Scolaris Content Display Scolaris Content Display

Comparison 1 Naproxen 1250 mg per day versus placebo, Outcome 1 Menstrual blood loss.
Figures and Tables -
Analysis 1.1

Comparison 1 Naproxen 1250 mg per day versus placebo, Outcome 1 Menstrual blood loss.

Comparison 2 Naproxen 1000 mg (Day 1) then 750 mg per day versus placebo, Outcome 1 Menstrual blood loss.
Figures and Tables -
Analysis 2.1

Comparison 2 Naproxen 1000 mg (Day 1) then 750 mg per day versus placebo, Outcome 1 Menstrual blood loss.

Comparison 3 Naproxen 1250 mg versus naproxen 1000 mg (Day 1) then 750 mg per day, Outcome 1 Menstrual blood loss.
Figures and Tables -
Analysis 3.1

Comparison 3 Naproxen 1250 mg versus naproxen 1000 mg (Day 1) then 750 mg per day, Outcome 1 Menstrual blood loss.

Comparison 4 Suprofen 800 mg (Day 1) then 600 mg per day versus placebo, Outcome 1 Moderate or "intense" decrease in bleeding.
Figures and Tables -
Analysis 4.1

Comparison 4 Suprofen 800 mg (Day 1) then 600 mg per day versus placebo, Outcome 1 Moderate or "intense" decrease in bleeding.

Comparison 4 Suprofen 800 mg (Day 1) then 600 mg per day versus placebo, Outcome 2 Moderate or "intense" relief of pain.
Figures and Tables -
Analysis 4.2

Comparison 4 Suprofen 800 mg (Day 1) then 600 mg per day versus placebo, Outcome 2 Moderate or "intense" relief of pain.

Comparison 5 Aspirin 1500 mg per day versus placebo, Outcome 1 Menstrual blood loss.
Figures and Tables -
Analysis 5.1

Comparison 5 Aspirin 1500 mg per day versus placebo, Outcome 1 Menstrual blood loss.

Study

Time period

Ibuprofen

Placebo

Jensen 1998

at insertion

3.3

2.5

Jensen 1998

first 4 to 6 hours

1.7

1.8

Jensen 1998

first day after insertion

1.4

1.3

Jensen 1998

second day after insertion

1.3

1.1

Jensen 1998

third day after insertion

1.1

1.1

Jensen 1998

Figures and Tables -
Analysis 6.1

Comparison 6 Ibuprofen 600 mg per day versus placebo, Outcome 1 Median pain values.

Comparison 7 Aspirin 1500 mg per day versus paracetamol 1500 mg per day, Outcome 1 Menstrual blood loss.
Figures and Tables -
Analysis 7.1

Comparison 7 Aspirin 1500 mg per day versus paracetamol 1500 mg per day, Outcome 1 Menstrual blood loss.

Comparison 8 Mefenamic acid 1500 mg per day versus desmopressin 300 mcg nasally per day, Outcome 1 Pictorial blood loss assessment chart.
Figures and Tables -
Analysis 8.1

Comparison 8 Mefenamic acid 1500 mg per day versus desmopressin 300 mcg nasally per day, Outcome 1 Pictorial blood loss assessment chart.

Comparison 9 Iboprofen 1600 mg per day versus placebo, Outcome 1 Menstrual blood loss.
Figures and Tables -
Analysis 9.1

Comparison 9 Iboprofen 1600 mg per day versus placebo, Outcome 1 Menstrual blood loss.

Comparison 10 Indomethacin 100 mg daily or flufenamic acid 600 mg daily or alclofenac 1500 mg daily versus placebo, Outcome 1 Menstrual blood loss.
Figures and Tables -
Analysis 10.1

Comparison 10 Indomethacin 100 mg daily or flufenamic acid 600 mg daily or alclofenac 1500 mg daily versus placebo, Outcome 1 Menstrual blood loss.

Comparison 10 Indomethacin 100 mg daily or flufenamic acid 600 mg daily or alclofenac 1500 mg daily versus placebo, Outcome 2 Severe or moderate pain.
Figures and Tables -
Analysis 10.2

Comparison 10 Indomethacin 100 mg daily or flufenamic acid 600 mg daily or alclofenac 1500 mg daily versus placebo, Outcome 2 Severe or moderate pain.

