Palliative radiotherapy regimens for non‐small cell lung cancer

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Table 1. Radiotherapy regimens and biological effective doses (BED)

RT REGIMEN	STUDY	BED(10): Gy	BED(25): Gy	BED(1.7): Gy
60Gy/39F/6W	Nestle 2000	72	65	131
50Gy/25F/5W	Reinfuss 1999; Sundstrom 2004	60	54	109
45Gy/15/3.5W (4 days per week)	Abratt 1995	59	50	109
45Gy/18F/3.4W	Teo 1988	56	50	111
40GY/10F/4W(split)	Reinfuss 1999; Simpson 1985	56	46	134
42Gy/15F/3W	Sundstrom 2004	54	47	111
39Gy/13F/2.4W	MRC 1996	51	44	108
40Gy/20F/4W	Simpson 1985	48	43	87
36Gy/12F/2.3W	MRC1996	47	40	100
35Gy/10F/2.2W (4 days per week)	Abratt 1995	47	40	107
32Gy/16F/10d (twice daily)	Nestle 2000	38	35	70
31.2Gy/4F/4W (weekly)	Teo 1988	55	41	174
30Gy/10F/2W	MRC 1991, Simpson 1985, Kramer 2005, Erridge 2005	39	34	83
27Gy/6F/2W (3 days per week)	MRC 1991	39	32	98
22.5Gy/5F/5d	Rees 1997	33	27	82
20Gy/5F/5d	Senkus‐Konefka 2005, Bezjak 2002	28	23	67
17Gy/2F/8d (weekly)	MRC 1991, MRC 1992, MRC 1996, Rees 1997, Sundstrom 2004	31	23	102
16Gy/2F/8d (weekly)	Senkus‐Konefka 2005, Kramer 2005	29	21	91
10Gy/1F/1d	MRC 1992, Bezjak 2002, Erridge 2005	20	14	69
BED(y): biologically effective dose (Gy), calculated by the formula: BED(y) = n x d (1+ d/ (alpha/beta)), where n=number of fractions, d= size of each fraction(Gy), and alpha/beta is constant, of value y, for a given tissue type (Fowler 1989, Joiner 1997)

Table 1. Radiotherapy regimens and biological effective doses (BED)

Table 2. Survival data (*estimated from published data)

Table 2. Survival data (*estimated from published data)

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