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Tratamiento con corticosteroides transplacentarios versus corticosteroides fetales directos para acelerar la maduración pulmonar fetal cuando hay riesgo de parto prematuro

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Referencias

References to studies excluded from this review

Babovic 2015 {published data only}

Babovic I, Radojicic Z, Plesinac S, Kastratovic Kotlica B, Sparic R. Direct intramuscular fetal or maternal antenatal corticosteroid therapy: short‐time effects on fetal behavior and oxygenation: a comparative study. Journal of Maternal‐fetal & Neonatal Medicine2016; Vol. 29, issue 19:3213‐7. CENTRAL

References to studies awaiting assessment

Ljubic 2000 {published data only}

Ljubic A, Cvetkovic M, Sulovic V, Dukanac J, Antonovic O, Petkovic S. RDS prevention: direct fetal versus transplacental corticosteroid therapy [abstract]. XVI FIGO World Congress of Obstetrics & Gynecology (Book 2); 2000 Sept 3‐8; Washington DC, USA. 2000:156. CENTRAL

AIHW 2015

Australian Institute of Health and Welfare (AIHW). Australia's Mothers and Babies 2013—in brief. Perinatal statistics series no. 31. Cat. no. PER 72. Canberra: AIHW, 2015.

Antenatal Corticosteroid Guidelines Panel 2015

Antenatal Corticosteroid Clinical Practice Guidelines Panel. Antenatal Corticosteroids Given to Women Prior to Birth to Improve Fetal, Infant, Child and Adult Health: Clinical Practice Guidelines 2015. The University of Auckland, Auckland. New Zealand.: Liggins Institute, 2015.

Babovic 2009

Babovic I, Plesinak S, Opalik J, Devrnjaa V, Pavlovic I, Radojicic Z, et al. Intramuscular fetal corticosteroid therapy: short term effects on the fetus. Fetal Diagnosis and Therapy 2009;25(1):98‐101.

Ballard 1995

Ballard PL, Ballard RA. Scientific basis and therapeutic regimens for use of antenatal glucocorticoids. American Journal of Obstetrics and Gynecology 1995;173(1):254‐62.

Beck 2010

Beck S, Wojdyla D, Say L, Betran AP, Merialdi M, Requejo JH, et al. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bulletin of the World Health Organization 2010;88(1):31‐8.

Benediktsson 1993

Benediktsson R, Lindsay RS, Noble J, Secki JR, Edwards CR. Glucocorticoid exposure in utero: new model for adult hypertension. Lancet 1993;341(8841):339‐41.

Brownfoot 2013

Brownfoot FC, Gagliardi DI, Bain E, Middleton P, Crowther CA. Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database of Systematic Reviews 2013, Issue 8. [DOI: 10.1002/14651858.CD006764.pub3]

Crowther 2015

Crowther CA, McKinlay CJD, Middleton P, Harding JE. Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes. Cochrane Database of Systematic Reviews 2015, Issue 7. [DOI: 10.1002/14651858.CD003935.pub4]

Dalziel 2005

Dalziel SR, Lim VK, Lambert A, McCarthy D, Parag V, Rodgers A, et al. Antenatal exposure to betamethasone: psychological functioning and health related quality of life 31 years after inclusion in randomised controlled trials. BMJ 2005;331(7518):665.

Doyle 2001

Doyle LW, Victorian Infant Collaborative Study Group. Outcome at 5 years of age of children 23 to 27 weeks gestation: refining the prognosis. Pediatrics 2001;108(1):134‐41.

Evans 1993

Evans MI, Pryde PG, Reichler A, Bardicef M, Johnson MP. Fetal drug therapy. Western Journal of Medicine 1993;159(3):325‐32.

Fowden 1996

Fowden AL, Szemere J, Hughes RS, Forhead AJ. The effects of cortisol on the growth rate of the sheep fetus during late gestation. Journal of Endocrinology 1996;151(1):97‐105.

Goldenberg 2007

Goldenberg R, Culhane JF, Iams J, Romero R. Epidemiology and causes of preterm birth. Lancet 2007;371(9606):73‐82.

Gordon 2002

Gordon MC, Narula K, O'Shaughnessy R, Barth WH. Complications of third trimester amniocentesis using continuous ultrasound guidance. Obstetrics & Gynecology 2002;99(2):255‐9.

Haram 2003

Haram K, Mortensen JH, Wollen AL. Preterm delivery: an overview. Acta Obstetricia et Gynecologica Scandinavica 2003;82(8):687‐704.

Higgins 2011

Higgins JPT, Green S, editor(s). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane‐handbook.org.

