Appendix 1. MEDLINE Search Strategy

Database: Ovid MEDLINE(R) 1946 to Present with Daily Update
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1 renin/ai
2 (aliskiren or ciprokiren or ditekiren or enalkiren or remikiren or rasilez or tekturna or terlakiren or zankiren).mp.
3 ((RAS or renin) adj2 inhibit$).tw.
4 or/1‐3
5 exp Angiotensin‐Converting Enzyme Inhibitors/
6 ((angiotensin$ or dipeptidyl$ or kininase ii) adj3 (convert$ or enzyme or inhibit$ or recept$ or block$)).tw
7 (ace adj2 inhibit$).tw.
8 acei.tw.
9 (alacepril or altiopril or ancovenin or benazepril or captopril or ceranapril or ceronapril or cilazapril or deacetylalacepril or delapril or derapril or enalapril or enalaprilat or epicaptopril or fasidotril or fosinopril or foroxymithine or gemopatrilat or idapril or imidapril or indolapril or libenzapril or lisinopril or moexipril or moveltipril or omapatrilat or pentopril$ or perindopril$ or pivopril or quinapril$ or ramipril$ or rentiapril or saralasin or s nitrosocaptopril or spirapril$ or temocapril$ or teprotide or trandolapril$ or utibapril$ or zabicipril$ or zofenopril$ or Aceon or Accupril or Altace or Capoten or Lotensin or Mavik or Monopril or Prinivil or Univas or Vasotec or Zestril).tw.
10 or/5‐9
11 exp angiotensin receptor antagonists/
12 (angiotensin adj3 (receptor antagon$ or receptor block$)).tw.
13 (arb or arbs).tw.
14 (abitesartan or azilsartan or candesartan or elisartan or embusartan or eprosartan or forasartan or irbesartan or KT3‐671 or losartan or milfasartan or olmesartan or saprisartan or tasosartan or telmisartan or valsartan or zolasartan).tw.
15 or/11‐14
16 hypertension/
17 (antihypertens$ or hypertens$).tw.
18 ((elevat$ or high$ rais$) adj2 (blood pressure or bp)).tw.
19 or/16‐18
20 randomized controlled trial.pt.
21 controlled clinical trial.pt.
22 randomized.ab.
23 placebo.ab.
24 drug therapy.fs.
25 randomly.ab.
26 trial.ab.
27 groups.ab.
28 or/20‐27
29 animals/ not (humans/ and animals/)
30 Pregnancy/ or Hypertension, Pregnancy‐Induced/ or Pregnancy Complications, Cardiovascular/ or exp Ocular Hypertension/ (885949)
31 (pregnancy‐induced or ocular hypertens$ or preeclampsia or pre‐eclampsia).ti.
32 28 not (29 or 30 or 31)
33 4 and (10 or 15) and 19 and 32