Appendix 1. CENTRAL search strategy

#1 MeSH descriptor: [Lung Neoplasms] explode all trees

#2 lung neoplasm*

#3 lung cancer

#4 sclc

#5 nsclc

#6 (lung* or pulm*):ti,ab near/3 (tumor* ot tumour* or cancer* or neoplas* or carcinoma* or adenocarcinoma* or squamous or oat cell or smal cell):ti,ab

#7 #1 or #2 or #3 or #4 or #5 or #6

#8 MeSH descriptor: [Tobacco Use Disorder] explode all trees

#9 Cigarette smok*

#10 continued cigarette*

#11 continued smoking

#12 current smok*

#13 smoking status

#14 still smok*

#15 tobacco dependen*

#16 tobacco addict*

#17 #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16

#18 #7 and #17

#19 MeSH descriptor: [Bupropion] explode all trees

#20 MeSH descriptor: [Tobacco Use Cessation Products] explode all trees

#21 bupropion

#22 vareniclin*

#23 MeSH descriptor: [Smoking Cessation] explode all trees

#24 MeSH descriptor: [Tobacco Use Cessation] explode all trees

#25 MeSH descriptor: [Tobacco Use Cessation Products] explode all trees

#26 smoking cessation

#27 smoking:ti,ab near/5 (quit* or stop* or ceas*):ti,ab

#28 #19 or #20 or #21 or #22 or #23 or #24 or #25 or #26 or #27

#29 #18 and #28

Appendix 2. MEDLINE search strategy

1 Carcinoma, Non‐Small‐Cell Lung[Mesh]

2 Lung Neoplasms[Mesh]

3 Small Cell Lung Carcinoma[Mesh]

4 lung cancer[Title/Abstract]

5 lung tumor*[Title/Abstract]

6 lung tumour*[Title/Abstract]

7 non‐small‐cell lung*[Title/Abstract]

8 NSCLC[Title/Abstract]

9 SCLC[Title/Abstract]

10 small‐cell lung cancer[Title/Abstract]

11 1 OR 2 OR 3 OR 4 OR 5 OR 6 OR 7 OR 8 OR 9 OR 10

12 (lung*[Title/Abstract] OR pulm*[Title/Abstract]) AND (tumor*[Title/Abstract] OR tumour*[Title/Abstract] OR squamous[Title/Abstract] OR oat cell*[Title/Abstract])

13 11 OR 12

14 Tobacco Use Disorder[Mesh]

15 Cigarette smok*[Title/Abstract]

16 continued cigarette*[Title/Abstract]

17 continued smoking[Title/Abstract]

18 current smok*[Title/Abstract]

19 smoking status[Title/Abstract]

20 still smok*[Title/Abstract]

21 tobacco dependen*[Title/Abstract]

22 tobacco addict*[Title/Abstract]

23 14 OR 15 OR 16 OR 17 OR 18 OR 19 OR 20 OR 21 OR 22

24 smok*[Title/Abstract] AND (post diagnos*[Title/Abstract] OR postdiag*[Title/Abstract] OR after diag*[Title/Abstract])

25 23 OR 24

26 13 AND 25

27 acupuncture[MeSH]

28 Anti‐Anxiety Agents[MeSH]

29 Antidepressive Agents[MeSH]

30 Antidepressive Agents, Second‐Generation[MeSH]

31 Azocines[MeSH]

32 Behavior Therapy[MeSH]

33 Benzazepines[MeSh]

34 Bupropion[MeSH]

35 Counseling[MeSH]

36 Directive Counseling[MeSH]

37 Exercise[Mesh]

38 Hypnosis[Mesh]

39 Nicotinic Agonists[MeSH]

40 Nicotinic Antagonists[MeSH]

41 Nortriptyline[MeSH]

42 Patient Education as Topic[MeSH]

43 Quinolizines[MeSH]

44 Quinoxalines[MeSH]

45 Smoking Cessation[MeSH]

46 Tobacco Use Cessation[MeSH]

47 Tobacco Use Cessation Products[MeSH]

48 abstinen*[Title/Abstract]

