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Comparison 1 Naproxen 1250 mg per day versus placebo, Outcome 1 Menstrual blood loss.
Figuras y tablas -
Analysis 1.1

Comparison 1 Naproxen 1250 mg per day versus placebo, Outcome 1 Menstrual blood loss.

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Comparison 2 Naproxen 1000 mg (Day 1) then 750 mg per day versus placebo, Outcome 1 Menstrual blood loss.
Figuras y tablas -
Analysis 2.1

Comparison 2 Naproxen 1000 mg (Day 1) then 750 mg per day versus placebo, Outcome 1 Menstrual blood loss.

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Comparison 3 Naproxen 1250 mg versus naproxen 1000 mg (Day 1) then 750 mg per day, Outcome 1 Menstrual blood loss.
Figuras y tablas -
Analysis 3.1

Comparison 3 Naproxen 1250 mg versus naproxen 1000 mg (Day 1) then 750 mg per day, Outcome 1 Menstrual blood loss.

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Comparison 4 Suprofen 800 mg (Day 1) then 600 mg per day versus placebo, Outcome 1 Moderate or "intense" decrease in bleeding.
Figuras y tablas -
Analysis 4.1

Comparison 4 Suprofen 800 mg (Day 1) then 600 mg per day versus placebo, Outcome 1 Moderate or "intense" decrease in bleeding.

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Comparison 4 Suprofen 800 mg (Day 1) then 600 mg per day versus placebo, Outcome 2 Moderate or "intense" relief of pain.
Figuras y tablas -
Analysis 4.2

Comparison 4 Suprofen 800 mg (Day 1) then 600 mg per day versus placebo, Outcome 2 Moderate or "intense" relief of pain.

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Comparison 5 Aspirin 1500 mg per day versus placebo, Outcome 1 Menstrual blood loss.
Figuras y tablas -
Analysis 5.1

Comparison 5 Aspirin 1500 mg per day versus placebo, Outcome 1 Menstrual blood loss.

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Study

Time period

Ibuprofen

Placebo

Jensen 1998

at insertion

3.3

2.5

Jensen 1998

first 4 to 6 hours

1.7

1.8

Jensen 1998

first day after insertion

1.4

1.3

Jensen 1998

second day after insertion

1.3

1.1

Jensen 1998

third day after insertion

1.1

1.1

Jensen 1998

Figuras y tablas -
Analysis 6.1

Comparison 6 Ibuprofen 600 mg per day versus placebo, Outcome 1 Median pain values.

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Comparison 7 Aspirin 1500 mg per day versus paracetamol 1500 mg per day, Outcome 1 Menstrual blood loss.
Figuras y tablas -
Analysis 7.1

Comparison 7 Aspirin 1500 mg per day versus paracetamol 1500 mg per day, Outcome 1 Menstrual blood loss.

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Comparison 8 Mefenamic acid 1500 mg per day versus desmopressin 300 mcg nasally per day, Outcome 1 Pictorial blood loss assessment chart.
Figuras y tablas -
Analysis 8.1

Comparison 8 Mefenamic acid 1500 mg per day versus desmopressin 300 mcg nasally per day, Outcome 1 Pictorial blood loss assessment chart.

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Comparison 9 Iboprofen 1600 mg per day versus placebo, Outcome 1 Menstrual blood loss.
Figuras y tablas -
Analysis 9.1

Comparison 9 Iboprofen 1600 mg per day versus placebo, Outcome 1 Menstrual blood loss.

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Comparison 10 Indomethacin 100 mg daily or flufenamic acid 600 mg daily or alclofenac 1500 mg daily versus placebo, Outcome 1 Menstrual blood loss.
Figuras y tablas -
Analysis 10.1

Comparison 10 Indomethacin 100 mg daily or flufenamic acid 600 mg daily or alclofenac 1500 mg daily versus placebo, Outcome 1 Menstrual blood loss.

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Comparison 10 Indomethacin 100 mg daily or flufenamic acid 600 mg daily or alclofenac 1500 mg daily versus placebo, Outcome 2 Severe or moderate pain.
Figuras y tablas -
Analysis 10.2

Comparison 10 Indomethacin 100 mg daily or flufenamic acid 600 mg daily or alclofenac 1500 mg daily versus placebo, Outcome 2 Severe or moderate pain.

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Comparison 11 Indomethacin 50 mg per day versus Baofuxin 16 g per day, Outcome 1 Bleeding/spotting days.
Figuras y tablas -
Analysis 11.1

Comparison 11 Indomethacin 50 mg per day versus Baofuxin 16 g per day, Outcome 1 Bleeding/spotting days.