Comparison 11 Indomethacin 50 mg per day versus Baofuxin 16 g per day, Outcome 1 Bleeding/spotting days.
Figures and Tables -
Analysis 11.1

Comparison 11 Indomethacin 50 mg per day versus Baofuxin 16 g per day, Outcome 1 Bleeding/spotting days.

Comparison 11 Indomethacin 50 mg per day versus Baofuxin 16 g per day, Outcome 2 Bleeding/spotting episodes.
Figures and Tables -
Analysis 11.2

Comparison 11 Indomethacin 50 mg per day versus Baofuxin 16 g per day, Outcome 2 Bleeding/spotting episodes.

Comparison 12 Indomethacin 100 mg per day versus placebo, Outcome 1 Menstrual blood loss.
Figures and Tables -
Analysis 12.1

Comparison 12 Indomethacin 100 mg per day versus placebo, Outcome 1 Menstrual blood loss.

Comparison 13 Diclofenac sodium 150 mg then 75 mg versus tranexamic acid 4.5 mg per day, Outcome 1 Menstrual blood loss.
Figures and Tables -
Analysis 13.1

Comparison 13 Diclofenac sodium 150 mg then 75 mg versus tranexamic acid 4.5 mg per day, Outcome 1 Menstrual blood loss.

Comparison 14 Diclofenac sodium 150 mg (Day 1) then 75 mg on days 2‐5 versus placebo, Outcome 1 Menstrual blood loss.
Figures and Tables -
Analysis 14.1

Comparison 14 Diclofenac sodium 150 mg (Day 1) then 75 mg on days 2‐5 versus placebo, Outcome 1 Menstrual blood loss.

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 1 Duration of bleeding after IUD insertion.
Figures and Tables -
Analysis 15.1

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 1 Duration of bleeding after IUD insertion.

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 2 Number of sanitary pads used for bleeding immediately after IUD insertion.
Figures and Tables -
Analysis 15.2

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 2 Number of sanitary pads used for bleeding immediately after IUD insertion.

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 3 Next menses more abundant than normal.
Figures and Tables -
Analysis 15.3

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 3 Next menses more abundant than normal.

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 4 Clots in menstrual blood with subsequent menses.
Figures and Tables -
Analysis 15.4

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 4 Clots in menstrual blood with subsequent menses.

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 5 Subsequent menses more painful than normal.
Figures and Tables -
Analysis 15.5

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 5 Subsequent menses more painful than normal.

Comparison 16 Naproxen sodium 550 mg then 275 mg every 6 hr as needed versus placebo, Outcome 1 "Good" or "excellent" relief of uterine pain in one or more cycles.
Figures and Tables -
Analysis 16.1

Comparison 16 Naproxen sodium 550 mg then 275 mg every 6 hr as needed versus placebo, Outcome 1 "Good" or "excellent" relief of uterine pain in one or more cycles.

Comparison 16 Naproxen sodium 550 mg then 275 mg every 6 hr as needed versus placebo, Outcome 2 Mean daily pain relief scores.
Figures and Tables -
Analysis 16.2

Comparison 16 Naproxen sodium 550 mg then 275 mg every 6 hr as needed versus placebo, Outcome 2 Mean daily pain relief scores.

Comparison 17 Naproxen 500 mg initially then additional doses of 250 mg up to 1250 mg per day versus placebo, Outcome 1 Pain relief rated better than alternative treatment.
Figures and Tables -
Analysis 17.1

Comparison 17 Naproxen 500 mg initially then additional doses of 250 mg up to 1250 mg per day versus placebo, Outcome 1 Pain relief rated better than alternative treatment.

Comparison 18 Naproxen 1200 mg per day versus placebo, Outcome 1 Need for additional analgesia after IUD insertion.
Figures and Tables -
Analysis 18.1

Comparison 18 Naproxen 1200 mg per day versus placebo, Outcome 1 Need for additional analgesia after IUD insertion.

Comparison 19 Ibuprofen 1200 mg per day versus placebo with 6 menses after IUD insertion, Outcome 1 IUD removal by 26 weeks for dysmenorrhea or increased menstrual blood loss.
Figures and Tables -
Analysis 19.1

Comparison 19 Ibuprofen 1200 mg per day versus placebo with 6 menses after IUD insertion, Outcome 1 IUD removal by 26 weeks for dysmenorrhea or increased menstrual blood loss.

