Anti‐tumour necrosis factor biological therapies for the treatment of uveitic macular oedema (UMO) for non‐infectious uveitis
Appendices
Appendix 1. CENTRAL search strategy
#1 [mh "Macular Edema"]
#2 [mh "Macula Lutea"]
#3 macula* near/3 oedema
#4 macula* near/3 edema
#5 UMO
#6 maculopath*
#7#1 or #2 or #3 or #4 or #5 or #6
#8 [mh uveitis]
#9 uveiti*
#10 iritis
#11 iridocycliti*
#12 anterior near/2 scleriti*
#13 pars planitis
#14 retinochoroidit* or choroidit*
#15 Bechet* or Vogt or Koyanagi or Harada or Fuch*
#16 [mh retinitis]
#17 retinitis or neuroretinitis
#18 uveoretinitis or uveo retinitis
#19 vitritis or panuveitis or panophthalmiti*
#20 ophthalm* near/2 sympathetic
#21 [mh "arthritis juvenile rheumatoid"]
#22 juvenile near/2 rheumatoid near/2 arthriti*
#23 #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22
#24 [mh ^"Tumor Necrosis Factor‐alpha"]
#25 [mh ^"Antibodies, Monoclonal"]
#26 [mh ^"Antibodies, Monoclonal, Humanized"]
#27 [mh ^Infliximab]
#28 [mh ^Adalimumab]
#29 [mh ^Etanercept]
#30 [mh ^"Certolizumab Pegol"]
#31 remicade* or humira* or enbrel* or golimuab* or simponi* or cimzia*
#32 #24 or #25 or #26 or #27 or #28 or #29 or #30 or #31
#33 #7 and #23 and #32
Appendix 2. MEDLINE Ovid search strategy
1. randomized controlled trial.pt.
2. (randomized or randomised).ab,ti.
3. placebo.ab,ti.
4. dt.fs.
5. randomly.ab,ti.
6. trial.ab,ti.
7. (group or groups).ab,ti.
8. or/1‐7
9. exp animals/
10. exp humans/
11. 9 not (9 and 10)
12. 8 not 11
13. Macular Edema/
14. Macula Lutea/
15. (macula$ adj3 oedema).tw.
16. (macula$ adj3 edema).tw.
17. UMO.tw.
18. maculopath$.tw.
19. or/13‐18
20. exp uveitis/
21. uveiti$.tw.
22. iritis.tw.
23. iridocycliti$.tw.
24. (anterior adj2 scleriti$).tw.
25. pars planitis.tw.
26. (retinochoroidit$ or choroidit$).tw.
27. (Bechet$ or Vogt or Koyanagi or Harada or Fuch$).tw.
28. exp retinitis/
29. (retinitis or neuroretinitis).tw.
30. (uveoretinitis or uveo retinitis).tw.
31. (vitritis or panuveitis or panophthalmiti$).tw.
32. (ophthalm$ adj2 sympathetic).tw.
33. arthritis juvenile rheumatoid/
34. (juvenile adj2 rheumatoid adj2 arthriti$).tw.
35. or/20‐34
36. Tumor Necrosis Factor‐alpha/
37. Antibodies, Monoclonal/
38. Antibodies, Monoclonal, Humanized/
39. Infliximab/
40. Adalimumab/
41. Etanercept/
42. Certolizumab Pegol/
43. (remicade$ or humira$ or enbrel$ or golimuab$ or simponi$ or cimzia$).tw.
44. or/36‐43
45. 19 and 35 and 44
46. 12 and 45
The search filter for trials at the beginning of the MEDLINE strategy is from the published paper by Glanville 2006
Appendix 3. Embase Ovid search strategy
1. exp randomized controlled trial/
2. exp randomization/
3. exp double blind procedure/
4. exp single blind procedure/
5. random$.tw.
6. or/1‐5
7. (animal or animal experiment).sh.
8. human.sh.
9. 7 and 8
10. 7 not 9
11. 6 not 10
12. exp clinical trial/
13. (clin$ adj3 trial$).tw.
14. ((singl$ or doubl$ or trebl$ or tripl$) adj3 (blind$ or mask$)).tw.
15. exp placebo/
16. placebo$.tw.
17. random$.tw.
18. exp experimental design/
19. exp crossover procedure/
20. exp control group/
21. exp latin square design/
22. or/12‐21
23. 22 not 10
24. 23 not 11
25. exp comparative study/
26. exp evaluation/
27. exp prospective study/
28. (control$ or prospectiv$ or volunteer$).tw.
29. or/25‐28
30. 29 not 10
31. 30 not (11 or 23)
32. 11 or 24 or 31
33. exp retina macula edema/
34. eye edema/
35. (macula$ adj3 oedema).tw.
36. (macula$ adj3 edema).tw.
37. UMO.tw.
38. maculopath$.tw.
39. or/33‐38
40. exp eye inflammation/
41. uveiti$.tw.
42. iritis.tw.
