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Comparison 1 Immediate hypothermia versus normothermia, Outcome 1 Death at final follow‐up.
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Analysis 1.1

Comparison 1 Immediate hypothermia versus normothermia, Outcome 1 Death at final follow‐up.

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Comparison 1 Immediate hypothermia versus normothermia, Outcome 2 Death or severe disability at final follow‐up.
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Analysis 1.2

Comparison 1 Immediate hypothermia versus normothermia, Outcome 2 Death or severe disability at final follow‐up.

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Comparison 1 Immediate hypothermia versus normothermia, Outcome 3 Death or severe disability stratified by quality.
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Analysis 1.3

Comparison 1 Immediate hypothermia versus normothermia, Outcome 3 Death or severe disability stratified by quality.

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Comparison 1 Immediate hypothermia versus normothermia, Outcome 4 Death or severe disability stratified by treatment duration.
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Analysis 1.4

Comparison 1 Immediate hypothermia versus normothermia, Outcome 4 Death or severe disability stratified by treatment duration.

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Comparison 1 Immediate hypothermia versus normothermia, Outcome 5 Death or severe disability at various times during follow‐up.
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Analysis 1.5

Comparison 1 Immediate hypothermia versus normothermia, Outcome 5 Death or severe disability at various times during follow‐up.

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Comparison 1 Immediate hypothermia versus normothermia, Outcome 6 Pneumonia during the treatment period.
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Analysis 1.6

Comparison 1 Immediate hypothermia versus normothermia, Outcome 6 Pneumonia during the treatment period.

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Comparison 2 Deferred hypothermia versus normothermia, Outcome 1 Death at final follow‐up.
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Analysis 2.1

Comparison 2 Deferred hypothermia versus normothermia, Outcome 1 Death at final follow‐up.

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Comparison 2 Deferred hypothermia versus normothermia, Outcome 2 Death or severe disability at final follow‐up.
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Analysis 2.2

Comparison 2 Deferred hypothermia versus normothermia, Outcome 2 Death or severe disability at final follow‐up.

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Comparison 2 Deferred hypothermia versus normothermia, Outcome 3 Death or severe disability at various times during follow‐up.
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Analysis 2.3

Comparison 2 Deferred hypothermia versus normothermia, Outcome 3 Death or severe disability at various times during follow‐up.

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Comparison 2 Deferred hypothermia versus normothermia, Outcome 4 Death or severe disability stratified by quality.
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Analysis 2.4

Comparison 2 Deferred hypothermia versus normothermia, Outcome 4 Death or severe disability stratified by quality.

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Comparison 2 Deferred hypothermia versus normothermia, Outcome 5 Death or severe disability stratified by treatment duration.
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Analysis 2.5

Comparison 2 Deferred hypothermia versus normothermia, Outcome 5 Death or severe disability stratified by treatment duration.

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Comparison 2 Deferred hypothermia versus normothermia, Outcome 6 Pneumonia during the treatment period.
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Analysis 2.6

Comparison 2 Deferred hypothermia versus normothermia, Outcome 6 Pneumonia during the treatment period.

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Comparison 1. Immediate hypothermia versus normothermia

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Death at final follow‐up Show forest plot

13

1063

Odds Ratio (M‐H, Fixed, 95% CI)

0.80 [0.61, 1.04]

2 Death or severe disability at final follow‐up Show forest plot

9

746

Odds Ratio (M‐H, Fixed, 95% CI)

0.75 [0.56, 1.00]

3 Death or severe disability stratified by quality Show forest plot

9

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

3.1 Concealed allocation, blinded outcome assessment

3

494

Odds Ratio (M‐H, Fixed, 95% CI)

0.80 [0.56, 1.14]

3.2 Concealed allocation, non‐blinded outcome assessment

1

10

Odds Ratio (M‐H, Fixed, 95% CI)

0.38 [0.02, 6.35]

3.3 Non‐concealed allocation, blinded outcome assessment

2

113

Odds Ratio (M‐H, Fixed, 95% CI)

0.34 [0.16, 0.76]

3.4 Non‐concealed allocation, non‐blinded outcome assessment

3

129

Odds Ratio (M‐H, Fixed, 95% CI)

1.17 [0.58, 2.35]

4 Death or severe disability stratified by treatment duration Show forest plot

7

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

4.1 24 hours

2

91

Odds Ratio (M‐H, Fixed, 95% CI)

0.38 [0.16, 0.90]

4.2 48 hours

5

542

Odds Ratio (M‐H, Fixed, 95% CI)

0.97 [0.69, 1.36]

5 Death or severe disability at various times during follow‐up Show forest plot

9

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

5.1 3 months

5

250

Odds Ratio (M‐H, Fixed, 95% CI)

0.72 [0.43, 1.21]

5.2 6 months

4

492

Odds Ratio (M‐H, Fixed, 95% CI)

0.79 [0.55, 1.13]

5.3 12 months

2

168

Odds Ratio (M‐H, Fixed, 95% CI)

0.41 [0.22, 0.77]

6 Pneumonia during the treatment period Show forest plot

8

283

Odds Ratio (M‐H, Fixed, 95% CI)

1.95 [1.18, 3.23]
Figuras y tablas -
Comparison 1. Immediate hypothermia versus normothermia
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Comparison 2. Deferred hypothermia versus normothermia

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Death at final follow‐up Show forest plot

1

33

Odds Ratio (M‐H, Fixed, 95% CI)

0.21 [0.04, 1.05]

2 Death or severe disability at final follow‐up Show forest plot

1

33

Odds Ratio (M‐H, Fixed, 95% CI)

0.10 [0.01, 1.00]

3 Death or severe disability at various times during follow‐up Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

3.1 3 months

0

0

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.2 6 months

1

33

Odds Ratio (M‐H, Fixed, 95% CI)

0.10 [0.01, 1.00]

3.3 12 months

0

0

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Death or severe disability stratified by quality Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

4.1 Concealed allocation, blinded outcome assessment

0

0

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.2 Concealed allocation, non‐blinded outcome assessment

0

0

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.3 Non‐concealed allocation, blinded outcome assessment

1

33

Odds Ratio (M‐H, Fixed, 95% CI)

0.10 [0.01, 1.00]

4.4 Non‐concealed allocation, non‐blinded outcome assessment

0

0

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Death or severe disability stratified by treatment duration Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

5.1 24 hours

0

0

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5.2 48 hours

1

33

Odds Ratio (M‐H, Fixed, 95% CI)

0.10 [0.01, 1.00]

6 Pneumonia during the treatment period Show forest plot

1

22

Odds Ratio (M‐H, Fixed, 95% CI)

1.13 [0.18, 6.93]
Figuras y tablas -
Comparison 2. Deferred hypothermia versus normothermia
Ir a la tabla de la revisión