Comparison 19 Ibuprofen 1200 mg per day versus placebo with 6 menses after IUD insertion, Outcome 2 IUD removal by 52 weeks.
Figures and Tables -
Analysis 19.2

Comparison 19 Ibuprofen 1200 mg per day versus placebo with 6 menses after IUD insertion, Outcome 2 IUD removal by 52 weeks.

Comparison 1. Naproxen 1250 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

47

Mean Difference (IV, Fixed, 95% CI)

‐36.0 [‐57.17, ‐14.83]

Figures and Tables -
Comparison 1. Naproxen 1250 mg per day versus placebo
Comparison 2. Naproxen 1000 mg (Day 1) then 750 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

49

Mean Difference (IV, Fixed, 95% CI)

‐40.0 [‐55.40, ‐24.60]

Figures and Tables -
Comparison 2. Naproxen 1000 mg (Day 1) then 750 mg per day versus placebo
Comparison 3. Naproxen 1250 mg versus naproxen 1000 mg (Day 1) then 750 mg per day

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

40

Mean Difference (IV, Fixed, 95% CI)

4.0 [‐16.11, 24.11]

Figures and Tables -
Comparison 3. Naproxen 1250 mg versus naproxen 1000 mg (Day 1) then 750 mg per day
Comparison 4. Suprofen 800 mg (Day 1) then 600 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Moderate or "intense" decrease in bleeding Show forest plot

1

56

Odds Ratio (M‐H, Fixed, 95% CI)

197.31 [10.55, 3691.66]

2 Moderate or "intense" relief of pain Show forest plot

1

56

Odds Ratio (M‐H, Fixed, 95% CI)

124.2 [13.52, 1141.14]

Figures and Tables -
Comparison 4. Suprofen 800 mg (Day 1) then 600 mg per day versus placebo
Comparison 5. Aspirin 1500 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

20

Mean Difference (IV, Fixed, 95% CI)

‐1.5 [‐29.60, 26.60]

Figures and Tables -
Comparison 5. Aspirin 1500 mg per day versus placebo
Comparison 6. Ibuprofen 600 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Median pain values Show forest plot

Other data

No numeric data

Figures and Tables -
Comparison 6. Ibuprofen 600 mg per day versus placebo
Comparison 7. Aspirin 1500 mg per day versus paracetamol 1500 mg per day

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

20

Mean Difference (IV, Fixed, 95% CI)

‐0.30 [‐26.16, 25.56]

Figures and Tables -
Comparison 7. Aspirin 1500 mg per day versus paracetamol 1500 mg per day
Comparison 8. Mefenamic acid 1500 mg per day versus desmopressin 300 mcg nasally per day

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Pictorial blood loss assessment chart Show forest plot

1

24

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

Figures and Tables -
Comparison 8. Mefenamic acid 1500 mg per day versus desmopressin 300 mcg nasally per day
Comparison 9. Iboprofen 1600 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

40

Mean Difference (IV, Fixed, 95% CI)

‐14.11 [‐36.04, 7.82]

1.1 Copper IUD users

1

20

Mean Difference (IV, Fixed, 95% CI)

‐9.47 [‐34.46, 15.52]

1.2 Lippes Loop users

1

20

Mean Difference (IV, Fixed, 95% CI)

‐29.68 [‐75.44, 16.08]

Figures and Tables -
Comparison 9. Iboprofen 1600 mg per day versus placebo
Comparison 10. Indomethacin 100 mg daily or flufenamic acid 600 mg daily or alclofenac 1500 mg daily versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

36

Mean Difference (IV, Fixed, 95% CI)

‐39.8 [‐42.84, ‐36.76]

2 Severe or moderate pain Show forest plot

1

36

Odds Ratio (M‐H, Fixed, 95% CI)

0.00 [0.00, 0.06]

Figures and Tables -
Comparison 10. Indomethacin 100 mg daily or flufenamic acid 600 mg daily or alclofenac 1500 mg daily versus placebo
Comparison 11. Indomethacin 50 mg per day versus Baofuxin 16 g per day

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Bleeding/spotting days Show forest plot