43. iridocycliti$.tw.
44. (anterior adj2 scleriti$).tw.
45. pars planitis.tw.
46. (retinochoroidit$ or choroidit$).tw.
47. (Bechet$ or Vogt or Koyanagi or Harada or Fuch$).tw.
48. (retinitis or neuroretinitis).tw.
49. (uveoretinitis or uveo retinitis).tw.
50. (vitritis or panuveitis or panophthalmiti$).tw.
51. (ophthalm$ adj2 sympathetic).tw.
52. arthritis juvenile rheumatoid/
53. (juvenile adj2 rheumatoid adj2 arthriti$).tw.
54. or/40‐53
55. exp tumor necrosis factor alpha/
56. antibodies, monoclonal, humanized/
57. monoclonal antibody/
58. Infliximab/
59. Adalimumab/
60. Etanercept/
61. Certolizumab Pegol/
62. (remicade$ or humira$ or enbrel$ or golimuab$ or simponi$ or cimzia$).tw.
63. or/55‐62
64. 39 and 54 and 63
65. 32 and 64
Appendix 4. Web of Science CPCI search strategy
#10 #9 AND #8 AND #3
#9 TS=(Infliximab OR Adalimumab OR Etanercept OR Certolizumab NEAR/1 Pegol OR remicade* OR humira* OR enbrel* OR golimuab* OR simponi* OR cimzia*)
#8 #4 OR #5 OR #6 OR #7
#7 TS=(vitritis OR panuveitis OR panophthalmiti* OR ophthalm* NEAR/2 sympathetic OR juvenile NEAR/2 rheumatoid NEAR/2 arthriti*)
#6 TS=(retinochoroidit* OR choroidit* OR Bechet* OR Vogt OR Koyanagi OR Harada OR Fuch* OR retinitis OR neuroretinitis OR uveoretinitis OR uveo NEAR/1 retinitis)
#5 TS=(pars NEAR/1 planitis OR anterior NEAR/2 scleriti*)
#4 TS=(uveiti* OR iritis OR iridocycliti*)
#3 #1 OR #2
#2 TS=(UMO OR maculopath*)
#1 TS=(macula* NEAR/3 oedema OR macula* NEAR/3 edema OR macula* NEAR/3 lutea)
Appendix 5. OpenGrey search strategy
(macular oedema OR uveitis) AND (infliximab OR adalimumab OR etanercept OR golimumab OR certolizumab)
Appendix 6. ISRCTN search strategy
"( Condition: macular oedema OR uveitis AND Interventions: infliximab OR adalimumab OR etanercept OR golimumab OR certolizumab )"
Appendix 7. ClinicalTrials.gov search strategy
macula edema OR uveitis | (infliximab OR adalimumab OR etanercept OR golimumab OR certolizumab)
Appendix 8. ICTRP search strategy
macular oedema OR uveitis = CONDITION AND infliximab OR adalimumab OR etanercept OR golimumab OR certolizumab = INTERVENTION
Appendix 9. Data on study characteristics
| Mandatory items | Optional items | |
| Methods | ||
| Study design | · Parallel group RCTi.e. people randomised to treatment · Within‐person RCTi.e. eyes randomised to treatment · Cluster RCTi.e. communities randomised to treatment · Cross‐over RCT · Other, specify | Exclusions after randomisation Losses to follow up Number randomised/analysed How were missing data handled? e.g., available case analysis, imputation methods Reported power calculation (Y/N), if yes, sample size and power Unusual study design/issues |
| Eyes or Unit of randomisation/ unit of analysis | · One eye included in study, specify how eye selected · Two eyes included in study, both eyes received same treatment, briefly specify how analysed (best/worst/average/both and adjusted for within person correlation/both and not adjusted for within person correlation) and specify if mixture one eye and two eye · Two eyes included in study, eyes received different treatments,specify if correct pair‐matched analysis done | |
| Participants | ||
| Country | Setting Ethnic group Equivalence of baseline characteristics (Y/N) | |
| Total number of participants | This information should be collected for total study population recruited into the study. If these data are only reported for the people who were followed up only, please indicate. | |
| Number (%) of men and women | ||
| Average age and age range | ||
| Inclusion criteria | ||
| Exclusion criteria | ||
| Interventions | ||
| Intervention (n= ) Comparator (n= ) See MECIR 65 and 70 | · Number of people randomised to this group · Drug (or intervention) name · Dose · Frequency · Route of administration | |
| Outcomes | ||
| Primary and secondary outcomes as defined in study reports See MECIR R70 | List outcomes Adverse events reported (Y/N) Length of follow up and intervals at which outcomes assessed | Planned/actual length of follow up |
| Notes | ||
| Date conducted | Specify dates of recruitment of participants mm/yr to mm/yr | Full study name: (if applicable) Reported subgroup analyses (Y/N) Were trial investigators contacted? |
| Sources of funding | ||
| Declaration of interest See MECIR 69 | ||