Jackson 2003

Jackson JR, Kleeman S, Doerzbacher M, Lambers DS. The effect of glucocorticosteroid administration on fetal movements and biophysical profile scores in normal pregnancies. Journal of Maternal‐fetal & Neonatal Medicine 2003;13(1):50‐3.

Jobe 1993

Jobe AH, Polk D, Ikegami M, Newnham J, Sly P, Kohen R, et al. Lung responses to ultrasound‐guided fetal treatments with corticosteroids in preterm lambs. Journal of Applied Physiology 1993;75(5):2099‐105.

Jobe 1998

Jobe AH, Newnham J, Willet K, Sly P, Ikegami M. Fetal versus maternal and gestational age effects of repetitive antenatal glucocorticoids. Pediatrics 1998;102(5):1116‐25.

Jobe 2004

Jobe AH, Soll RF. Choice and dose of corticosteroid for antenatal treatments. American Journal of Obstetrics and Gynecology 2004;190(4):878‐81.

Liggins 1972

Liggins GC, Howie RNA. A control trial of antepartum glucocorticoid treatment in prevention of the respiratory distress syndrome in premature infants. Pediatrics 1972;50(4):515‐25.

Ljubic 1999

Ljubic A, Cvetkovic M, Sulovic V, Radunovic N, Antonovic O, Vukolic D, et al. New technique for artificial lung maturation. Direct intramuscular fetal corticosteroid therapy. Clinical and Experimental Obstetrics and Gynecology 1999;26(1):16‐9.

McGoldrick 2016

McGoldrick E, Brown J, Middleton P, McKinlay CJD, Haas DM, Crowther CA. Antenatal corticosteroids for fetal lung maturation: an overview of Cochrane reviews. Cochrane Database of Systematic Reviews 2016, Issue 4. [DOI: 10.1002/14651858.CD012156]

Moss 2003

Moss TJ, Doherty DA, Nitsos I, Harding R, Newnham JP. Pharmacokinetics of betamethasone after maternal or fetal intramuscular administration. American Journal of Obstetrics and Gynecology 2003;189(6):1751‐7.

Newnham 1999

Newnham JP, Evans SF, Godfrey ME, Huang WL, Ikegami M, Jobe A. Maternal, but not fetal, administration of corticosteroids restricts fetal growth. Journal of Maternal‐Fetal Medicine 1999;8(3):81‐7.

NIH 1995

Anonymous. Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH Consensus Development Panel on the Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes. JAMA 1995;273(5):413‐8.

RCOG 2010

Royal College of Obstetricians and Gynaecologists. Amniocentesis and Chorionic Villus Sampling Green‐top Guideline 8. London: RCOG, June 2010.

RevMan 2014 [Computer program]

The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.

Roberts 2017

Roberts D, Brown J, Medley N, Dalziel SR. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database of Systematic Reviews 2017, Issue 3. [DOI: 10.1002/14651858.CD004454.pub3]

Saigal 2007

Saigal S, Doyle LW. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 2007;371(9608):261‐9.

WHO 2015

World Health Organization. WHO Recommendations on Interventions to Improve Preterm Birth Outcomes. Geneva: World Health Organization, 2015.

References to other published versions of this review

Utama 2011a

Utama DP, Crowther CA. Transplacental versus direct fetal corticosteroid treatment for accelerating fetal lung maturation where there is a risk of preterm birth. Cochrane Database of Systematic Reviews 2011, Issue 2. [DOI: 10.1002/14651858.CD008981]

Utama 2011b

Utama DP, Crowther CA. Transplacental versus direct fetal corticosteroid treatment for accelerating fetal lung maturation where there is a risk of preterm birth. Cochrane Database of Systematic Reviews 2011, Issue 9. [DOI: 10.1002/14651858.CD008981.pub2]

Characteristics of studies

Characteristics of excluded studies [ordered by study ID]

Study

Reason for exclusion

Babovic 2015

This was not a randomised controlled trial; quote: "They were divided into two groups". Dr Babovic was contacted by email, and provided additional detail about the study methodology.

Characteristics of studies awaiting assessment [ordered by study ID]

Ljubic 2000

Methods

Unknown

Participants

65 women at risk of preterm birth

Interventions

35 women (group A) received single 4 mg dose of dexamethasone delivered intramuscularly to the fetus under ultrasound guidance, and 30 women (group B) received single 24 mg dose of dexamethasone intramuscularly.

Outcomes

Apgar score, perinatal mortality, RDS, intracranial haemorrhage, maternal morbidity (aggravation of hypertension and diabetes mellitus).

Notes

We have contacted the author about the study's design and particularly the method of treatment allocation. We are awaiting a reply.

RDS: respiratory distress syndrome

Study flow diagram.
Figuras y tablas -
Figure 1

Study flow diagram.