Dosis única oral de ibuprofeno más codeína para el dolor posoperatorio agudo en adultos
Información
- DOI:
- https://doi.org/10.1002/14651858.CD010107.pub2Copiar DOI
- Base de datos:
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- Cochrane Database of Systematic Reviews
- Versión publicada:
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- 28 marzo 2013see what's new
- Tipo:
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- Intervention
- Etapa:
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- Review
- Grupo Editorial Cochrane:
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Grupo Cochrane de Dolor y cuidados paliativos
- Copyright:
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- Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Cifras del artículo
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Autores
Contributions of authors
All authors contributed to writing the protocol. SK and SD carried out searches, assessed studies for inclusion, and extracted data. RAM acted as arbitrator. All authors were involved in writing the review. RAM will be responsible for updating the review.
Sources of support
Internal sources
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Oxford Pain Relief Trust, UK.
External sources
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No sources of support supplied
Declarations of interest
RAM and SD have received research support from charities, government and industry sources at various times. RAM has consulted for various pharmaceutical companies and has received lecture fees from pharmaceutical companies related to analgesics and other healthcare interventions. SK has no interests to declare.
Acknowledgements
This review received infrastructure support from the Oxford Pain Relief Trust.
Version history
| Published | Title | Stage | Authors | Version |
| 2015 Feb 05 | Single dose oral ibuprofen plus codeine for acute postoperative pain in adults | Review | Sheena Derry, Samuel M Karlin, R Andrew Moore | |
| 2013 Mar 28 | Single dose oral ibuprofen plus codeine for acute postoperative pain in adults | Review | Sheena Derry, Samuel M Karlin, R Andrew Moore | |
| 2012 Sep 12 | Single dose oral ibuprofen plus codeine for acute postoperative pain in adults | Protocol | Sheena Derry, Samuel M Karlin, R Andrew Moore | |
Differences between protocol and review
Additional information relating to the criteria used to assess risk of bias have been added since the protocol was published.
Keywords
MeSH
Medical Subject Headings (MeSH) Keywords
Medical Subject Headings Check Words
Adult; Humans;
PICO
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Forest plot of comparison: ibuprofen 400 mg + high dose codeine versus placebo, outcome: 2.1 Participants with ≥ 50% pain relief.
Studies comparing ibuprofen plus codeine with placebo, with the outcome of at least 50% maximum pain relief over 4‐6 hours. Colour code: white ‐ ibuprofen 200 mg + codeine 15 mg; yellow ‐ ibuprofen 200 mg + codeine 30 mg; light pink ‐ ibuprofen 400 mg + codeine 25.6 mg; medium pink ‐ ibuprofen 400 mg + codeine 30 mg; red ‐ ibuprofen 400 mg + codeine 60 mg; blue ‐ ibuprofen 800 mg + codeine 60 mg.
Studies comparing ibuprofen plus codeine with same dose of ibuprofen, with the outcome of at least 50% maximum pain relief over 4‐6 hours. Colour code: darker yellow ‐ ibuprofen 200 mg + codeine 20 mg versus ibuprofen 200 mg; lighter yellow ‐ ibuprofen 400 mg + codeine 60 mg versus ibuprofen 400 mg.
Forest plot of comparison: ibuprofen + codeine (all doses) versus same dose of ibuprofen alone, outcome: 3.1 Participants with ≥ 50% pain relief.
Comparison 1 Ibuprofen 400 mg + high dose codeine versus placebo, Outcome 1 Participants with ≥ 50% pain relief.
Comparison 1 Ibuprofen 400 mg + high dose codeine versus placebo, Outcome 2 Participants with any adverse event.
Comparison 2 Ibuprofen + codeine (all doses) versus same dose of ibuprofen alone, Outcome 1 Participants with ≥ 50% pain relief.
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Participants with ≥ 50% pain relief Show forest plot | 4 | 443 | Risk Ratio (M‐H, Fixed, 95% CI) | 4.09 [2.82, 5.93] |
| 2 Participants with any adverse event Show forest plot | 4 | 443 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.18 [0.84, 1.66] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Participants with ≥ 50% pain relief Show forest plot | 3 | 204 | Risk Ratio (M‐H, Fixed, 95% CI) | 1.26 [1.01, 1.57] |
