Appendix 1. CENTRAL

 #1  MeSH descriptor: [Uterine Cervical Neoplasms] this term only
#2  (cervi* near/5 (cancer* or neoplas* or carcinoma* or tumor* or tumour* or malignan*))
#3  #1 or #2
#4  Any MeSH descriptor with qualifier(s): [Radiotherapy ‐ RT]
#5  MeSH descriptor: [Radiotherapy] explode all trees
#6  MeSH descriptor: [Chemoradiotherapy] explode all trees
#7  (radiotherap* or radiat* or irradiat* or chemoradi* or radiochemo*)
#8  #4 or #5 or #6 or 7
#9  Any MeSH descriptor with qualifier(s): [Drug therapy ‐ DT]
#10 MeSH descriptor: [Antineoplastic Agents] explode all trees
#11 MeSH descriptor: [Antineoplastic Combined Chemotherapy Protocols] this term only
#12 MeSH descriptor: [Chemotherapy, Adjuvant] explode all trees
#13 chemo*
#14 #9 or #10 or #11 or #12 or #13
#15 #3 and #8 and #14

Appendix 2. MEDLINE search strategy

1.       Uterine Cervical Neoplasms/
2.       (cervi* adj5 (cancer* or neoplas* or carcinoma* or tumor* or tumour* or malignan*)).mp.
3.       1 or 2
4.       radiotherapy.fs.
5.       exp Radiotherapy/
6.       exp Chemoradiotherapy/
7.       (radiotherap* or radiat* or irradiat* or chemoradi* or radiochemo*).mp.
8.       4 or 5 or 6 or 7
9.       drug therapy.fs.
10.    exp Antineoplastic Agents/
11.    Antineoplastic Combined Chemotherapy Protocols/
12.    Chemotherapy, Adjuvant/
13.    chemo*.mp.
14.    9 or 10 or 11 or 12 or 13
15.    3 and 8 and 14
16.    randomized controlled trial.pt.
17.    controlled clinical trial.pt.
18.    randomized.ab.
19.    placebo.ab.
20.    clinical trials as topic.sh.
21.    randomly.ab.
22.    trial.ti.
23.    16 or 17 or 18 or 19 or 20 or 21 or 22
24.    15 and 23
25.    exp animals/ not humans.sh.
26.    24 not 25

key: mp=title, abstract, original title, name of substance word, subject heading word, protocol supplementary concept, rare disease supplementary concept, unique identifier, pt=publication type, ab=abstract, ti=title, sh=subject heading, fs=floating subheading, exp=exploded term

Appendix 3. EMBASE

1.     exp uterine cervix tumor/
2.     (cervi* adj5 (cancer* or neoplas* or carcinoma* or tumor* or tumour* or malignan*)).mp.
3.     1 or 2
4.     rt.fs.
5.     exp radiotherapy/
6.     exp chemoradiotherapy/
7.     (radiotherap* or radiat* or irradiat* or chemoradi* or radiochemo*).mp.
8.     4 or 5 or 6 or 7
9.     dt.fs.
10.  exp antineoplastic agent/
11.  exp chemotherapy/
12.  chemo*.mp.
13.  9 or 10 or 11 or 12
14.  3 and 8 and 13
15.  crossover procedure/
16.  double‐blind procedure/
17.  randomized controlled trial/
18.  single‐blind procedure/
19.  random*.mp.
20.  factorial*.mp.
21.  (crossover* or cross over* or cross‐over*).mp.
22.  placebo*.mp.
23.  (double* adj blind*).mp.
24.  (singl* adj blind*).mp.
25.  assign*.mp.
26.  allocat*.mp.
27.  volunteer*.mp.
28.  15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27
29.  14 and 28
30.  (exp animal/ or nonhuman/ or exp animal experiment/) not human/
31.  29 not 30

 key: [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword]

Appendix 4. The Cochrane Collaboration tool for assessing risk of bias in included studies