49 acupuncture[Title/Abstract]

50 antidepressant*[Title/Abstract]

51 anxiolyti*[Title/Abstract]

52 bupropion[Title/Abstract]

53 cessation aid*[Title/Abstract]

54 clonidine[Title/Abstract]

55 counseling[Title/Abstract]

56 cytisine[Title/Abstract]

57 dianicline[Title/Abstract]

58 doxepin*[Title/Abstract]

59 exercise[Title/Abstract]

60 fluoxetin*[Title/Abstract]

61 hypnosis[Title/Abstract]

62 imipramin*[Title/Abstract]

63 lazabemide*[Title/Abstract]

64 lobeline[Title/Abstract]

65 mecamylamine[Title/Abstract]

66 moclobemide[Title/Abstract]

67 nicobrevin*[Title/Abstract]

68 nicotine gum*[Title/Abstract]

69 nicotine inhaler*[Title/Abstract]

70 nicotine nasal spray*[Title/Abstract]

71 nicotine patch*[Title/Abstract]

72 nicotine therap*[Title/Abstract]

73 nicotine vaccin*[Title/Abstract]

74 Nortriptyline[Title/Abstract]

75 NRT[Title/Abstract]

76 nicotine replacement therap*[Title/Abstract]

77 paroxetin*[Title/Abstract]

78 patient education[Title/Abstract]

79 quit smoking[Title/Abstract]

80 quitting smok*[Title/Abstract]

81 rimonabant[Title/Abstract]

82 selegilin*[Title/Abstract]

83 sertralin*[Title/Abstract]

84 silver acetat*[Title/Abstract]

85 smoking cessation[Title/Abstract]

86 stop smoking[Title/Abstract]

87 stopping smoking[Title/Abstract]

88 tobacco cessation[Title/Abstract]

89 tobacco treatment[Title/Abstract]

90 tobacco use[Title/Abstract]

91 tryptophan*[Title/Abstract]

92 vareniclin*[Title/Abstract]

93 venlafaxin*[Title/Abstract]

94 zimeledin*[Title/Abstract]

95 27 OR 28 OR 29 OR 30 OR 31 OR 32 OR 33 OR 34 OR 35 OR 36 OR 37 OR 38 OR 39 OR 40 OR 41 OR 42 OR 43 OR 44 OR 45 OR 46 OR 47 OR 48 OR 49 OR 50 OR 51 OR 52 OR 53 OR 54 OR 55 OR 56 OR 57 OR 58 OR 59 OR 60 OR 61 OR 62 OR 63 OR 64 OR 65 OR 66 OR 67 OR 68 OR 69 OR 70 OR 71 OR 72 OR 73 OR 74 OR 75 OR 76 OR 77 OR 78 OR 79 OR 80 OR 81 OR 82 OR 83 OR 84 OR 85 OR 86 OR 87 OR 88 OR 89 OR 90 OR 91 OR 92 OR 93 OR 94

96 26 AND 95

97 (randomized controlled trial [pt] OR controlled clinical trial [pt] OR randomized [tiab] OR placebo [tiab] OR drug therapy [sh] OR randomly [tiab] OR trial [tiab] OR groups [tiab])

98 animals [mh] NOT humans [mh]

99 97 NOT 98

100 96 AND 99

Appendix 3. EMBASE search strategy

1 exp lung cancer/

2 exp lung tumor/

3 lung neoplasm*.mp.

4 lung cancer.mp.

5 SCLC.ti,ab.

6 NSCLC.ti,ab.

7 ((lung* or pulmon*) adj5 (tumor* or tumour* or cancer or neoplas* or carcinoma* or adenocarcinoma or squamous or oat cell or small cell)).ti,ab.

8 1 or 2 or 3 or 4 or 5 or 6 or 7

9 exp smoking cessation/

10 smoking cessation.ti,ab.

11 (smoking adj5 (quit* or stop* or ceas*)).ti,ab.

12 9 or 10 or 11

13 8 and 12

14 random:.tw. or clinical trial:.mp. or exp health care quality/

15 13 and 14