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Comparison 11 Indomethacin 50 mg per day versus Baofuxin 16 g per day, Outcome 2 Bleeding/spotting episodes.
Figuras y tablas -
Analysis 11.2

Comparison 11 Indomethacin 50 mg per day versus Baofuxin 16 g per day, Outcome 2 Bleeding/spotting episodes.

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Comparison 12 Indomethacin 100 mg per day versus placebo, Outcome 1 Menstrual blood loss.
Figuras y tablas -
Analysis 12.1

Comparison 12 Indomethacin 100 mg per day versus placebo, Outcome 1 Menstrual blood loss.

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Comparison 13 Diclofenac sodium 150 mg then 75 mg versus tranexamic acid 4.5 mg per day, Outcome 1 Menstrual blood loss.
Figuras y tablas -
Analysis 13.1

Comparison 13 Diclofenac sodium 150 mg then 75 mg versus tranexamic acid 4.5 mg per day, Outcome 1 Menstrual blood loss.

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Comparison 14 Diclofenac sodium 150 mg (Day 1) then 75 mg on days 2‐5 versus placebo, Outcome 1 Menstrual blood loss.
Figuras y tablas -
Analysis 14.1

Comparison 14 Diclofenac sodium 150 mg (Day 1) then 75 mg on days 2‐5 versus placebo, Outcome 1 Menstrual blood loss.

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Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 1 Duration of bleeding after IUD insertion.
Figuras y tablas -
Analysis 15.1

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 1 Duration of bleeding after IUD insertion.

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Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 2 Number of sanitary pads used for bleeding immediately after IUD insertion.
Figuras y tablas -
Analysis 15.2

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 2 Number of sanitary pads used for bleeding immediately after IUD insertion.

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Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 3 Next menses more abundant than normal.
Figuras y tablas -
Analysis 15.3

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 3 Next menses more abundant than normal.

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Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 4 Clots in menstrual blood with subsequent menses.
Figuras y tablas -
Analysis 15.4

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 4 Clots in menstrual blood with subsequent menses.

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Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 5 Subsequent menses more painful than normal.
Figuras y tablas -
Analysis 15.5

Comparison 15 Tolfenamic acid 600 mg per day versus placebo, Outcome 5 Subsequent menses more painful than normal.

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Comparison 16 Naproxen sodium 550 mg then 275 mg every 6 hr as needed versus placebo, Outcome 1 "Good" or "excellent" relief of uterine pain in one or more cycles.
Figuras y tablas -
Analysis 16.1

Comparison 16 Naproxen sodium 550 mg then 275 mg every 6 hr as needed versus placebo, Outcome 1 "Good" or "excellent" relief of uterine pain in one or more cycles.

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Comparison 16 Naproxen sodium 550 mg then 275 mg every 6 hr as needed versus placebo, Outcome 2 Mean daily pain relief scores.
Figuras y tablas -
Analysis 16.2

Comparison 16 Naproxen sodium 550 mg then 275 mg every 6 hr as needed versus placebo, Outcome 2 Mean daily pain relief scores.

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Comparison 17 Naproxen 500 mg initially then additional doses of 250 mg up to 1250 mg per day versus placebo, Outcome 1 Pain relief rated better than alternative treatment.
Figuras y tablas -
Analysis 17.1

Comparison 17 Naproxen 500 mg initially then additional doses of 250 mg up to 1250 mg per day versus placebo, Outcome 1 Pain relief rated better than alternative treatment.

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Comparison 18 Naproxen 1200 mg per day versus placebo, Outcome 1 Need for additional analgesia after IUD insertion.
Figuras y tablas -
Analysis 18.1

Comparison 18 Naproxen 1200 mg per day versus placebo, Outcome 1 Need for additional analgesia after IUD insertion.

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Comparison 19 Ibuprofen 1200 mg per day versus placebo with 6 menses after IUD insertion, Outcome 1 IUD removal by 26 weeks for dysmenorrhea or increased menstrual blood loss.
Figuras y tablas -
Analysis 19.1

Comparison 19 Ibuprofen 1200 mg per day versus placebo with 6 menses after IUD insertion, Outcome 1 IUD removal by 26 weeks for dysmenorrhea or increased menstrual blood loss.

