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Forest plot of comparison: 1 Coenzyme Q10 vs placebo, outcome: 1.1 SBP.
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Figure 1

Forest plot of comparison: 1 Coenzyme Q10 vs placebo, outcome: 1.1 SBP.

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Forest plot of comparison: 1 Coenzyme Q10 vs placebo, outcome: 1.2 DBP.
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Figure 2

Forest plot of comparison: 1 Coenzyme Q10 vs placebo, outcome: 1.2 DBP.

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Forest plot of comparison: 1 Coenzyme Q10 vs placebo, outcome: 1.3 Heart rate.
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Figure 3

Forest plot of comparison: 1 Coenzyme Q10 vs placebo, outcome: 1.3 Heart rate.

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Comparison 1 Coenzyme Q10 vs placebo, Outcome 1 SBP.
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Analysis 1.1

Comparison 1 Coenzyme Q10 vs placebo, Outcome 1 SBP.

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Comparison 1 Coenzyme Q10 vs placebo, Outcome 2 DBP.
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Analysis 1.2

Comparison 1 Coenzyme Q10 vs placebo, Outcome 2 DBP.

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Comparison 1 Coenzyme Q10 vs placebo, Outcome 3 Heart rate.
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Analysis 1.3

Comparison 1 Coenzyme Q10 vs placebo, Outcome 3 Heart rate.

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Summary of findings for the main comparison. Coenzyme Q10 versus placebo in patients with essential arterial hypertension

Patient population: patients with essential arterial hypertension (SBP > 140 mmHg or DBP > 90 mmHg)

Settings: primary care in Japan, Italy and India

Intervention: coenzyme Q10

Comparison: placebo

Outcomes

Relative effect (95% CI)

Number of participants (studies)

Quality of evidence (GRADE)

Comments

Systolic blood pressure (SBP)

‐10.72 [‐13.77, ‐7.67]

96 (3)

Low

Diastolic blood pressure (DBP)

‐6.64 [‐8.10, ‐5.17]

96 (3)

Low

Change in heart rate (HR)

‐12.00 [‐15.19, ‐8.81]

58 (1)

Low

Number of withdrawals due to adverse effects compared to placebo

unknown, reason for withdrawals not reported in Singh 1999
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Summary of findings for the main comparison. Coenzyme Q10 versus placebo in patients with essential arterial hypertension
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Comparison 1. Coenzyme Q10 vs placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 SBP Show forest plot

3

96

Mean Difference (Fixed, 95% CI)

‐10.72 [‐13.77, ‐7.67]

2 DBP Show forest plot

3

96

Mean Difference (Fixed, 95% CI)

‐6.64 [‐8.10, ‐5.17]

3 Heart rate Show forest plot

1

58

Mean Difference (Fixed, 95% CI)

‐12.0 [‐15.19, ‐8.81]
Figures and Tables -
Comparison 1. Coenzyme Q10 vs placebo
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