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Cochrane Database of Systematic Reviews

Amitriptilina versus placebo para el trastorno depresivo mayor

Información

DOI:
https://doi.org/10.1002/14651858.CD009138.pub2Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 12 diciembre 2012see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:

  1. Grupo Cochrane de Trastornos mentales comunes

Copyright:
  1. Copyright © 2012 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Autores

  • Claudia Leucht

    Correspondencia a: Klinik und Poliklinik für Psychiatrie und Psychotherapie, Technische Universität München Klinikum rechts der Isar, München, Germany

    [email protected]

    [email protected]

  • Maximilian Huhn

    Klinik und Poliklinik für Psychiatrie und Psychotherapie, Technische Universität München Klinikum rechts der Isar, München, Germany

  • Stefan Leucht

    Klinik und Poliklinik für Psychiatrie und Psychotherapie, Technische Universität München Klinikum rechts der Isar, München, Germany

Contributions of authors

Claudia Leucht: protocol development, search, study selection, data extraction, statistical analysis, interpretation of results, writing the review.

Stefan Leucht: protocol development, search, study selection, statistical analysis, interpretation of results, writing the review.

Maximilian Huhn: protocol development, search, study selection, data extraction, writing the review.

Sources of support

Internal sources

  • Klinikum rechts der Isar der Technischen Universität München, Germany.

    The authors are employees of this hospital

External sources

  • German Ministry of Education and Research, Bundesministerium für Bildung und Forschung (BMBF) Grant number: 01KG1029, Germany.

    Grant support

Declarations of interest

Stefan Leucht: has received honoraria for consulting/advisory boards from Alkermes, BristolMyersSquibb, EliLilly, Janssen, Johnson&Johnson, Medavante, Roche, lecture honoraria from AstraZeneca, BristolMyersSquibb, EliLilly, EssexPharma, Janssen, Johnson&Johnson, Lundbeck Institute, Pfizer and SanofiAventis, and EliLilly has provided medication for a trial with SL as the primary investigator.

Claudia Leucht: is Stefan Leucht's wife. Therefore, his conflicts of interest in part also apply to her. She has no other conflicts of interest.

Maximilian Huhn: none to declare.

Acknowledgements

We thank the editorial team of CCDAN for its generous support. We thank Magdolna Tardy for her help in the final stages of this review. We also thank Drs. Claghorn, Kahn, Kupfer, Bakish, Klieser, Follingstad, Stassen and Höschl and the pharmaceutical companies Organon, Merck Sonoro, Hexal and Bayer for replying to our letters. Organon provided us with additional data from already published studies as well as with data from two unpublished trials.

Version history

Published

Title

Stage

Authors

Version

2012 Dec 12

Amitriptyline versus placebo for major depressive disorder

Review

Claudia Leucht, Maximilian Huhn, Stefan Leucht

https://doi.org/10.1002/14651858.CD009138.pub2

2011 May 11

Amitriptyline versus placebo for major depressive disorder

Protocol

Claudia Leucht, Maximilian Huhn, Stefan Leucht

https://doi.org/10.1002/14651858.CD009138

Differences between protocol and review

In the protocol we had planned to use the mean standard deviation of the other studies in this review when the standard deviation of a study was missing. As we felt that the number of studies indicating a standard deviation was too small to provide a representative mean, we instead used the standard deviations from the MANGA project (Cipriani 2009) to the update of which this review will contribute.