Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery
Appendices
Appendix 1. CENTRAL
#1 MeSH descriptor: [Breast Neoplasms] explode all trees
#2 breast near cancer*
#3 breast near neoplasm*
#4 breast near carcinom*
#5 breast near tumour*
#6 breast near tumor*
#7 breast near malignan*
#8 #1 or #2 or #3 or #4 or #5 or #6 or #7
#9 MeSH descriptor: [Anesthesia, Conduction] explode all trees
#10 MeSH descriptor: [Anesthesia, Local] explode all trees
#11 regional and anesthesia
#12 regional and anaesthesia
#13 regional and analgesia
#14 local and anesthesia
#15 local and anaesthesia
#16 local and analgesia
#17 paravertebral and anesthesia
#18 paravertebral and anaesthesia
#19 paravertebral and analgesia
#20 conduction and anesthesia
#21 conduction and anaesthesia
#22 MeSH descriptor: [Nerve Block] explode all trees
#23 paravertebral and block
#24 nerve block
#25 #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or
#23 or #24
#26 #8 and #25
Appendix 2. MEDLINE
| 1 | randomized controlled trial.pt. |
| 2 | controlled clinical trial.pt. |
| 3 | randomized.ab. |
| 4 | placebo.ab. |
| 5 | Clinical Trials as Topic/ |
| 6 | randomly.ab. |
| 7 | trial.ti. |
| 8 | (crossover or cross‐over).tw. |
| 9 | Pragmatic Clinical Trials as Topic/ |
| 10 | pragmatic clinical trial.pt. |
| 11 | or/1‐10 |
| 12 | exp Breast Neoplasms/ |
| 13 | (breast adj6 cancer$).tw. |
| 14 | (breast adj6 neoplasm$).tw. |
| 15 | (breast adj6 carcinoma$).tw. |
| 16 | (breast adj6 tumo?r$).tw. |
| 17 | or/12‐16 |
| 18 | exp Anesthesia, Conduction/ |
| 19 | exp Anesthesia, Local/ |
| 20 | ((regional or local or conduction) adj6 (an?esth* or analges*)).tw. |
| 21 | (paravertebral* adj6 (an?esth* or analges*)).tw. |
| 22 | exp Nerve Block/ |
| 23 | ((paravertebral* or nerve) adj6 block*).tw. |
| 24 | or/18‐23 |
| 25 | 11 and 17 and 24 |
| 26 | animals/ not (humans/ and animals/) |
| 27 | 25 not 26 |
Appendix 3. Embase
| Searches | |
| 1 | Randomized controlled trial/ |
| 2 | Controlled clinical study/ |
| 3 | Random$.ti,ab. |
| 4 | randomization/ |
| 5 | intermethod comparison/ |
| 6 | placebo.ti,ab. |
| 7 | (compare or compared or comparison).ti. |
| 8 | (open adj label).ti,ab. |
| 9 | ((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab. |
| 10 | double blind procedure/ |
| 11 | parallel group$1.ti,ab. |
| 12 | (crossover or cross over).ti,ab. |
| 13 | ((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab. |
| 14 | (assigned or allocated).ti,ab. |
| 15 | (controlled adj7 (study or design or trial)).ti,ab. |
| 16 | (volunteer or volunteers).ti,ab. |
| 17 | trial.ti. |
| 18 | or/1‐17 |
| 19 | exp breast/ |
| 20 | exp breast disease/ |
| 21 | (19 or 20) and exp neoplasm/ |
| 22 | exp breast tumor/ |
| 23 | exp breast cancer/ |
| 24 | exp breast carcinoma/ |
| 25 | (breast$ adj5 (neoplas$ or cancer$ or carcin$ or tumo$ or metasta$ or malig$)).ti,ab. |
| 26 | or/21‐25 |
| 27 | exp regional anesthesia/ |
| 28 | exp local anesthesia/ |
| 29 | ((regional or local) adj6 (an?esth* or analges*)).tw. |
| 30 | (paravertebral* adj6 (an?esth* or analges*)).tw. |
| 31 | (conduction adj6 anesth*).tw. |
| 32 | exp nerve block/ |
| 33 | ((paravertebral* or nerve) adj6 block*).tw. |
| 34 | or/27‐33 |
| 35 | 18 and 26 and 34 |
| 36 | limit 35 to (human and (conference abstracts or embase)) |
Appendix 4. WHO ICTRP
Basic search:
1. Breast cancer AND paravertebral anaesthesia
2. Breast cancer AND regional anaesthesia
3. Breast cancer AND local anaesthesia
4. Breast surgery AND paravertebral anaesthesia
5. Breast surgery AND regional anaesthesia
6. Breast surgery AND local anaesthesia
Advanced search:
1. Condition: Breast cancer or breast neoplasm or breast surgery
Intervention: Paravertebral anaesthesia or regional anaesthesia or local anaesthesia or conduction
anaesthesia or nerve block or paravertebral block
Recruitment status: All
2. Condition: Breast cancer or breast neoplasm or breast surgery
Intervention: paravertebral analgesia or regional analgesia or local analgesia or conduction analgesia
Recruitment status: All
Appendix 5. ClinicalTrials.gov
Basic search:
1. Condition or disease: Breast cancer
Other terms: paravertebral anaesthesia
2. Condition or disease: Breast cancer
Other terms: regional anaesthesia
3. Condition or disease: Breast cancer
Other terms: local anaesthesia
4. Condition or disease: Breast surgery
Other terms: paravertebral anaesthesia
5. Condition or disease: Breast surgery
Other terms: regional anaesthesia
6. Condition or disease: Breast surgery
Other terms: local anaesthesia
Advanced search:
1. Condition or disease: Breast cancer OR breast neoplasm OR breast surgery
Intervention: Paravertebral anaesthesia OR regional anaesthesia OR local anaesthesia OR
conduction anaesthesia
Study type: All studies
Study results: All studies
2. Condition or disease: Breast cancer OR breast neoplasm OR breast surgery
Intervention: Paravertebral analgesia OR regional analgesia OR local analgesia OR conduction
analgesia
Study type: All studies
Study results: All studies
3. Condition or disease: Breast cancer OR breast neoplasm OR breast surgery
Intervention: Nerve block OR paravertebral block
Study type: All studies
Study results: All studies
