Scolaris Content Display Scolaris Content Display

Absolute PEFR values (end of study)
Figures and Tables -
Figure 1

Absolute PEFR values (end of study)

Absolute FEV1 values (end of study)
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Figure 2

Absolute FEV1 values (end of study)

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 1 PEFR values (end of study).
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Analysis 1.1

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 1 PEFR values (end of study).

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 2 FEV1 values (end of study).
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Analysis 1.2

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 2 FEV1 values (end of study).

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 3 Admission to hospital (end of observation period).
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Analysis 1.3

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 3 Admission to hospital (end of observation period).

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 4 Adverse effects.
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Analysis 1.4

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 4 Adverse effects.

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 5 ED treatment time.
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Analysis 1.5

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 5 ED treatment time.

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 6 Respiratory therapist time.
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Analysis 1.6

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 6 Respiratory therapist time.

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 7 Symptom scores.
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Analysis 1.7

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 7 Symptom scores.

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 8 Potassium concentration.
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Analysis 1.8

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 8 Potassium concentration.

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 9 Pulse rate.
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Analysis 1.9

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 9 Pulse rate.

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 10 Respiratory rate (end of study).
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Analysis 1.10

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 10 Respiratory rate (end of study).

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 11 Blood pressure (end of study).
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Analysis 1.11

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 11 Blood pressure (end of study).

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 12 Tremor.
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Analysis 1.12

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 12 Tremor.

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 13 Palpitations.
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Analysis 1.13

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 13 Palpitations.

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 14 Nausea/vomiting.
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Analysis 1.14

Comparison 1 Continuous vs intermittent nebulisation (end of study), Outcome 14 Nausea/vomiting.

Comparison 2 Continuous vs Intermittent PFT time line, Outcome 1 Early ( 1 hour or less).
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Analysis 2.1

Comparison 2 Continuous vs Intermittent PFT time line, Outcome 1 Early ( 1 hour or less).

Comparison 2 Continuous vs Intermittent PFT time line, Outcome 2 2‐3 hours.
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Analysis 2.2

Comparison 2 Continuous vs Intermittent PFT time line, Outcome 2 2‐3 hours.

Comparison 2 Continuous vs Intermittent PFT time line, Outcome 3 4‐6 hours.
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Analysis 2.3

Comparison 2 Continuous vs Intermittent PFT time line, Outcome 3 4‐6 hours.

Comparison 1. Continuous vs intermittent nebulisation (end of study)

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 PEFR values (end of study) Show forest plot

5

401

Std. Mean Difference (IV, Fixed, 95% CI)

0.33 [0.13, 0.53]

1.1 Absolute PEFR

2

269

Std. Mean Difference (IV, Fixed, 95% CI)

0.40 [0.16, 0.64]

1.2 % Predicted PEFR

3

132

Std. Mean Difference (IV, Fixed, 95% CI)

0.19 [‐0.15, 0.54]

2 FEV1 values (end of study) Show forest plot

5

Std. Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 Absoulte FEV1

4

237

Std. Mean Difference (IV, Fixed, 95% CI)

0.37 [0.12, 0.63]

2.2 Percent Predicted

5

257

Std. Mean Difference (IV, Fixed, 95% CI)

0.28 [0.03, 0.53]

3 Admission to hospital (end of observation period) Show forest plot

6

461

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.51, 0.92]

3.1 Moderate‐severe

5

341

Risk Ratio (M‐H, Fixed, 95% CI)

0.64 [0.47, 0.87]

3.2 Less severe

3

120

Risk Ratio (M‐H, Fixed, 95% CI)

1.12 [0.44, 2.85]

4 Adverse effects Show forest plot

4

292

Risk Ratio (M‐H, Fixed, 95% CI)

0.2 [0.03, 1.55]

5 ED treatment time Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

6 Respiratory therapist time Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

7 Symptom scores Show forest plot

2

112

Std. Mean Difference (IV, Fixed, 95% CI)

0.43 [0.05, 0.81]

8 Potassium concentration Show forest plot

3

206

Mean Difference (IV, Random, 95% CI)

0.02 [‐0.16, 0.19]

9 Pulse rate Show forest plot

5

373

Mean Difference (IV, Fixed, 95% CI)

‐2.87 [‐6.07, 0.34]

10 Respiratory rate (end of study) Show forest plot

2

62

Mean Difference (IV, Fixed, 95% CI)

1.0 [‐1.55, 3.55]

11 Blood pressure (end of study) Show forest plot

2

212

Mean Difference (IV, Fixed, 95% CI)

‐1.75 [‐5.55, 2.05]

12 Tremor Show forest plot

5

307

Risk Ratio (M‐H, Fixed, 95% CI)

0.81 [0.51, 1.28]

13 Palpitations Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

14 Nausea/vomiting Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

Figures and Tables -
Comparison 1. Continuous vs intermittent nebulisation (end of study)
Comparison 2. Continuous vs Intermittent PFT time line

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Early ( 1 hour or less) Show forest plot

9

Std. Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 PEFR

5

400

Std. Mean Difference (IV, Fixed, 95% CI)

0.14 [‐0.05, 0.34]

1.2 FEV‐1

5

257

Std. Mean Difference (IV, Fixed, 95% CI)

0.30 [0.05, 0.54]

2 2‐3 hours Show forest plot

9

Std. Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 PEFR

5

400

Std. Mean Difference (IV, Fixed, 95% CI)

0.37 [0.17, 0.57]

2.2 FEV‐1

5

257

Std. Mean Difference (IV, Fixed, 95% CI)

0.33 [0.08, 0.58]

3 4‐6 hours Show forest plot

2

Std. Mean Difference (IV, Fixed, 95% CI)

Subtotals only

3.1 PEFR

2

62

Std. Mean Difference (IV, Fixed, 95% CI)

0.16 [‐0.34, 0.67]

3.2 FEV‐1

1

20

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.38 [‐1.31, 0.55]

Figures and Tables -
Comparison 2. Continuous vs Intermittent PFT time line