1 PEFR values (end of study) Show forest plot

5

401

Std. Mean Difference (IV, Fixed, 95% CI)

0.33 [0.13, 0.53]

1.1 Absolute PEFR

2

269

Std. Mean Difference (IV, Fixed, 95% CI)

0.40 [0.16, 0.64]

1.2 % Predicted PEFR

3

132

Std. Mean Difference (IV, Fixed, 95% CI)

0.19 [‐0.15, 0.54]

2 FEV1 values (end of study) Show forest plot

5

Std. Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 Absoulte FEV1

4

237

Std. Mean Difference (IV, Fixed, 95% CI)

0.37 [0.12, 0.63]

2.2 Percent Predicted

5

257

Std. Mean Difference (IV, Fixed, 95% CI)

0.28 [0.03, 0.53]

3 Admission to hospital (end of observation period) Show forest plot

6

461

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.51, 0.92]

3.1 Moderate‐severe

5

341

Risk Ratio (M‐H, Fixed, 95% CI)

0.64 [0.47, 0.87]

3.2 Less severe

3

120

Risk Ratio (M‐H, Fixed, 95% CI)

1.12 [0.44, 2.85]

4 Adverse effects Show forest plot

4

292

Risk Ratio (M‐H, Fixed, 95% CI)

0.2 [0.03, 1.55]

5 ED treatment time Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

6 Respiratory therapist time Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

7 Symptom scores Show forest plot

2

112

Std. Mean Difference (IV, Fixed, 95% CI)

0.43 [0.05, 0.81]

8 Potassium concentration Show forest plot

3

206

Mean Difference (IV, Random, 95% CI)

0.02 [‐0.16, 0.19]

9 Pulse rate Show forest plot

5

373

Mean Difference (IV, Fixed, 95% CI)

‐2.87 [‐6.07, 0.34]

10 Respiratory rate (end of study) Show forest plot

2

62

Mean Difference (IV, Fixed, 95% CI)

1.0 [‐1.55, 3.55]

11 Blood pressure (end of study) Show forest plot

2

212

Mean Difference (IV, Fixed, 95% CI)

‐1.75 [‐5.55, 2.05]

12 Tremor Show forest plot

5

307

Risk Ratio (M‐H, Fixed, 95% CI)

0.81 [0.51, 1.28]

13 Palpitations Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

14 Nausea/vomiting Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

1 Early ( 1 hour or less) Show forest plot

9

Std. Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 PEFR

5

400

Std. Mean Difference (IV, Fixed, 95% CI)

0.14 [‐0.05, 0.34]

1.2 FEV‐1

5

257

Std. Mean Difference (IV, Fixed, 95% CI)

0.30 [0.05, 0.54]

2 2‐3 hours Show forest plot

9

Std. Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 PEFR

5

400

Std. Mean Difference (IV, Fixed, 95% CI)

0.37 [0.17, 0.57]

2.2 FEV‐1

5

257

Std. Mean Difference (IV, Fixed, 95% CI)

0.33 [0.08, 0.58]

3 4‐6 hours Show forest plot

2

Std. Mean Difference (IV, Fixed, 95% CI)

Subtotals only

3.1 PEFR

2

62

Std. Mean Difference (IV, Fixed, 95% CI)

0.16 [‐0.34, 0.67]

3.2 FEV‐1

1

20

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.38 [‐1.31, 0.55]