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Mycophenolate mofetil versus methotrexate for prevention of acute graft‐versus‐host disease in patients receiving allogeneic hematopoietic stem cell transplantation

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Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

The primary objective of this review is to assess the effect of mycophenolate mofetil versus methotrexate for the prevention of acute GVHD in patients undergoing allo‐HCT.

Our secondary objectives are to evaluate the effect of methotrexate versus mycophenolate mofetil in terms of the prevention of chronic GVHD, relapse rate, treatment‐related harms, and non‐relapse mortality.