1

144

Mean Difference (IV, Fixed, 95% CI)

0.5 [‐2.96, 3.96]

2 Bleeding/spotting episodes Show forest plot

1

144

Mean Difference (IV, Fixed, 95% CI)

0.10 [‐0.38, 0.58]

Figures and Tables -
Comparison 11. Indomethacin 50 mg per day versus Baofuxin 16 g per day
Comparison 12. Indomethacin 100 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

36

Mean Difference (IV, Fixed, 95% CI)

‐85.22 [‐119.27, ‐51.17]

Figures and Tables -
Comparison 12. Indomethacin 100 mg per day versus placebo
Comparison 13. Diclofenac sodium 150 mg then 75 mg versus tranexamic acid 4.5 mg per day

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

38

Mean Difference (IV, Fixed, 95% CI)

42.70 [12.05, 73.35]

Figures and Tables -
Comparison 13. Diclofenac sodium 150 mg then 75 mg versus tranexamic acid 4.5 mg per day
Comparison 14. Diclofenac sodium 150 mg (Day 1) then 75 mg on days 2‐5 versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

38

Mean Difference (IV, Fixed, 95% CI)

‐26.20 [‐66.77, 14.37]

Figures and Tables -
Comparison 14. Diclofenac sodium 150 mg (Day 1) then 75 mg on days 2‐5 versus placebo
Comparison 15. Tolfenamic acid 600 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Duration of bleeding after IUD insertion Show forest plot

1

122

Mean Difference (IV, Fixed, 95% CI)

‐0.60 [‐1.51, 0.31]

2 Number of sanitary pads used for bleeding immediately after IUD insertion Show forest plot

1

122

Mean Difference (IV, Fixed, 95% CI)

‐1.4 [‐2.06, ‐0.74]

3 Next menses more abundant than normal Show forest plot

1

310

Odds Ratio (M‐H, Fixed, 95% CI)

0.54 [0.34, 0.85]

4 Clots in menstrual blood with subsequent menses Show forest plot

1

310

Odds Ratio (M‐H, Fixed, 95% CI)

0.43 [0.27, 0.68]

5 Subsequent menses more painful than normal Show forest plot

1

310

Odds Ratio (M‐H, Fixed, 95% CI)

0.71 [0.44, 1.14]

Figures and Tables -
Comparison 15. Tolfenamic acid 600 mg per day versus placebo
Comparison 16. Naproxen sodium 550 mg then 275 mg every 6 hr as needed versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 "Good" or "excellent" relief of uterine pain in one or more cycles Show forest plot

1

33

Odds Ratio (M‐H, Fixed, 95% CI)

14.0 [2.60, 75.41]

2 Mean daily pain relief scores Show forest plot

1

27

Mean Difference (IV, Fixed, 95% CI)

3.10 [0.27, 5.93]

Figures and Tables -
Comparison 16. Naproxen sodium 550 mg then 275 mg every 6 hr as needed versus placebo
Comparison 17. Naproxen 500 mg initially then additional doses of 250 mg up to 1250 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Pain relief rated better than alternative treatment Show forest plot

1

40

Odds Ratio (M‐H, Fixed, 95% CI)

32.11 [5.66, 182.18]

Figures and Tables -
Comparison 17. Naproxen 500 mg initially then additional doses of 250 mg up to 1250 mg per day versus placebo
Comparison 18. Naproxen 1200 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Need for additional analgesia after IUD insertion Show forest plot

1

50

Odds Ratio (M‐H, Fixed, 95% CI)

0.22 [0.07, 0.72]

Figures and Tables -
Comparison 18. Naproxen 1200 mg per day versus placebo
Comparison 19. Ibuprofen 1200 mg per day versus placebo with 6 menses after IUD insertion

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 IUD removal by 26 weeks for dysmenorrhea or increased menstrual blood loss Show forest plot

1

1962

Odds Ratio (M‐H, Fixed, 95% CI)

0.96 [0.66, 1.38]

2 IUD removal by 52 weeks Show forest plot

1

1962

Odds Ratio (M‐H, Fixed, 95% CI)

1.05 [0.86, 1.28]

Figures and Tables -
Comparison 19. Ibuprofen 1200 mg per day versus placebo with 6 menses after IUD insertion