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Comparison 19 Ibuprofen 1200 mg per day versus placebo with 6 menses after IUD insertion, Outcome 2 IUD removal by 52 weeks.
Figuras y tablas -
Analysis 19.2

Comparison 19 Ibuprofen 1200 mg per day versus placebo with 6 menses after IUD insertion, Outcome 2 IUD removal by 52 weeks.

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Comparison 1. Naproxen 1250 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

47

Mean Difference (IV, Fixed, 95% CI)

‐36.0 [‐57.17, ‐14.83]
Figuras y tablas -
Comparison 1. Naproxen 1250 mg per day versus placebo
Ir a la tabla de la revisión
Comparison 2. Naproxen 1000 mg (Day 1) then 750 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

49

Mean Difference (IV, Fixed, 95% CI)

‐40.0 [‐55.40, ‐24.60]
Figuras y tablas -
Comparison 2. Naproxen 1000 mg (Day 1) then 750 mg per day versus placebo
Ir a la tabla de la revisión
Comparison 3. Naproxen 1250 mg versus naproxen 1000 mg (Day 1) then 750 mg per day

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

40

Mean Difference (IV, Fixed, 95% CI)

4.0 [‐16.11, 24.11]
Figuras y tablas -
Comparison 3. Naproxen 1250 mg versus naproxen 1000 mg (Day 1) then 750 mg per day
Ir a la tabla de la revisión
Comparison 4. Suprofen 800 mg (Day 1) then 600 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Moderate or "intense" decrease in bleeding Show forest plot

1

56

Odds Ratio (M‐H, Fixed, 95% CI)

197.31 [10.55, 3691.66]

2 Moderate or "intense" relief of pain Show forest plot

1

56

Odds Ratio (M‐H, Fixed, 95% CI)

124.2 [13.52, 1141.14]
Figuras y tablas -
Comparison 4. Suprofen 800 mg (Day 1) then 600 mg per day versus placebo
Ir a la tabla de la revisión
Comparison 5. Aspirin 1500 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

20

Mean Difference (IV, Fixed, 95% CI)

‐1.5 [‐29.60, 26.60]
Figuras y tablas -
Comparison 5. Aspirin 1500 mg per day versus placebo
Ir a la tabla de la revisión
Comparison 6. Ibuprofen 600 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Median pain values Show forest plot

Other data

No numeric data
Figuras y tablas -
Comparison 6. Ibuprofen 600 mg per day versus placebo
Ir a la tabla de la revisión
Comparison 7. Aspirin 1500 mg per day versus paracetamol 1500 mg per day

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

20

Mean Difference (IV, Fixed, 95% CI)

‐0.30 [‐26.16, 25.56]
Figuras y tablas -
Comparison 7. Aspirin 1500 mg per day versus paracetamol 1500 mg per day
Ir a la tabla de la revisión
Comparison 8. Mefenamic acid 1500 mg per day versus desmopressin 300 mcg nasally per day

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Pictorial blood loss assessment chart Show forest plot

1

24

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 8. Mefenamic acid 1500 mg per day versus desmopressin 300 mcg nasally per day
Ir a la tabla de la revisión
Comparison 9. Iboprofen 1600 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

40

Mean Difference (IV, Fixed, 95% CI)

‐14.11 [‐36.04, 7.82]

1.1 Copper IUD users

1

20

Mean Difference (IV, Fixed, 95% CI)

‐9.47 [‐34.46, 15.52]

1.2 Lippes Loop users

1

20

Mean Difference (IV, Fixed, 95% CI)

‐29.68 [‐75.44, 16.08]
Figuras y tablas -
Comparison 9. Iboprofen 1600 mg per day versus placebo
Ir a la tabla de la revisión
Comparison 10. Indomethacin 100 mg daily or flufenamic acid 600 mg daily or alclofenac 1500 mg daily versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

36

Mean Difference (IV, Fixed, 95% CI)

‐39.8 [‐42.84, ‐36.76]

2 Severe or moderate pain Show forest plot

1

36

Odds Ratio (M‐H, Fixed, 95% CI)

0.00 [0.00, 0.06]
Figuras y tablas -
Comparison 10. Indomethacin 100 mg daily or flufenamic acid 600 mg daily or alclofenac 1500 mg daily versus placebo
Ir a la tabla de la revisión
Comparison 11. Indomethacin 50 mg per day versus Baofuxin 16 g per day

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Bleeding/spotting days Show forest plot

1

144

Mean Difference (IV, Fixed, 95% CI)

0.5 [‐2.96, 3.96]

