Circulatory volume expansion therapy for aneurysmal subarachnoid haemorrhage

Gabriel JE Rinkel; Valery L Feigin; Ale Algra; Jan van Gijn

doi:10.1002/14651858.CD000483.pub2

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Analysis 1.1

Comparison 1 Poor outcome, Outcome 1 treatment started after occlusion of the aneurysm.

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Analysis 2.1

Comparison 2 Case fatality, Outcome 1 treatment started after occlusion of the aneurysm.

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Analysis 3.1

Comparison 3 Secondary ischaemia, Outcome 1 clinical signs of secondary ischaemia.

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Analysis 3.2

Comparison 3 Secondary ischaemia, Outcome 2 infarct on CT/MR.

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Analysis 4.1

Comparison 4 Rebleeding, Outcome 1 treatment started after occlusion of the aneurysm.

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Analysis 5.1

Comparison 5 Complications, Outcome 1 treatment started after occlusion of the aneurysm.

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Comparison 1. Poor outcome

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 treatment started after occlusion of the aneurysm Show forest plot	2	114	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.45, 2.22]

Comparison 1. Poor outcome

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Comparison 2. Case fatality

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 treatment started after occlusion of the aneurysm Show forest plot	2	114	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.18, 3.20]

Comparison 2. Case fatality

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Comparison 3. Secondary ischaemia

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 clinical signs of secondary ischaemia Show forest plot	2	114	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.54, 2.16]

1.1 treatment started before occlusion of the aneurysm	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.2 treatment started after occlusion of the aneurysm	2	114	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.54, 2.16]
2 infarct on CT/MR Show forest plot	1	82	Risk Ratio (M‐H, Fixed, 95% CI)	1.75 [0.55, 5.53]

2.1 treatment started before occlusion of the aneurysm	0	0	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.2 treatment started after occlusion of the aneurysm	1	82	Risk Ratio (M‐H, Fixed, 95% CI)	1.75 [0.55, 5.53]

Comparison 3. Secondary ischaemia

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Comparison 4. Rebleeding

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 treatment started after occlusion of the aneurysm Show forest plot	1	32	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]

Comparison 4. Rebleeding

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Comparison 5. Complications

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 treatment started after occlusion of the aneurysm Show forest plot	2	114	Risk Ratio (M‐H, Fixed, 95% CI)	1.78 [0.85, 3.71]

Comparison 5. Complications

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