Не‐хирургические вмешательства в лечении тяжелых менструальных кровотечений (меноррагии) у женщин с нарушениями свертываемости крови
Appendices
Appendix 1. Embase search strategy
Search in Embase 03 May 2013.
#1. 'menorrhagia'/exp
#2. heavy NEAR/2 'menstrual bleeding'
#3. heavy NEAR/2 menstru* AND bleed*:ab,ti
#4. menorrhagia:ab,ti
#5. 'menstrual blood loss' NEAR/2 heavy
#6. 'menorrhagia'/exp OR heavy NEAR/2 'menstrual bleeding' OR (heavy NEAR/2 menstru* AND bleed*:ab,ti) OR menorrhagia:ab,ti OR 'menstrual blood loss' NEAR/2 heavy
#7. 'bleeding disorder'/exp OR 'blood clotting disorder'/exp
#8. 'bleeding disorder':ab,ti
#9. 'blood clotting factor deficiency'/exp
#10. 'blood protein disorder'/exp
#11. 'blood clotting factor'/exp AND deficiency:ab,ti
#12. 'bleeding disorder'/exp OR 'blood clotting disorder'/exp OR 'bleeding disorder':ab,ti OR 'blood clotting factor deficiency'/exp OR 'blood protein disorder'/exp OR ('blood clotting factor'/exp AND deficiency:ab,ti)
#13. 'non surgical':ab,ti
#14. 'tranexamic acid'/exp OR 'mefenamic acid'/exp OR 'oral contraceptive agent'/exp OR 'combined oral contraceptives':ab,ti OR 'progesterone'/exp OR 'danazol'/exp OR 'etamsylate'/exp OR 'desmopressin'/exp OR 'factor replacement therapy':ab,ti
#15. 'non surgical':ab,ti OR 'tranexamic acid'/exp OR 'mefenamic acid'/exp OR 'oral contraceptive agent'/exp OR 'combined oral contraceptives':ab,ti OR 'progesterone'/exp OR 'danazol'/exp OR 'etamsylate'/exp OR 'desmopressin'/exp OR 'factor replacement therapy':ab,ti
#16. 'menorrhagia'/exp OR heavy NEAR/2 'menstrual bleeding' OR (heavy NEAR/2 menstru* AND bleed*:ab,ti) OR menorrhagia:ab,ti OR 'menstrual blood loss' NEAR/2 heavy AND ('bleeding disorder'/exp OR 'blood clotting disorder'/exp OR 'bleeding disorder':ab,ti OR 'blood clotting factor deficiency'/exp OR 'blood protein disorder'/exp OR ('blood clotting factor'/exp ANDdeficiency:ab,ti)) AND ('non surgical':ab,ti OR 'tranexamic acid'/exp OR 'mefenamic acid'/exp OR 'oral contraceptive agent'/exp OR 'combined oral contraceptives':ab,ti OR 'progesterone'/expOR 'danazol'/exp OR 'etamsylate'/exp OR 'desmopressin'/exp OR 'factor replacement therapy':ab,ti)
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Appendix 2. LILACS search strategy
Search in LILACS on 24 February 2013
# 1 Menorrhagia ab,ti
# 2 Menorrhagia and bleeding disorders ab,ti
Appendix 3. WHO International Clinical Trials Registry Platform's search portal
Search in WHo International Clinical Trials Registry 24 February 2013
# Menorrhaga ti,AND bleeding disorders
Study flow diagram.
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Forest plot of comparison: 1 DDAVP Vs Placebo, outcome: 1.1 Adverse effects.
Forest plot of comparison: 2 Desmopressin versus Tranaxemic Acid, outcome: 2.1 Adverse effects.
Comparison 1 Desmopressin versus placebo, Outcome 1 Adverse effects.
Comparison 2 Desmopressin versus tranexamic acid, Outcome 1 Adverse effects.
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Adverse effects Show forest plot | 2 | 88 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.04 [0.73, 1.49] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Adverse effects Show forest plot | 1 | Risk Ratio (M‐H, Fixed, 95% CI) | Totals not selected | |