2 Bleeding/spotting episodes Show forest plot

1

144

Mean Difference (IV, Fixed, 95% CI)

0.10 [‐0.38, 0.58]
Figuras y tablas -
Comparison 11. Indomethacin 50 mg per day versus Baofuxin 16 g per day
Ir a la tabla de la revisión
Comparison 12. Indomethacin 100 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

36

Mean Difference (IV, Fixed, 95% CI)

‐85.22 [‐119.27, ‐51.17]
Figuras y tablas -
Comparison 12. Indomethacin 100 mg per day versus placebo
Ir a la tabla de la revisión
Comparison 13. Diclofenac sodium 150 mg then 75 mg versus tranexamic acid 4.5 mg per day

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

38

Mean Difference (IV, Fixed, 95% CI)

42.70 [12.05, 73.35]
Figuras y tablas -
Comparison 13. Diclofenac sodium 150 mg then 75 mg versus tranexamic acid 4.5 mg per day
Ir a la tabla de la revisión
Comparison 14. Diclofenac sodium 150 mg (Day 1) then 75 mg on days 2‐5 versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Menstrual blood loss Show forest plot

1

38

Mean Difference (IV, Fixed, 95% CI)

‐26.20 [‐66.77, 14.37]
Figuras y tablas -
Comparison 14. Diclofenac sodium 150 mg (Day 1) then 75 mg on days 2‐5 versus placebo
Ir a la tabla de la revisión
Comparison 15. Tolfenamic acid 600 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Duration of bleeding after IUD insertion Show forest plot

1

122

Mean Difference (IV, Fixed, 95% CI)

‐0.60 [‐1.51, 0.31]

2 Number of sanitary pads used for bleeding immediately after IUD insertion Show forest plot

1

122

Mean Difference (IV, Fixed, 95% CI)

‐1.4 [‐2.06, ‐0.74]

3 Next menses more abundant than normal Show forest plot

1

310

Odds Ratio (M‐H, Fixed, 95% CI)

0.54 [0.34, 0.85]

4 Clots in menstrual blood with subsequent menses Show forest plot

1

310

Odds Ratio (M‐H, Fixed, 95% CI)

0.43 [0.27, 0.68]

5 Subsequent menses more painful than normal Show forest plot

1

310

Odds Ratio (M‐H, Fixed, 95% CI)

0.71 [0.44, 1.14]
Figuras y tablas -
Comparison 15. Tolfenamic acid 600 mg per day versus placebo
Ir a la tabla de la revisión
Comparison 16. Naproxen sodium 550 mg then 275 mg every 6 hr as needed versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 "Good" or "excellent" relief of uterine pain in one or more cycles Show forest plot

1

33

Odds Ratio (M‐H, Fixed, 95% CI)

14.0 [2.60, 75.41]

2 Mean daily pain relief scores Show forest plot

1

27

Mean Difference (IV, Fixed, 95% CI)

3.10 [0.27, 5.93]
Figuras y tablas -
Comparison 16. Naproxen sodium 550 mg then 275 mg every 6 hr as needed versus placebo
Ir a la tabla de la revisión
Comparison 17. Naproxen 500 mg initially then additional doses of 250 mg up to 1250 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Pain relief rated better than alternative treatment Show forest plot

1

40

Odds Ratio (M‐H, Fixed, 95% CI)

32.11 [5.66, 182.18]
Figuras y tablas -
Comparison 17. Naproxen 500 mg initially then additional doses of 250 mg up to 1250 mg per day versus placebo
Ir a la tabla de la revisión
Comparison 18. Naproxen 1200 mg per day versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Need for additional analgesia after IUD insertion Show forest plot

1

50

Odds Ratio (M‐H, Fixed, 95% CI)

0.22 [0.07, 0.72]
Figuras y tablas -
Comparison 18. Naproxen 1200 mg per day versus placebo
Ir a la tabla de la revisión
Comparison 19. Ibuprofen 1200 mg per day versus placebo with 6 menses after IUD insertion

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 IUD removal by 26 weeks for dysmenorrhea or increased menstrual blood loss Show forest plot

1

1962

Odds Ratio (M‐H, Fixed, 95% CI)

0.96 [0.66, 1.38]

2 IUD removal by 52 weeks Show forest plot

1

1962

Odds Ratio (M‐H, Fixed, 95% CI)

1.05 [0.86, 1.28]
Figuras y tablas -
Comparison 19. Ibuprofen 1200 mg per day versus placebo with 6 menses after IUD insertion
Ir a la tabla de la revisión