EBB) vs EBB Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Partial remission in local tumor at 3 months (Etoposide + EBB) vs EBB Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3 Complete remission at 3 months (EBB 4 x 3.8 vs EBB 2 x 7.2) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 Partial remission at 3 months (EBB 4 x 3.8 vs EBB 2 x 7.2) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 9. Remission in local tumor
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Comparison 10. Bronchoscopy Speiser’s index

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Speiser’s index (Nd‐YAG laser + EBB) vs Nd‐YAG laser Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 10. Bronchoscopy Speiser’s index
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Comparison 11. Period free from disease

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 period free from disease (months) ‐ (Nd‐YAG laser + EBB) vs Nd‐YAG laser Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 11. Period free from disease
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Comparison 12. Re‐treatment

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Re‐treatment (EBB vs EBRT) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 12. Re‐treatment
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