Appendix 1. Search strategy

#1 MeSH descriptor Pharyngitis explode all trees
#2 pharyngit*
#3 MeSH descriptor Nasopharyngitis explode all trees
#4 (Retropharyngeal OR Peritonsillar) NEAR Abscess
#5 nasopharyngit*
#6 MeSH descriptor Tonsillitis explode all trees
#7 tonsillit*
#8 (SORE* or INFLAMM* or INFECT*) NEAR THROAT
#9 Pharyngotonsillitis
#10 (#1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9)
#11 MeSH descriptor Anti‐Bacterial Agents explode all trees
#12 MeSH descriptor Antibiotic Prophylaxis explode all trees
#13 MeSH descriptor Lactams explode all trees
#14 MeSH descriptor Quinolones explode all trees
#15 MeSH descriptor Macrolides explode all trees
#16 antibiot* OR (anti ADJ biot*) OR antimicrobial* OR (anti ADJ microbial*) OR bacteriocid* OR antibacterial* OR (anti ADJ bacterial*)
#17 penicillin* OR amoxicillin OR ampicillin OR clavulanic acid OR amoxiclav OR augmentin OR ticarcillin OR timentin OR flucloxacillin OR fluampicil OR magnapen OR piperacillin OR tazocin
#18 cephalosporin* OR cefaclor OR distaclor OR cefadroxil OR baxan OR cefalexin OR ceporex OR keflex OR cefamandole OR kefadol OR cefazolin OR kefzol OR cefixime OR suprax OR cefotaxime OR claforan OR cefoxitin OR mefoxin OR cefpirome OR cefrom OR cefpodoxime OR orelox OR cefprozil OR cefzil OR cefradine OR velosel OR ceftazidime OR fortum OR kefadim OR ceftriaxone OR rocephin OR cefuroxime OR zinacef OR zinnat OR cefonicid OR aztreonam OR azactam OR imipenem OR cilastatin OR primaxin OR meropenem or meronem or tetracycline* or deteclo or demecleocyclin or ledermycin or doxycycline or vibramycin or minocycline or minocine or oxytetracycline or terramycin
#19 macrolide* OR erythromycin OR erymax OR erythrocin OR erythroped OR azithromycin OR zithromax OR clarithromycin OR klaricid OR telithromycin OR ketek OR trimoxazole OR septrin OR trimethoprim OR monotrim OR trimopan OR metronidazole OR flagyl OR metrolyl
#20 quinolone* OR ciprofloxacin OR ciproxin
#21 (#11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20)
#22 (#10 AND #21)
#23 MeSH descriptor Recurrence explode all trees
#24 recurr* or recrudesc* or relaps* or reappear*
#25 MeSH descriptor Secondary Prevention explode all trees
#26 prophyla* or prevent*
#27 (#23 OR #24 OR #25 OR #26)
#28 (#22 AND #27)