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Forest plot of comparison: 1 Coenzyme Q10 vs placebo, outcome: 1.1 SBP.
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Figure 1

Forest plot of comparison: 1 Coenzyme Q10 vs placebo, outcome: 1.1 SBP.

Forest plot of comparison: 1 Coenzyme Q10 vs placebo, outcome: 1.2 DBP.
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Figure 2

Forest plot of comparison: 1 Coenzyme Q10 vs placebo, outcome: 1.2 DBP.

Forest plot of comparison: 1 Coenzyme Q10 vs placebo, outcome: 1.3 Heart rate.
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Figure 3

Forest plot of comparison: 1 Coenzyme Q10 vs placebo, outcome: 1.3 Heart rate.

Comparison 1 Coenzyme Q10 vs placebo, Outcome 1 SBP.
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Analysis 1.1

Comparison 1 Coenzyme Q10 vs placebo, Outcome 1 SBP.

Comparison 1 Coenzyme Q10 vs placebo, Outcome 2 DBP.
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Analysis 1.2

Comparison 1 Coenzyme Q10 vs placebo, Outcome 2 DBP.

Comparison 1 Coenzyme Q10 vs placebo, Outcome 3 Heart rate.
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Analysis 1.3

Comparison 1 Coenzyme Q10 vs placebo, Outcome 3 Heart rate.

Summary of findings for the main comparison. Coenzyme Q10 versus placebo in patients with essential arterial hypertension

Patient population: patients with essential arterial hypertension (SBP > 140 mmHg or DBP > 90 mmHg)

Settings: primary care in Japan, Italy and India

Intervention: coenzyme Q10

Comparison: placebo

Outcomes

Relative effect (95% CI)

Number of participants (studies)

Quality of evidence (GRADE)

Comments

Systolic blood pressure (SBP)

‐10.72 [‐13.77, ‐7.67]

96 (3)

Low

Diastolic blood pressure (DBP)

‐6.64 [‐8.10, ‐5.17]

96 (3)

Low

Change in heart rate (HR)

‐12.00 [‐15.19, ‐8.81]

58 (1)

Low

Number of withdrawals due to adverse effects compared to placebo

unknown, reason for withdrawals not reported in Singh 1999

Figuras y tablas -
Summary of findings for the main comparison. Coenzyme Q10 versus placebo in patients with essential arterial hypertension
Comparison 1. Coenzyme Q10 vs placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 SBP Show forest plot

3

96

Mean Difference (Fixed, 95% CI)

‐10.72 [‐13.77, ‐7.67]

2 DBP Show forest plot

3

96

Mean Difference (Fixed, 95% CI)

‐6.64 [‐8.10, ‐5.17]

3 Heart rate Show forest plot

1

58

Mean Difference (Fixed, 95% CI)

‐12.0 [‐15.19, ‐8.81]

Figuras y tablas -
Comparison 1. Coenzyme Q10 vs placebo