Uso de transfusiones plaquetarias antes de las punciones lumbares o la anestesia epidural para la prevención de las complicaciones en los pacientes con trombocitopenia
Información
- DOI:
- https://doi.org/10.1002/14651858.CD011980.pub3Copiar DOI
- Base de datos:
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- Cochrane Database of Systematic Reviews
- Versión publicada:
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- 30 abril 2018see what's new
- Tipo:
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- Intervention
- Etapa:
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- Review
- Grupo Editorial Cochrane:
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Grupo Cochrane de Hematología
- Copyright:
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- Copyright © 2018 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Cifras del artículo
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Autores
Contributions of authors
Lise Estcourt (LE): protocol and review development, searching, selection of studies, eligibility and quality assessment, data extraction and analysis, and content expert.
Reem Malouf (RM): review development, searching, selection of studies, eligibility and quality assessment, data extraction and analysis.
Sally Hopewell (SH): protocol and review development and methodological expert.
Carolyn Doree (CD): protocol and review development, searching, and selection of studies.
Joost Van Veen (JVV): review development and content expert.
Sources of support
Internal sources
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NHS Blood and Transplant, Research and Development, UK.
To fund the work of the Systematic Review Initiative (SRI)
External sources
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Cochrane Haematological Malignancies Group, Department for Internal Medicine, Germany.
For editorial support
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National Institute for Health Research (NIHR) Cochrane Programme Grant, UK.
To provide funding for systematic review authors and methodological support from the Centre for Statistics in Medicine, Oxford
Declarations of interest
Lise Estcourt (LE): partly funded by the National Institute of Health Research (NIHR) Cochrane Programme Grant ‐ Safe and Appropriate Use of Blood Components.
Reem Malouf (RM): partly funded by the NIHR Cochrane Programme Grant ‐ Safe and Appropriate Use of Blood Components.
Sally Hopewell (SH): partly funded by the NIHR Cochrane Programme Grant ‐ Safe and Appropriate Use of Blood Components.
Carolyn Doree (CD): none known.
Joost Van Veen (JVV): none known.
Acknowledgements
We thank the editorial base of the Cochrane Haematological Malignancies Review Group.
We thank the National Institute of Health Research (NIHR). This review is part of a series of reviews that have been funded by the NIHR Cochrane Programme Grant ‐ Safe and Appropriate Use of Blood Components. This research is also supported by the NIHR Oxford Biomedical Research Centre Programme. The views and opinions expressed in this review are those of the authors and do not necessarily reflect those of the Systematic Reviews Programme, NIHR, National Health Service (NHS), or the Department of Health.
We thank Callum Ingram, Simon Stanworth and Marialena Trivella, who were authors on the original review (Estcourt 2016).
Version history
| Published | Title | Stage | Authors | Version |
| 2018 Apr 30 | Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in people with thrombocytopenia | Review | Lise J Estcourt, Reem Malouf, Sally Hopewell, Carolyn Doree, Joost Van Veen | |
| 2016 May 24 | Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in people with thrombocytopenia | Review | Lise J Estcourt, Callum Ingram, Carolyn Doree, Marialena Trivella, Simon J Stanworth | |
| 2015 Dec 02 | Use of platelet transfusions prior to lumbar punctures or epidural anaesthesia for the prevention of complications in people with thrombocytopenia | Protocol | Lise J Estcourt, Callum Ingram, Carolyn Doree, Sally Hopewell, Marialena Trivella, Simon J Stanworth | |
Differences between protocol and review
There are several differences between the protocol, Estcourt 2015, and this update of the review.
Because we found no eligible randomised controlled trials for inclusion in the previous version of the review (Estcourt 2016), we felt there was a particular need to expand the review scope and examine other study types to aid in answering the review question. We amended the review Methods to accommodate the inclusion of non‐randomised studies in order to reflect these changes.
We made the changes in the following parts of the review.
Search strategy
In this update we did not apply any language restrictions.
Types of studies
We initially included only randomised controlled trials. However, as we did not find any such trials to include in this review update, we thought it would be appropriate to broaden our inclusion criteria and consider studies of other designs. We planned to include:
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longitudinal observational studies using appropriate concurrent comparator; this includes both prospective and retrospective cohort studies;
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non‐randomised controlled trials;
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controlled before‐after studies.
Data extraction and management
We extracted the following further information from studies of other designs.
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Study design
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Selection of the study sample
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Method used to allocate the intervention(s)
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A list of confounding factors reported in the paper
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Other co‐intervention status
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Full description on method of analysing data in the study
Assessment of risk of bias in included studies
We added the application of the ROBINS‐I tool to evaluate the risk of bias for included non‐randomised studies.
Measures of treatment effect
We added details on the treatment effect measures for included non‐randomised studies.
Data synthesis
We added details on the method we followed to analyse data extracted from included non‐randomised studies.
We were unable perform the following due to lack of data.
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Report on all of the primary or secondary outcomes specified in the protocol
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Combine data in a meta‐analysis
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Subgroup analysis
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'Summary of findings' table with data
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Funnel plot to assess for publication bias
Notes
Definitions of technical terms
Disseminated intravascular coagulation: a rare, life‐threatening condition that prevents blood from clotting normally. The blood clots reduce blood flow and can block blood from reaching the body's organs. This increased clotting can use up the platelets and clotting factors in the blood, meaning that fewer platelets and clotting factors are available, which can lead to excessive bleeding.
Haematological malignancies: blood cancers and related diseases that primarily affect the bone marrow or blood cells. The bone marrow is the soft inner part of bones where blood is made.
The three main types of blood cells are:
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red blood cells, which carry oxygen from the lungs to every part of the body;
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white blood cells, which help the body fight infection;
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platelets, which help control bleeding.
Neonatal alloimmune thrombocytopenia: a condition characterised by the destruction of platelets in the foetus or newborn by antibodies produced by the mother. The foetus has proteins on the surface of the platelet that it has inherited from its father but that are not present in the mother. The mother sees these proteins as 'foreign' and may respond by producing antibodies against these intruders. Antibodies are an important part of the body's immune system. The antibodies produced by the mother may cross the placenta, enter the baby's bloodstream, and destroy the unborn baby's platelets.
